№ files_lp_3_process_7_021196
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Clostridium difficile infection (CDI) and its management through antibiotics, monoclonal antibodies, and fecal microbiota transplant have become central to healthcare strategies, particularly concerning recurrent infections in high-risk populations.
Year:
2024
Region / city:
United States
Theme:
Gastrointestinal pharmacology, infectious diseases, antibiotic resistance, healthcare management
Document Type:
Review
Institution:
Hackensack Palisades Medical Center, Augusta University
Author:
Nagesh VK, Tran HHV, Elias D, Kianifar Aguilar I, Sethi T, Menon A, Mansour C, Furman F, Tsotsos K, Subar T, Auda A, Sidiqui A, Lamar J, Wadhwani N, Dey S, Lo A, Atoot A, Weissman S, Sifuentes H, Bangolo AI
Target Audience:
Healthcare professionals, researchers, medical practitioners
Period of Validity:
Ongoing studies, review is relevant until new treatments emerge
Date of Approval:
2024-07-25
Date of Changes:
2024-07-21
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Year:
2016
Region / City:
London, Swindon, Berkshire, Merseyside, Yorkshire, Sunderland
Topic:
Clostridium difficile infection, hospital infection control
Document Type:
Research article
Organization:
Guy’s & St Thomas’ NHS Foundation Trust, Great Western Hospitals NHS Foundation Trust, Heatherwood and Wexham Park Hospitals NHS Foundation Trust, St Helens & Knowsley Hospitals NHS Trust, Calderdale & Huddersfield NHS Foundation Trust, City Hospitals Sunderland NHS Foundation Trust
Author:
Not specified
Target Audience:
Healthcare professionals, researchers
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Context:
A research article detailing the comparison of C. difficile infection control measures across six hospitals in England using whole-genome sequencing to track transmission patterns.
Year:
2026
Region / City:
United States
Topic:
Healthcare, Infection Control, Long-Term Care Facilities
Document Type:
Guidelines
Organization:
Centers for Disease Control and Prevention (CDC)
Author:
Not specified
Target Audience:
Healthcare professionals in Long-Term Care Facilities (LTCFs)
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Revisions:
Not specified
Year:
2023
Region / city:
Minnesota
Topic:
Infection Prevention and Control
Document type:
Policy
Organization / institution:
Minnesota Department of Health
Author:
Unknown
Target audience:
Healthcare workers and medical staff
Period of validity:
Not specified
Approval date:
Not specified
Review date:
Not specified
Date of changes:
Not specified
Treatment protocols:
Polymerase chain reaction (PCR) testing preferred over enzyme immunoassay (EIA) tests
Environmental cleaning requirements:
Daily cleaning and disinfection of rooms
Hand hygiene requirements:
Soap and water preferred, alcohol-based hand rubs acceptable
Contact precautions:
Required for suspected CDI residents
Room placement:
Private rooms preferred
Laundry protocol:
Contaminated laundry to be disinfected
Treatment:
Antibiotic stewardship important
Notes:
Regular updates and specific protocols for testing and care
Year:
2023
Region / City:
N/A
Topic:
Clostridium difficile, Fecal Transplants, Antibiotics
Document Type:
Research Article
Institution:
N/A
Author:
N/A
Target Audience:
Medical professionals, Researchers, Healthcare providers
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2017
Region / city:
United Kingdom
Subject:
Faecal microbiota transplant (FMT) for Clostridium difficile infection and other indications
Document type:
Clinical guidelines
Organization / institution:
British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS)
Authors:
Working group of BSG and HIS
Target audience:
Healthcare professionals, clinicians
Period of validity:
Ongoing (as of publication)
Approval date:
Not specified
Date of revisions:
Not specified
Scope:
Guidelines for the use of faecal microbiota transplant in treating Clostridium difficile infection (CDI) and other clinical conditions
