№ lp_2_3_03788
File format: docx
Character count: 47147
File size: 37 KB
Mitochondrial genome editing technologies, including nucleases and base editors, are being developed to address mitochondrial diseases by precisely targeting and modifying mtDNA mutations.
Year:
2024
Region / city:
Global
Topic:
Mitochondrial genetics, gene editing technologies, therapeutic potential
Document type:
Scientific article
Institution:
Not specified
Author:
Gizem INAL
Target audience:
Researchers, clinicians, and medical professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Price: 8 / 10 USD
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Authors:
Noemi Pasini; Marta Bassitta; Joana F. Ferragut; Maria Teresa Farriols; Natalia Petit-Marty; Francesc Ordinas; Sergio Ramírez-Amaro; Antònia Picornell
Corresponding author:
Sergio Ramírez-Amaro ([email protected]
Note:
)
Affiliations:
Universitat de les Illes Balears; Instituto Español de Oceanografía, Centre Oceanogràfic de les Balears; Institute of Marine Research (IIM-CSIC)
Geographical area:
Menorca Channel, Western Mediterranean Sea
Year of FPZ establishment analyzed:
2016
Subject:
Genetic diversity and fisheries conservation
Keywords:
Nucleotide diversity; COI; Coalescent simulations; Fisheries resources; Protected areas; Mediterranean Sea
Type of document:
Scientific research article
Study focus:
Assessment of mitochondrial COI genetic diversity in exploited marine species inside and outside a Fisheries Protection Zone
Methodology:
Mitochondrial DNA analysis and coalescent simulations
Species scope:
Four exploited marine species
Data sources:
MEDITS and CANAL surveys; Vessel Monitoring System (VMS) data
Year:
Not specified
Region / Country:
China
City:
Shenzhen
Field:
Oncology; Molecular Biology; Bioinformatics
Research Topic:
Nasopharyngeal carcinoma prognosis and gene expression analysis
Document Type:
Scientific research article
Institutions:
Shenzhen University General Hospital; Shenzhen Hospital of Southern Medical University
Departments:
Department of Otolaryngology Head and Neck Surgery; Department of Urology; Department of Anesthesiology
Authors:
Ping Li; Xin Xu; Xueyu Zhang; Huifen Xie; Cuirong Xiao; Yinggui Yang
Corresponding Author:
Yinggui Yang
Ethics Approval:
Ethics Committee of Affiliated Shenzhen Hospital of Southern Medical University
Methodology:
Transcriptomic data analysis; univariate Cox regression; risk model construction; nomogram; gene set enrichment analysis; immune infiltration analysis; drug sensitivity analysis
Key Genes Identified:
ARHGAP4; MEIS1; XCR1
Disease Focus:
Nasopharyngeal carcinoma
Associated Factors:
Epstein-Barr virus infection; mitochondrial dynamics
Data Source:
Public biological databases
Research Objective:
Identification of prognostic genes and development of a predictive risk model for nasopharyngeal carcinoma
Keywords:
Nasopharyngeal carcinoma; Prognostic genes; Risk model; Epstein-Barr virus
Year:
2024
Region / city:
Global
Subject:
Radiotherapy, Cancer Research
Document type:
Research article
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, Oncology professionals
Period of validity:
N/A
Approval date:
Not specified
Modification date:
Not specified
Year:
2006
Field:
Molecular Biology
Document type:
Research Article
Authors:
Paulina Wegrzyn, Stephen J Yarwood, Nathalie Fiegler, et al.
Organ / Institution:
Not specified
Target audience:
Researchers in molecular biology and biochemistry
Experimental model:
HepG2 cells, primary rat hepatocytes
Key molecules:
Mimitin, IL-1, IL-6
Methodology:
Gene expression analysis, luciferase reporter assay
Findings:
Cytokines IL-1 and IL-6 upregulate mimitin expression at transcriptional level
Year:
Not specified
Region / Country:
Not specified
Subject:
Mitochondrial genome sequencing and genetic diagnostics
Document Type:
Medical necessity letter template
Organization:
Not specified
Author:
Not specified
Target Audience:
Healthcare providers and insurance reviewers
Clinical Context:
Suspected mitochondrial disease
Purpose:
Justification for genetic testing based on clinical and family history
Medical Focus:
Genetic testing, mitochondrial disorders, diagnostic strategy
Referenced Guidelines:
Mitochondrial Medicine Society (2015), United Kingdom best practice guidelines (2023)
Testing Method:
Next-generation sequencing, mitochondrial genome sequencing
Evidence Base:
Peer-reviewed scientific literature and clinical guidelines
Patient Information:
Clinical findings, family history, prior testing results
Intended Outcome:
Diagnostic clarification and guidance for clinical management
Year:
2021
Region / City:
Australia
Subject:
Regulation Impact Statement
Document Type:
Official Correspondence
Organization / Institution:
Department of Health
Author:
Jason Lange
Target Audience:
Government officials, policy makers
Period of Validity:
Indefinite
Approval Date:
6 April 2021
Date of Last Change:
6 April 2021
Year:
2026
Region / City:
