№ files_lp_4_process_3_116071
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This document is an official correspondence assessing the Regulation Impact Statement for the legalisation of mitochondrial donation in Australia, addressing the adequacy of the regulatory analysis and its alignment with government requirements.
Year:
2021
Region / City:
Australia
Subject:
Regulation Impact Statement
Document Type:
Official Correspondence
Organization / Institution:
Department of Health
Author:
Jason Lange
Target Audience:
Government officials, policy makers
Period of Validity:
Indefinite
Approval Date:
6 April 2021
Date of Last Change:
6 April 2021
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Year:
2015
Region / City:
Australia
Topic:
Regulation, Over-the-Counter Derivatives, Central Clearing
Document Type:
Official Correspondence
Organization:
Office of Best Practice Regulation, The Treasury
Author:
Jason McNamara
Target Audience:
Government officials, regulatory bodies
Period of Validity:
N/A
Approval Date:
August 2015
Date of Amendments:
N/A
Reference:
20855
Telephone:
6271 6270
e-mail:
[email protected]
Note:
Mr Robert Raether
Date:
25 January 2017
Document Type:
Regulation Impact Statement
Subject:
Diverted Profits Tax
Author:
Chris Toyne
Target Audience:
Decision Makers in Government
Period of Action:
Until final decision
Approval Date:
25 January 2017
Amendment Date:
N/A
Description:
A formal communication providing feedback on a Regulation Impact Statement related to a diverted profits tax.
Year:
2020
Region / City:
Australia
Subject:
Industrial Relations, Regulatory Reform
Document Type:
Regulation Impact Statement
Institution:
Attorney-General’s Department, Office of Best Practice Regulation
Author:
Jason Lange
Recipient:
Mr Martin Hehir, Deputy Secretary, Industrial Relations Group
Date Received:
1 December 2020
Date Issued:
2 December 2020
Reference Number:
42818
Contact Information:
Telephone 6271 6270, e-mail [email protected]
Purpose:
Assessment and certification of the RIS for Greenfields Agreements reform
Year:
2021
Region / City:
Australia
Theme:
Regulation Impact Statement, Governance, Charities
Document Type:
Official Correspondence
Author:
Jason Lange
Target Audience:
Deputy Secretary, Revenue Group, The Treasury
Decision Period:
May 2021
Date of Approval:
18 May 2021
Date of Changes:
N/A
Year:
2017
Month:
September
Country:
Australia
City / Region:
Barton ACT
Document Type:
Official correspondence and regulatory review summary
Subject:
Disability Employment Services Program regulation impact assessment
Reference Number:
20623
Institution:
Department of the Prime Minister and Cabinet
Office:
Office of Best Practice Regulation (OBPR)
Sender:
Michael Lye
Recipient:
Mr Wayne Poels
Recipient Position:
Executive Director, Office of Best Practice Regulation
Program:
Disability Employment Services (DES) Program
Related Document:
Regulation Impact Statement (RIS)
Purpose:
Submission of revised RIS for final second-pass review
Key Sections Referenced:
Background; Regulatory Benefit Analysis; Transition, Implementation and Evaluation
Stakeholders Mentioned:
DES providers and participants
Regulatory Framework:
Regulatory Burden Measurement framework
Year:
2024
Region / city:
Global
Topic:
Mitochondrial genetics, gene editing technologies, therapeutic potential
Document type:
Scientific article
Institution:
Not specified
Author:
Gizem INAL
Target audience:
Researchers, clinicians, and medical professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Authors:
Noemi Pasini; Marta Bassitta; Joana F. Ferragut; Maria Teresa Farriols; Natalia Petit-Marty; Francesc Ordinas; Sergio Ramírez-Amaro; Antònia Picornell
Corresponding author:
Sergio Ramírez-Amaro ([email protected]
Note:
)
Affiliations:
Universitat de les Illes Balears; Instituto Español de Oceanografía, Centre Oceanogràfic de les Balears; Institute of Marine Research (IIM-CSIC)
