№ files_lp_4_process_1_42026
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Review article on clinical pharmacology and pharmacokinetics of RNA-based therapies, specifically siRNA treatments, highlighting advancements in drug development and their therapeutic potential.
Year:
2023
Region / City:
Nashik, Maharashtra, India
Topic:
RNA therapeutics, clinical pharmacokinetics, RNA-based therapies
Document Type:
Review article
Organization:
Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha, Institute of Pharmaceutical Education & Research
Author:
Sakshi L. Bodke, Mayuri N. Jagtap, Avinash B. Darekar
Target Audience:
Researchers, clinicians, pharmaceutical industry professionals
Period of Validity:
Ongoing
Date of Approval:
2023
Date of Changes:
None
Keywords:
RNA therapeutics, clinical pharmacokinetics, pharmacodynamics, absorption
Note:
Contextual Description
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Document type:
Supplementary table
Title as given:
S_Table 1 The active ingredients of GXNT and their pharmacokinetic parameters
Subject:
Active ingredients of GXNT and pharmacokinetic parameters
Herb names:
SB; LD
Parameters included:
Mol ID; Molecule Name; OB (%); DL
Abbreviations defined:
OB, Oral bioavailability; DL, Drug-likeness
Note:
* No relevant target was found for this compound
Number of listed compounds:
70+
Language of content:
English
Scientific field:
Pharmacology; Phytochemistry
Format:
Tabular dataset
Year:
2026
Region / City:
USA, Irvine, CA
Document Type:
Research Study
Institution:
Chapman University, University of California
Author:
Rudy Chang, Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria
Target Audience:
Researchers, Pharmacologists, Neurologists
Period of Validity:
Ongoing, Preclinical phase
Approval Date:
2026
Modification Date:
Not Applicable
Year:
2021
Region / City:
China and Southeast Asia
Subject:
Pharmacology, Ethnobotany, Phytochemistry
Document Type:
Supplementary material / Scientific review data
Institution:
Chengdu University of Traditional Chinese Medicine
Authors:
Qinyun Du, Xianli Meng, Shaohui Wang
Target Audience:
Researchers and professionals in pharmacology and traditional medicine
Data Coverage:
Plant species, pharmacological activities, extraction methods, and chemical properties
Date of Publication:
2021
References Included:
Yes, multiple sources cited for plant species and pharmacological effects
Language:
English
Document Structure:
Tables with plant sources, pharmacological actions, and extraction methods
Type of document:
Supplementary table legends
Research field:
Pharmacology
Research topic:
Metabolism and pharmacokinetics of vemurafenib
Analyzed compound:
Vemurafenib
Metabolite:
OH-vemurafenib
Biological system:
Human liver microsomes (HLM) and transgenic mouse models
Experimental models:
Cyp3aKO/Cyp3a13+/+, huCYP3A4/3A7, huPXR/huCAR/huCYP3A4/3A7, huPXR/huCAR mice
Inducers and treatments:
PCN, RIF, PB, elacridar
Analytical methods:
Hill equation modeling, Michaelis–Menten kinetics, Spearman’s rank correlation
Measured parameters:
Apparent kinetic parameters and pharmacokinetic (PK) parameters
Related figures:
Figure 2, Figure 3, Figure 4, Figure 5
Dose described:
Vemurafenib 100 mg/kg
Statistical notes:
Comparisons between vehicle and treatment groups with significance indicators
Year:
2018
Country:
United States
Subject:
Pharmacokinetics and pharmacodynamics of meropenem in pediatric sepsis
Document Type:
Supplemental scientific tables and figures
Drug:
Meropenem
Pathogen Focus:
Pseudomonas aeruginosa
Data Source:
SENTRY Antimicrobial Surveillance Program
Study Population:
Children younger than 17 years
Clinical Condition:
Sepsis
Parameters Analyzed:
Observed volume of distribution (Vz_obs), observed clearance (Cl_obs), minimum inhibitory concentration (MIC), pharmacodynamic target attainment (T>MIC), estimated glomerular filtration rate (eGFR), fluid balance
Dosage Regimens Evaluated:
20 mg/kg, 40 mg/kg, 60 mg/kg
Evaluation Period:
Day 1 to Day 3 after start of meropenem infusion
Geographic Scope of Isolate Data:
United States medical centers
Year:
2025
Region / City:
Singapore
Topic:
Target Validation, Drug Discovery
Document Type:
Call for Proposals
Organization:
Singapore Therapeutics Development Review (STDR)
Author:
N/A
Target Audience:
Researchers, Principal Investigators, Institutions
Period of Action:
2025
Approval Date:
N/A
Date of Last Changes:
N/A
Year:
2024
Region:
Africa
Document type:
Call for Expression of Interest (EOI)
Issuing organizations:
Africa CDC, Unitaid
Target audience:
Pharmaceutical manufacturers, CDMOs, CROs in Africa
Programmatic focus:
Maternal health, malaria, HIV, and related co-infections
