№ files_lp_4_process_3_071647
File format: docx
Character count: 1863
File size: 23 KB
Supplementary scientific material listing the content and analytical context of tables reporting kinetic measurements, correlation analyses, and pharmacokinetic parameters for vemurafenib metabolism in human liver microsomes and genetically modified mouse models.
Type of document:
Supplementary table legends
Research field:
Pharmacology
Research topic:
Metabolism and pharmacokinetics of vemurafenib
Analyzed compound:
Vemurafenib
Metabolite:
OH-vemurafenib
Biological system:
Human liver microsomes (HLM) and transgenic mouse models
Experimental models:
Cyp3aKO/Cyp3a13+/+, huCYP3A4/3A7, huPXR/huCAR/huCYP3A4/3A7, huPXR/huCAR mice
Inducers and treatments:
PCN, RIF, PB, elacridar
Analytical methods:
Hill equation modeling, Michaelis–Menten kinetics, Spearman’s rank correlation
Measured parameters:
Apparent kinetic parameters and pharmacokinetic (PK) parameters
Related figures:
Figure 2, Figure 3, Figure 4, Figure 5
Dose described:
Vemurafenib 100 mg/kg
Statistical notes:
Comparisons between vehicle and treatment groups with significance indicators
Price: 8 / 10 USD
The file will be delivered to the email address provided at checkout within 12 hours.
The file will be delivered to the email address provided at checkout within 12 hours.
Don’t have cryptocurrency yet?
You can still complete your purchase in a few minutes:- Buy Crypto in a trusted app (Coinbase, Kraken, Cash App or any similar service).
- In the app, tap Send.
- Select network, paste our wallet address.
- Send the exact amount shown above.
The final amount may vary slightly depending on the payment method.
The file will be sent to the email address provided at checkout within 24 hours.
The product description is provided for reference. Actual content and formatting may differ slightly.
Document type:
Supplementary table
Title as given:
S_Table 1 The active ingredients of GXNT and their pharmacokinetic parameters
Subject:
Active ingredients of GXNT and pharmacokinetic parameters
Herb names:
SB; LD
Parameters included:
Mol ID; Molecule Name; OB (%); DL
Abbreviations defined:
OB, Oral bioavailability; DL, Drug-likeness
Note:
* No relevant target was found for this compound
Number of listed compounds:
70+
Language of content:
English
Scientific field:
Pharmacology; Phytochemistry
Format:
Tabular dataset
Year:
2026
Region / City:
USA, Irvine, CA
Document Type:
Research Study
Institution:
Chapman University, University of California
Author:
Rudy Chang, Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria
Target Audience:
Researchers, Pharmacologists, Neurologists
Period of Validity:
Ongoing, Preclinical phase
Approval Date:
2026
Modification Date:
Not Applicable
Year:
2023
Region / City:
Nashik, Maharashtra, India
Topic:
RNA therapeutics, clinical pharmacokinetics, RNA-based therapies
Document Type:
Review article
Organization:
Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha, Institute of Pharmaceutical Education & Research
Author:
Sakshi L. Bodke, Mayuri N. Jagtap, Avinash B. Darekar
Target Audience:
Researchers, clinicians, pharmaceutical industry professionals
Period of Validity:
Ongoing
Date of Approval:
2023
Date of Changes:
None
Keywords:
RNA therapeutics, clinical pharmacokinetics, pharmacodynamics, absorption
Note:
Contextual Description
Year:
2021
Region / City:
China and Southeast Asia
Subject:
Pharmacology, Ethnobotany, Phytochemistry
Document Type:
Supplementary material / Scientific review data
Institution:
Chengdu University of Traditional Chinese Medicine
Authors:
Qinyun Du, Xianli Meng, Shaohui Wang
Target Audience:
Researchers and professionals in pharmacology and traditional medicine
Data Coverage:
Plant species, pharmacological activities, extraction methods, and chemical properties
Date of Publication:
2021
References Included:
Yes, multiple sources cited for plant species and pharmacological effects
Language:
English
Document Structure:
Tables with plant sources, pharmacological actions, and extraction methods
Year:
2018
Country:
United States
Subject:
Pharmacokinetics and pharmacodynamics of meropenem in pediatric sepsis
Document Type:
Supplemental scientific tables and figures
Drug:
Meropenem
Pathogen Focus:
Pseudomonas aeruginosa
Data Source:
SENTRY Antimicrobial Surveillance Program
Study Population:
Children younger than 17 years
Clinical Condition:
Sepsis
Parameters Analyzed:
Observed volume of distribution (Vz_obs), observed clearance (Cl_obs), minimum inhibitory concentration (MIC), pharmacodynamic target attainment (T>MIC), estimated glomerular filtration rate (eGFR), fluid balance
Dosage Regimens Evaluated:
20 mg/kg, 40 mg/kg, 60 mg/kg
Evaluation Period:
Day 1 to Day 3 after start of meropenem infusion
Geographic Scope of Isolate Data:
United States medical centers
Year:
2026
Region / city:
European Union
Topic:
Personalized Medicine for Cardiovascular, Metabolic, and Kidney Diseases
Document type:
Pre-proposal application form
Organization / Institution:
European Union Funding Agencies
Author:
Not specified
Target audience:
Research institutions, academic institutions, and industry partners
Duration:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Contextual description:
A pre-proposal application form for the CARMEN2026 joint transnational call for proposals aimed at personalized medicine for cardiovascular, metabolic, and kidney diseases.