Clinical management:
Recommendations for patient selection, donor selection, and FMT administration
Economic aspects:
Cost-effectiveness of FMT compared to traditional therapies for CDI
Year:
2023
Region / City:
Unknown
Topic:
Gestational Diabetes, Gut Microbiota, Newborns
Document Type:
Research Study
Author:
Unknown
Target Audience:
Researchers, Healthcare Professionals
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
Hertfordshire
Topic:
Healthcare, Infectious Diseases
Document Type:
Case Review Template
Organ / Institution:
NHS
Author:
Not specified
Target Audience:
Healthcare providers, General Practitioners
Period of Action:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2016
Region / City:
London, Swindon, Berkshire, Merseyside, Yorkshire, Sunderland
Topic:
Clostridium difficile infection, hospital infection control
Document Type:
Research article
Organization:
Guy’s & St Thomas’ NHS Foundation Trust, Great Western Hospitals NHS Foundation Trust, Heatherwood and Wexham Park Hospitals NHS Foundation Trust, St Helens & Knowsley Hospitals NHS Trust, Calderdale & Huddersfield NHS Foundation Trust, City Hospitals Sunderland NHS Foundation Trust
Author:
Not specified
Target Audience:
Healthcare professionals, researchers
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Context:
A research article detailing the comparison of C. difficile infection control measures across six hospitals in England using whole-genome sequencing to track transmission patterns.
Year:
2026
Region / City:
United States
Topic:
Healthcare, Infection Control, Long-Term Care Facilities
Document Type:
Guidelines
Organization:
Centers for Disease Control and Prevention (CDC)
Author:
Not specified
Target Audience:
Healthcare professionals in Long-Term Care Facilities (LTCFs)
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Revisions:
Not specified
Year:
2023
Region / city:
Minnesota
Topic:
Infection Prevention and Control
Document type:
Policy
Organization / institution:
Minnesota Department of Health
Author:
Unknown
Target audience:
Healthcare workers and medical staff
Period of validity:
Not specified
Approval date:
Not specified
Review date:
Not specified
Date of changes:
Not specified
Treatment protocols:
Polymerase chain reaction (PCR) testing preferred over enzyme immunoassay (EIA) tests
Environmental cleaning requirements:
Daily cleaning and disinfection of rooms
Hand hygiene requirements:
Soap and water preferred, alcohol-based hand rubs acceptable
Contact precautions:
Required for suspected CDI residents
Room placement:
Private rooms preferred
Laundry protocol:
Contaminated laundry to be disinfected
Treatment:
Antibiotic stewardship important
Notes:
Regular updates and specific protocols for testing and care
Year:
2023
Region / City:
N/A
Topic:
Clostridium difficile, Fecal Transplants, Antibiotics
Document Type:
Research Article
Institution:
N/A
Author:
N/A
Target Audience:
Medical professionals, Researchers, Healthcare providers
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Note:
Year
Theme:
Microbiology, Pathogen Studies
Document Type:
Scientific protocol
Target Audience:
Researchers, Laboratory Professionals
Year:
2026
Region / City:
Rochester, MN, USA
Topic:
Microbiome modulation in Clostridioides difficile infection
Document Type:
Clinical trial report
Institution:
Mayo Clinic; Rebiotix Inc; BioRankings LLC
Authors:
Sahil Khanna, MBBS; Darrell S. Pardi, MD; Courtney Jones; William D. Shannon, PhD, MBA; Carlos Gonzalez, MS; Ken Blount, PhD
Target Audience:
Medical researchers, gastroenterologists, microbiologists
Study Phase:
Phase 1
Treatment:
RBX7455 orally administered live biotherapeutic
Sample Type:
Fecal samples from study participants
Outcome Measures:
Safety, efficacy, microbiome composition shifts
Time Points:
Baseline, Day 1, Week 1, Week 4, Week 8, Week 12, Week 24
Analysis Methods:
Dirichlet multinomial fitting, repeated measures analysis (DMRepeat)