Liverpool, United Kingdom; Beerse, Belgium; Spring House, PA, USA; Cambridge, United Kingdom
Subject:
Drug-induced liver injury; Mitochondrial toxicity; Hepatic cell models
Document type:
Research article
Institution / Organization:
MRC Centre for Drug Safety Science, University of Liverpool; Janssen Research and Development; AstraZeneca
Authors:
Laleh Kamalian, Oisin Douglas, Carol Jolly, Jan Snoeys, Damir Simic, Mario Monshouwer, Dominic P. Williams, B. Kevin Park, Amy E. Chadwick
Corresponding author:
Laleh Kamalian
Keywords:
mitochondria, HepaRG, HepG2, seahorse respirometry, bioenergetic phenotype, drug-induced liver injury
Methodology:
In vitro cell line study, Seahorse respirometry, acute metabolic modification assay, bioenergetic phenotyping
Main findings:
HepaRG cells display lower basal metabolic activity than HepG2 but reliably detect mitochondrial toxicity; compounds classified as inhibitors or uncouplers of electron transport chain
Cell lines:
HepaRG, HepG2
Experimental period:
2026
Publication type:
Peer-reviewed scientific study
Language:
English
Note:
en
Year:
2014
Topic:
Academic publishing, editing, and manuscript preparation
Document type:
Guidelines for authors
Organization / Institution:
IGI Global
Target audience:
Authors and editors preparing academic chapters for publication
Year:
Not specified
Region / City:
Not specified
Theme:
Wood doors specification for construction projects
Document Type:
Specification
Organization / Institution:
Simpson Door Company
Author:
Not specified
Target Audience:
Designers and builders
Period of validity:
Not specified
Approval Date:
Not specified
Date of amendments:
Not specified
Year:
2026
Organization:
IQNavigator
Audience:
Hiring Manager and Program Office staff
Document Type:
Procedure/Instruction
Scope:
Assignment lifecycle management
Topics:
Assignment edits, contract amendments, onboarding checklist, assignment closure
Effective Date:
2026-02-05
Year:
2016
Region / City:
United States
Topic:
IT Services, Veterans Affairs
Document Type:
Performance Work Statement (PWS)
Agency / Organization:
Department of Veterans Affairs, Veterans Health Administration
Author:
Not specified
Target Audience:
Contractors, Veterans Affairs personnel
Period of Effectiveness:
2016-2017
Approval Date:
May 11, 2016
Date of Changes:
Not specified
Year:
2010
Region / City:
Not specified
Subject:
Microsoft Word 2010 Editing Tools
Document Type:
Training Material
Organization:
Not specified
Author:
Not specified
Target Audience:
Adults
Duration:
90 minutes
Period of Activity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Equipment Requirements:
Projector, computers with internet connections, laser pointer
Software Requirements:
Windows 7, Microsoft Word 2010
Material Requirements:
Pens, activity sheets, practice files, handouts, surveys
Learning Objectives:
Cut, copy, paste text, find and replace text, use thesaurus and grammar check
Assessment Method:
Completion of class activities
Agenda:
Outline class content
Note:
Context
Year:
2019
Region / City:
Purdue University
Topic:
Timekeeping Instructions
Document Type:
Cheat Sheet
Institution:
Purdue University
Author:
Purdue University
Target Audience:
Purdue Employees
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
3/20/2019
Year:
2024
Region / City:
Toronto, Canada
Topic:
Editing, Professional Writing, Publishing
Document Type:
Syllabus, Course Outline
Organization:
York University, Faculty of Liberal Arts and Professional Studies
Author:
Dr. Matt Bucemi
Target Audience:
Students of PRWR 2006
Period of Action:
Winter 2024
Approval Date:
N/A
Revision Date:
N/A
Year:
2023
Organization:
International Telecommunication Union
Sector:
ITU Telecommunication Standardization Sector (ITU-T)
Publication type:
Informative publication
Document type:
Author’s guide
Approval body:
Telecommunication Standardization Advisory Group (TSAG)
Revision date:
June 2023
Scope:
Preparation and presentation of ITU-T Recommendations
Intended users:
ITU-T study group authors
Language:
English
Copyright holder:
International Telecommunication Union
Rights:
All rights reserved
Year:
2015
Region / City:
Raleigh, North Carolina
Theme:
Sales, Training, Business Communication
Document Type:
Letter
Organization / Institution:
Quality Furnishings
Author:
Donald Weston
Target Audience:
Mr. Roger Powell, Sales Manager
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Note:
Year
Contextual description:
A manual outlining the usage of Adobe Photoshop, including various editing tools, file handling, and image manipulation techniques.
Note:
Year
Year:
2023
Region / City:
Oradea
Subject:
Technical guidelines for article formatting
Document type:
Instructional template
Institution:
Universitatea din Oradea
Authors:
Firstname1 LASTNAME1, Firstname2 LASTNAME2, Firstname3 LASTNAME3, Firstname4 LASTNAME4, Firstname5 LASTNAME5
Target Audience:
Authors submitting articles to the journal
Effective period:
Ongoing
Approval date:
Not specified
Modification date:
Not specified
Note:
Year