Year:
2023
Region / City:
N/A
Subject:
Genetic differentiation, metabolic analysis
Document Type:
Research Supplement
Institution:
N/A
Author:
N/A
Target Audience:
Researchers in genetics and agriculture
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Year:
2023
Region / city:
Not specified
Topic:
Health, Mortality Risk, Body Roundness Index (BRI)
Document type:
Research Supplement
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, Public health professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of modifications:
Not specified
Year:
2023
Region / City:
Beijing, Shenzhen, Manchester, Baltimore
Topic:
Synthetic Biology, Metabolic Engineering, Protein-Protein Interaction
Document Type:
Research Article
Institution:
Tsinghua University, Shenzhen Institutes of Advanced Technology, University of Manchester, Johns Hopkins University
Author:
Tianyi Li, Xiuqi Chen, Yizhi Cai, Junbiao Dai
Target Audience:
Researchers, Biotechnologists, Academics
Effective Date:
2023
Modification Date:
Not specified
Year:
2025
Region / City:
Louisiana
Theme:
Nutrition, Obesity, Metabolic Health
Document Type:
Grant Application Guidelines
Organization:
Pennington Biomedical Research Center
Author:
Not specified
Target Audience:
Early-stage scientists, multidisciplinary teams, post-doctoral fellows
Period of Validity:
2025
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
Hyderabad, Telangana, India
Subject:
Metabolomics, Plasma Profiling, Pre-Diabetes, Non-Diabetic CP Patients
Document Type:
Supplementary Information
Organization / Institution:
Translational Research Centre, Asian Healthcare Foundation, AIG Hospitals, CSIR-Indian Institute of Chemical Technology
Authors:
Ketavarapu Vijayasarathy, Addipilli Ramunaidu, Nagarjunachary Ragi, Pallerla Pavankumar, Venu Simhadri, Suvidha Manne, Sannapaneni Krishnaiah, Mohsin Aslam, Rupjyoti Talukadar, Ch. Venkataramana Devi, G.V. Rao, Ramars Amanchy, D. Nageshwar Reddy, Prabhakar Sripadi, Mitnala Sasikala
Target Audience:
Researchers, Healthcare professionals in metabolomics and diabetes research
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2010-2024
Region / city:
Asia-Pacific
Subject:
Hepatology
Document Type:
Clinical Practice Guidelines
Organization / Institution:
Asian Pacific Association for the Study of the Liver (APASL)
Author:
APASL
Target Audience:
Healthcare professionals
Period of validity:
2010-2024
Date of approval:
2010
Date of revisions:
2024
Context:
Collection of clinical practice guidelines and consensus statements issued by the Asian Pacific Association for the Study of the Liver on various hepatological conditions, including hepatocellular carcinoma, hepatitis B and C, liver transplantation, and metabolic diseases.