Publication References:
La Rosa PS et al., PLoS One 2012; Shannon WD, BioRankings Technical Report #3
Year:
2017
Region / city:
United Kingdom
Subject:
Faecal microbiota transplant (FMT) for Clostridium difficile infection and other indications
Document type:
Clinical guidelines
Organization / institution:
British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS)
Authors:
Working group of BSG and HIS
Target audience:
Healthcare professionals, clinicians
Period of validity:
Ongoing (as of publication)
Approval date:
Not specified
Date of revisions:
Not specified
Scope:
Guidelines for the use of faecal microbiota transplant in treating Clostridium difficile infection (CDI) and other clinical conditions
Clinical management:
Recommendations for patient selection, donor selection, and FMT administration
Economic aspects:
Cost-effectiveness of FMT compared to traditional therapies for CDI
Year:
2023
Region / City:
Hertfordshire
Topic:
Healthcare, Infectious Diseases
Document Type:
Case Review Template
Organ / Institution:
NHS
Author:
Not specified
Target Audience:
Healthcare providers, General Practitioners
Period of Action:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Protocol version:
6.0
Date:
18 September 2020
Study name:
rEECur
Study design:
International randomised controlled trial
Medical condition:
Recurrent and primary refractory Ewing sarcoma
Intervention:
Chemotherapy
Sponsor:
University of Birmingham
Sponsor protocol number:
RG_13-277
CRCTU number:
SA2015
EudraCT number:
2014-000259-99
ISRCTN reference number:
ISRCTN36453794
Chief Investigator:
Dr Martin McCabe
Coordinating institution:
Cancer Research UK Clinical Trials Unit, University of Birmingham
Geographic scope:
International
Participating regions:
United Kingdom, Germany, Italy, France, Spain, Scandinavia, Australia, New Zealand, Switzerland
Target population:
Patients with recurrent or primary refractory Ewing sarcoma
Regulatory status:
Ethics and regulatory approval required per participating country
Amendment history:
Substantial amendments between 2014 and 2016
Document type:
Clinical trial protocol
Randomisation method:
Centralised online randomisation
Trial phase:
Phase II (Germany-specific limitation noted)
Year:
2024
Region / city:
Global
Theme:
Oncology, Endometrial Cancer, Pharmaceutical Submissions
Document Type:
Medical Submission
Organization / Institution:
AstraZeneca Pty Ltd
Author:
AstraZeneca Pty Ltd
Target Audience:
Medical professionals, regulatory bodies, pharmaceutical companies
Period of validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2022
Country:
Australia
Therapeutic area:
Oncology
Disease:
Endometrial cancer
Biomarker status:
Mismatch repair deficient (dMMR)
Medicine name:
Dostarlimab
Brand name:
Jemperli
Dosage form:
Solution concentrate for intravenous infusion
Sponsor:
GlaxoSmithKline Australia Pty Ltd
Regulatory body:
Pharmaceutical Benefits Advisory Committee
Submission type:
Standard Re-entry submission
Requested listing:
Section 100
Comparator treatments:
Standard of care chemotherapy; pembrolizumab plus lenvatinib; pembrolizumab monotherapy
Clinical trial referenced:
GARNET
Approval status:
Provisional approval
Indication:
Recurrent or advanced endometrial cancer after platinum-containing regimen
Decision context:
PBS listing consideration
Period covered:
Up to November 2022
Year:
2023
Region / city:
Aarhus, Denmark
Topic:
Psychiatry, Genetics
Document Type:
Research Supplement
Institution:
iPSYCH Research Initiative, Aarhus University
Author:
iPSYCH Investigators
Target Audience:
Researchers, Geneticists, Psychiatrists
Period of validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2021
Region / City:
Not specified
Theme:
Health, Medicine
Document Type:
Medical Guidance
Organization:
Not specified
Author:
Not specified
Target Audience:
Patients on long-term steroid therapy
Period of Validity:
Not specified
Date of Approval:
Not specified
Date of Changes:
Not specified