№ files_lp_4_process_2_60428
File format: docx Character count: 40563 File size: 58 KB
Year: 2021
Region / City: China and Southeast Asia
Subject: Pharmacology, Ethnobotany, Phytochemistry
Document Type: Supplementary material / Scientific review data
Institution: Chengdu University of Traditional Chinese Medicine
Authors: Qinyun Du, Xianli Meng, Shaohui Wang
Target Audience: Researchers and professionals in pharmacology and traditional medicine
Data Coverage: Plant species, pharmacological activities, extraction methods, and chemical properties
Date of Publication: 2021
References Included: Yes, multiple sources cited for plant species and pharmacological effects
Language: English
Document Structure: Tables with plant sources, pharmacological actions, and extraction methods
Price: 8 / 10 USD
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Disposition of Peer Review Comments for Toxicological Profile for JP-5, JP-8, and Jet A Fuels (September 2015)
Year: 2015
Month: September
Country: United States
Issuing Body: U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry
Document Type: Disposition of Peer Review Comments
Subject: Toxicological evaluation of JP-5, JP-8, and Jet A fuels
Related Document: Toxicological Profile for JP-5, JP-8, and Jet A Fuels
Peer Review Stage: Third pre-public comment draft
Peer Reviewers: Errol Zeiger, Ph.D., J.D., A.T.S.E.; Luis Haro Garcia, M.D., MSc, Ph.D.; Wayne G. Landis, Ph.D.
Geographic References: Chapel Hill, North Carolina; México DF, México; Bellingham, Washington
Intended Audience: Health assessors; general public (Chapter 1); scientific reviewers
Regulatory References: ASTM specifications; NIOSH recommended exposure limit
Topical Areas: Public health statement; relevance to public health; health effects; exposure assessment; NOAEL and LOAEL evaluation; inhalation studies; fate and transport; contaminated sites
Toxicological Evaluation of Microplastic Extracts in Zebrafish Behavior By Light–Dark and Startle Response Assays
Year: 2024
Region / City: Chennai
Subject: Toxicology, Environmental Pollution, Microplastics
Document Type: Research Article
Organization / Institution: Not specified
Author: Not specified
Target Audience: Researchers, Environmental Scientists
Period of Validity: Not specified
Approval Date: Not specified
Date of Amendments: Not specified
S_Table 1 The Active Ingredients of GXNT and Their Pharmacokinetic Parameters
Document type: Supplementary table
Title as given: S_Table 1 The active ingredients of GXNT and their pharmacokinetic parameters
Subject: Active ingredients of GXNT and pharmacokinetic parameters
Herb names: SB; LD
Parameters included: Mol ID; Molecule Name; OB (%); DL
Abbreviations defined: OB, Oral bioavailability; DL, Drug-likeness
Note: * No relevant target was found for this compound
Number of listed compounds: 70+
Language of content: English
Scientific field: Pharmacology; Phytochemistry
Format: Tabular dataset
Longitudinal pharmacokinetic and safety studies for dose optimization of a brain-penetrating erythropoietin for Alzheimer’s disease
Year: 2026
Region / City: USA, Irvine, CA
Document Type: Research Study
Institution: Chapman University, University of California
Author: Rudy Chang, Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria
Target Audience: Researchers, Pharmacologists, Neurologists
Period of Validity: Ongoing, Preclinical phase
Approval Date: 2026
Modification Date: Not Applicable
RNA THERAPEUTICS: CLINICAL PHARMACOKINETIC AND THERAPEUTIC MONITORING
Year: 2023
Region / City: Nashik, Maharashtra, India
Topic: RNA therapeutics, clinical pharmacokinetics, RNA-based therapies
Document Type: Review article
Organization: Krantiveer Vasantrao Narayanrao Naik Shikshan Prasarak Sanstha, Institute of Pharmaceutical Education & Research
Author: Sakshi L. Bodke, Mayuri N. Jagtap, Avinash B. Darekar
Target Audience: Researchers, clinicians, pharmaceutical industry professionals
Period of Validity: Ongoing
Date of Approval: 2023
Date of Changes: None
Keywords: RNA therapeutics, clinical pharmacokinetics, pharmacodynamics, absorption
Note: Contextual Description
Supplementary Table Legends for Pharmacokinetic and Metabolic Analyses of Vemurafenib
Type of document: Supplementary table legends
Research field: Pharmacology
Research topic: Metabolism and pharmacokinetics of vemurafenib
Analyzed compound: Vemurafenib
Metabolite: OH-vemurafenib
Biological system: Human liver microsomes (HLM) and transgenic mouse models
Experimental models: Cyp3aKO/Cyp3a13+/+, huCYP3A4/3A7, huPXR/huCAR/huCYP3A4/3A7, huPXR/huCAR mice
Inducers and treatments: PCN, RIF, PB, elacridar
Analytical methods: Hill equation modeling, Michaelis–Menten kinetics, Spearman’s rank correlation
Measured parameters: Apparent kinetic parameters and pharmacokinetic (PK) parameters
Related figures: Figure 2, Figure 3, Figure 4, Figure 5
Dose described: Vemurafenib 100 mg/kg
Statistical notes: Comparisons between vehicle and treatment groups with significance indicators
Supplemental Digital Content: Pharmacokinetic and Pharmacodynamic Analyses of Meropenem in Pediatric Patients with Sepsis
Year: 2018
Country: United States
Subject: Pharmacokinetics and pharmacodynamics of meropenem in pediatric sepsis
Document Type: Supplemental scientific tables and figures
Drug: Meropenem
Pathogen Focus: Pseudomonas aeruginosa
Data Source: SENTRY Antimicrobial Surveillance Program
Study Population: Children younger than 17 years
Clinical Condition: Sepsis
Parameters Analyzed: Observed volume of distribution (Vz_obs), observed clearance (Cl_obs), minimum inhibitory concentration (MIC), pharmacodynamic target attainment (T>MIC), estimated glomerular filtration rate (eGFR), fluid balance
Dosage Regimens Evaluated: 20 mg/kg, 40 mg/kg, 60 mg/kg
Evaluation Period: Day 1 to Day 3 after start of meropenem infusion
Geographic Scope of Isolate Data: United States medical centers
Topics: Tetrahydropalmatine Toxicological Pharmacokinetic