Authors:
Luminari S; Donati B; Casali M; Valli R; Santi R; Puccini B; Kovalchuk S; Ruffini A; Fama A; Berti V; Fragliasso V; Zanelli M; Vergoni F; Versari A; Rigacci L; Merli F; Ciarrocchi A
Affiliations:
Hematology Unit, AUSL-IRCCS, Reggio Emilia; University of Modena and Reggio Emilia; Laboratory of Translational Research, AUSL-IRCCS, Reggio Emilia; Nuclear Medicine, AUSL-IRCCS, Reggio Emilia; Pathology Unit, AUSL IRCCS, Reggio Emilia; Pathology Unit, Careggi University Hospital, Firenze; Hematology, AOSP Careggi, Firenze; Gruppo Amici Dell’Ematologia Foundation (GrADE); Nuclear Medicine, University of Firenze; Hematology and Stem Cell Transplant AO San Camillo Forlanini, Roma
Corresponding authors:
Alessia Ciarrocchi; Stefano Luminari
Country:
Italy
Institutions:
AUSL-IRCCS Reggio Emilia; University of Modena and Reggio Emilia; Careggi University Hospital Firenze; University of Firenze; AO San Camillo Forlanini Roma
Medical field:
Hematology; Oncology; Molecular diagnostics
Disease:
Classical Hodgkin Lymphoma
Treatment regimen:
ABVD
Study population:
Previously untreated stage I–IV classical Hodgkin Lymphoma patients
Sample size:
238 patients (121 training set; 117 validation set)
Methodology:
Digital gene expression profiling (NanoString Technology); multivariate regression analysis; five-point Deauville scale assessment
Genes analyzed:
770 immune-related genes
Primary endpoint:
Prediction of interim FDG-PET positivity after two cycles of ABVD
Running title:
Gene predictive model for interim PET in Hodgkin Lymphoma
Keywords:
Hodgkin Lymphoma; metabolic response; interim PET; gene-based predictive model; tumor microenvironment
Word count:
4124
Year:
2023
Region / City:
United States
Topic:
Thrombopoiesis, Metabolic Syndrome, Inflammation, Platelet Counts
Document Type:
Research Article
Organization / Institution:
American University of Beirut, Lebanese University, University of Nicosia
Author:
Ali Hemade, Pascale Salameh
Target Audience:
Healthcare professionals, researchers in hematology and metabolic disorders
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Year:
2025
Location:
Livingston, NJ, USA
Topic:
Metabolic Associated Steatotic Liver Disease (MASLD)
Document Type:
Continuing Medical Education (CME) Program Agenda
Organizing Institution:
Rutgers Health, Rutgers New Jersey Medical School
Departments:
Medicine, Surgery
Audience:
Gastroenterologists, hepatologists, surgeons, endocrinologists, primary care clinicians, nurses, pharmacists, physician assistants
Accreditation:
ACCME, ACPE, ANCC, AAPA
Credits:
4.75 AMA PRA Category 1 Credits™, 4.75 ANCC contact hours, 4.75 CPE contact hours, 4.75 AAPA Category 1 CME Credits
ABIM MOC Points:
Up to 4.75
Date:
Saturday, May 17, 2025
Location Address:
Eisenhower Conference Center, 290 West Mt. Pleasant Ave, Livingston, NJ 07039
Registration URL:
https://rutgers.cloud-cme.com/RUMASLD360
Program Chairs:
Paul J. Gaglio, MD; Faculty includes Kaveh Hajifathalian, MD, MPH; Daniel B. Jones, MD, MS; Bao-Ngoc Nasri, MD, PhD; Danbee H. Kim, MD; Dhvani Doshi, MD, MPH; Zaid Tafesh, MD, MSc
Year:
2026
Region / City:
Lausanne
Topic:
Medical research facilities access
Document type:
Visitor form
Organization:
CIBM EPFL
Author:
Not specified
Target audience:
Researchers and visitors to CIBM EPFL laboratories
Period of validity:
February 2026
Approval date:
Not specified
Modification date:
Not specified
Year:
2018
Region / City:
Colorado, USA
Subject:
Nutritional support / Metabolic formulas
Document Type:
Table / Reference chart
Organization:
Colorado WIC Program
Target Audience:
Infants, children with metabolic disorders, and women participating in WIC
Formula Type:
Powder and concentrate metabolic formulas
Age Groups:
0-3 months, 4-5 months, 6-11 months, 12 months+, women
Date of Issue:
06/01/2018
Source Type:
Government-issued dietary reference
Year:
2023
Region / City:
Not specified
Topic:
Biochemical processes, metabolism, energy production
Document Type:
Educational text
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Students, researchers in biochemistry or related fields
Period of Validity:
Ongoing relevance
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
United States
Topic:
Metabolic and Bariatric Surgery
Document Type:
Application Form
Institution:
American Society for Metabolic and Bariatric Surgery (ASMBS)
Author:
American Society for Metabolic and Bariatric Surgery
Target Audience:
Integrated Health (IH) professionals in metabolic and bariatric surgery
Period of Validity:
N/A
Approval Date:
N/A
Date of Modifications:
N/A