Submission deadline:
August 15, 2024
Question deadline:
July 30, 2024
Issue date:
July 8, 2024
Supported interventions:
Safe Birth Africa project co-funded by European Union
Scope:
Regional manufacturing of therapeutics, diagnostics, and APIs
Product categories:
Oral solid dosage forms, sterile injectables, APIs
Year:
Not specified
Region / city:
Not specified
Theme:
Parkinson’s disease, therapeutic research
Document Type:
Pre-Clinical Proposal Template
Organization / Institution:
Michael J. Fox Foundation
Author:
Not specified
Period of validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Date:
April 22nd, 2025
Region / City:
Paris, France
Subject:
Immuno-oncology, Biotechnology
Document Type:
Press Release
Organization / Institution:
Egle Therapeutics
Author:
Egle Therapeutics
Target Audience:
Medical and scientific professionals in immuno-oncology and biotechnology
Period of Activity:
2025
Date of Approval:
April 22nd, 2025
Date of Changes:
N/A
Year:
Not specified
Region / city:
Not specified
Document Type:
Request for Applications
Organization / institution:
Not specified
Author:
Not specified
Target audience:
Researchers in Parkinson’s disease therapeutics
Period of validity:
Not specified
Approval date:
Not specified
Amendment date:
Not specified
Year:
2024
Region / city:
United States
Subject:
COVID-19 therapeutics development
Document type:
Request for Proposals (RFP)
Organ / institution:
Biomedical Advanced Research and Development Authority (BARDA)
Author:
Biomedical Advanced Research and Development Authority (BARDA)
Target audience:
Product developers, biomedical organizations
Period of validity:
2024–2027
Approval date:
05 August 2024
Amendment date:
20 August 2024
Note:
Year
Topic:
Neurology, Parkinson’s Disease
Document Type:
Request for Applications
Note:
Year
Subject:
Gene Transfer, Targeting, and Therapeutics
Document Type:
Request Form
Organization / Institution:
Salk Institute
Target Audience:
Researchers and Lab personnel
Context:
A form for requesting viral vectors from the Gene Transfer, Targeting, and Therapeutics Facility at the Salk Institute for scientific research purposes.
Year:
2026
Region / City:
La Jolla, CA
Topic:
Gene Transfer, Viral Vectors
Document Type:
Request Form
Organization / Institution:
Salk Institute for Biological Studies
Author:
GT3 Core Facility
Target Audience:
Researchers, Investigators
Validity Period:
N/A
Approval Date:
N/A
Modification Date:
N/A
Year:
2013
Region / city:
Gauteng Province
Theme:
Pharmaceuticals, Therapeutics, Rational Medicine Use
Document type:
Educational material
Institution:
Management Sciences for Health (MSH)
Author:
Management Sciences for Health
Target audience:
Healthcare practitioners, policy makers, and managers
Period of validity:
Indefinite
Approval date:
Not specified
Date of changes:
Not specified
Year:
2024
Region / city:
United States
Theme:
Gastrointestinal pharmacology, infectious diseases, antibiotic resistance, healthcare management
Document Type:
Review
Institution:
Hackensack Palisades Medical Center, Augusta University
Author:
Nagesh VK, Tran HHV, Elias D, Kianifar Aguilar I, Sethi T, Menon A, Mansour C, Furman F, Tsotsos K, Subar T, Auda A, Sidiqui A, Lamar J, Wadhwani N, Dey S, Lo A, Atoot A, Weissman S, Sifuentes H, Bangolo AI
Target Audience:
Healthcare professionals, researchers, medical practitioners
Period of Validity:
Ongoing studies, review is relevant until new treatments emerge
Date of Approval:
2024-07-25
Date of Changes:
2024-07-21
Facility:
Gene Transfer, Targeting and Therapeutics Facility
Institution:
Salk Institute for Biological Studies
Document Type:
Viral Vector Request Form
Subject:
Stock Reporter Viral Vectors
Submission Method:
Email to [email protected]
Required Information:
Principal Investigator, Lab Contact, Order Date, Fund Number or PO Number, Billing and Shipping Address
Aliquot Size AAV:
25 µl
Aliquot Size Lentiviral, Retroviral, Rabies:
5 µl
Vector Categories:
rAAV, Cre, DIO, FLEX, DO, Lentivirus, AAV Serotype Kits
Source References:
Addgene; Deisseroth Lab (Stanford University)
Material Transfer Requirement:
MTA required for Deisseroth Lab vectors
Titer Information:
Representative lot titers provided; actual titers may vary
Year:
2015
Region / City:
Southeastern/Southwest United States
Field:
Medicine, Oncology
Document Type:
Abstract
Organization:
Texas Tech University Health Sciences Center, University of Pennsylvania
Author:
Paul Trippier, Kshitij Verma, Tianzhu Zang, Trevor M. Penning
Target Audience:
Researchers, Medical Professionals
Effective Period:
Not specified
Approval Date:
Not specified
Date of Last Update:
Not specified