№ files_lp_4_process_3_120065
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Supplementary pharmacokinetic and pharmacodynamic data tables and figures presenting analyses of meropenem distribution, clearance, dosing simulations, and therapeutic concentration attainment in children with sepsis, including susceptibility data for Pseudomonas aeruginosa isolates from U.S. surveillance.
Year: 2018
Country: United States
Subject: Pharmacokinetics and pharmacodynamics of meropenem in pediatric sepsis
Document Type: Supplemental scientific tables and figures
Drug: Meropenem
Pathogen Focus: Pseudomonas aeruginosa
Data Source: SENTRY Antimicrobial Surveillance Program
Study Population: Children younger than 17 years
Clinical Condition: Sepsis
Parameters Analyzed: Observed volume of distribution (Vz_obs), observed clearance (Cl_obs), minimum inhibitory concentration (MIC), pharmacodynamic target attainment (T>MIC), estimated glomerular filtration rate (eGFR), fluid balance
Dosage Regimens Evaluated: 20 mg/kg, 40 mg/kg, 60 mg/kg
Evaluation Period: Day 1 to Day 3 after start of meropenem infusion
Geographic Scope of Isolate Data: United States medical centers
Price: 8 / 10 USD
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Pharmacodynamic Modeling of Sunscreens: New Efficacy Evaluation, Risks of Sunburn and Melanoma and Very Low to Very High Sun Protection Factor
Year: 2020
Region / city: United States, Illinois
Theme: Sunscreen efficacy, sunburn, melanoma, skin protection
Document type: Academic article
Organization / institution: Chiou Consulting Inc, National Institutes of Health
Author: Win L. Chiou
Target audience: Researchers, healthcare professionals, public health experts
Effective period: 2020
Approval date: March 27, 2020
Modification date: Not specified
Keywords: sunscreen, sunburn, melanoma, skin aging/antiaging theory, UV Index, skin cancers
S_Table 1 The Active Ingredients of GXNT and Their Pharmacokinetic Parameters
Document type: Supplementary table
Title as given: S_Table 1 The active ingredients of GXNT and their pharmacokinetic parameters
Subject: Active ingredients of GXNT and pharmacokinetic parameters
Herb names: SB; LD
Parameters included: Mol ID; Molecule Name; OB (%); DL
Abbreviations defined: OB, Oral bioavailability; DL, Drug-likeness
Note: * No relevant target was found for this compound
Number of listed compounds: 70+
Language of content: English
Scientific field: Pharmacology; Phytochemistry
Format: Tabular dataset
Longitudinal pharmacokinetic and safety studies for dose optimization of a brain-penetrating erythropoietin for Alzheimer’s disease
Year: 2026
Region / City: USA, Irvine, CA
Document Type: Research Study
Institution: Chapman University, University of California
Author: Rudy Chang, Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria
Target Audience: Researchers, Pharmacologists, Neurologists
Period of Validity: Ongoing, Preclinical phase
Approval Date: 2026
Modification Date: Not Applicable
RNA THERAPEUTICS: CLINICAL PHARMACOKINETIC AND THERAPEUTIC MONITORING
Year: 2023
Region / City: Nashik, Maharashtra, India
Topic: RNA therapeutics, clinical pharmacokinetics, RNA-based therapies
Document Type: Review article
Organization: Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha, Institute of Pharmaceutical Education & Research
Author: Sakshi L. Bodke, Mayuri N. Jagtap, Avinash B. Darekar
Target Audience: Researchers, clinicians, pharmaceutical industry professionals
Period of Validity: Ongoing
Date of Approval: 2023
Date of Changes: None
Keywords: RNA therapeutics, clinical pharmacokinetics, pharmacodynamics, absorption
Note: Contextual Description
Supplementary Materials for a Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine
Year: 2021
Region / City: China and Southeast Asia
Subject: Pharmacology, Ethnobotany, Phytochemistry
Document Type: Supplementary material / Scientific review data
Institution: Chengdu University of Traditional Chinese Medicine
Authors: Qinyun Du, Xianli Meng, Shaohui Wang
Target Audience: Researchers and professionals in pharmacology and traditional medicine
Data Coverage: Plant species, pharmacological activities, extraction methods, and chemical properties
Date of Publication: 2021
References Included: Yes, multiple sources cited for plant species and pharmacological effects
Language: English
Document Structure: Tables with plant sources, pharmacological actions, and extraction methods
Supplementary Table Legends for Pharmacokinetic and Metabolic Analyses of Vemurafenib
Type of document: Supplementary table legends
Research field: Pharmacology
Research topic: Metabolism and pharmacokinetics of vemurafenib
Analyzed compound: Vemurafenib
Metabolite: OH-vemurafenib
Biological system: Human liver microsomes (HLM) and transgenic mouse models
Experimental models: Cyp3aKO/Cyp3a13+/+, huCYP3A4/3A7, huPXR/huCAR/huCYP3A4/3A7, huPXR/huCAR mice
Inducers and treatments: PCN, RIF, PB, elacridar
Analytical methods: Hill equation modeling, Michaelis–Menten kinetics, Spearman’s rank correlation
Measured parameters: Apparent kinetic parameters and pharmacokinetic (PK) parameters
Related figures: Figure 2, Figure 3, Figure 4, Figure 5
Dose described: Vemurafenib 100 mg/kg
Statistical notes: Comparisons between vehicle and treatment groups with significance indicators
Topics: Meropenem Pharmacodynamic Pharmacokinetic