Geographical area:
Menorca Channel, Western Mediterranean Sea
Year of FPZ establishment analyzed:
2016
Subject:
Genetic diversity and fisheries conservation
Keywords:
Nucleotide diversity; COI; Coalescent simulations; Fisheries resources; Protected areas; Mediterranean Sea
Type of document:
Scientific research article
Study focus:
Assessment of mitochondrial COI genetic diversity in exploited marine species inside and outside a Fisheries Protection Zone
Methodology:
Mitochondrial DNA analysis and coalescent simulations
Species scope:
Four exploited marine species
Data sources:
MEDITS and CANAL surveys; Vessel Monitoring System (VMS) data
Year:
Not specified
Region / Country:
China
City:
Shenzhen
Field:
Oncology; Molecular Biology; Bioinformatics
Research Topic:
Nasopharyngeal carcinoma prognosis and gene expression analysis
Document Type:
Scientific research article
Institutions:
Shenzhen University General Hospital; Shenzhen Hospital of Southern Medical University
Departments:
Department of Otolaryngology Head and Neck Surgery; Department of Urology; Department of Anesthesiology
Authors:
Ping Li; Xin Xu; Xueyu Zhang; Huifen Xie; Cuirong Xiao; Yinggui Yang
Corresponding Author:
Yinggui Yang
Ethics Approval:
Ethics Committee of Affiliated Shenzhen Hospital of Southern Medical University
Methodology:
Transcriptomic data analysis; univariate Cox regression; risk model construction; nomogram; gene set enrichment analysis; immune infiltration analysis; drug sensitivity analysis
Key Genes Identified:
ARHGAP4; MEIS1; XCR1
Disease Focus:
Nasopharyngeal carcinoma
Associated Factors:
Epstein-Barr virus infection; mitochondrial dynamics
Data Source:
Public biological databases
Research Objective:
Identification of prognostic genes and development of a predictive risk model for nasopharyngeal carcinoma
Keywords:
Nasopharyngeal carcinoma; Prognostic genes; Risk model; Epstein-Barr virus
Year:
2024
Region / city:
Global
Subject:
Radiotherapy, Cancer Research
Document type:
Research article
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, Oncology professionals
Period of validity:
N/A
Approval date:
Not specified
Modification date:
Not specified
Year:
2006
Field:
Molecular Biology
Document type:
Research Article
Authors:
Paulina Wegrzyn, Stephen J Yarwood, Nathalie Fiegler, et al.
Organ / Institution:
Not specified
Target audience:
Researchers in molecular biology and biochemistry
Experimental model:
HepG2 cells, primary rat hepatocytes
Key molecules:
Mimitin, IL-1, IL-6
Methodology:
Gene expression analysis, luciferase reporter assay
Findings:
Cytokines IL-1 and IL-6 upregulate mimitin expression at transcriptional level
Year:
Not specified
Region / Country:
Not specified
Subject:
Mitochondrial genome sequencing and genetic diagnostics
Document Type:
Medical necessity letter template
Organization:
Not specified
Author:
Not specified
Target Audience:
Healthcare providers and insurance reviewers
Clinical Context:
Suspected mitochondrial disease
Purpose:
Justification for genetic testing based on clinical and family history
Medical Focus:
Genetic testing, mitochondrial disorders, diagnostic strategy
Referenced Guidelines:
Mitochondrial Medicine Society (2015), United Kingdom best practice guidelines (2023)
Testing Method:
Next-generation sequencing, mitochondrial genome sequencing
Evidence Base:
Peer-reviewed scientific literature and clinical guidelines
Patient Information:
Clinical findings, family history, prior testing results
Intended Outcome:
Diagnostic clarification and guidance for clinical management
Year:
2026
Region / City:
Liverpool, United Kingdom; Beerse, Belgium; Spring House, PA, USA; Cambridge, United Kingdom
Subject:
Drug-induced liver injury; Mitochondrial toxicity; Hepatic cell models
Document type:
Research article
Institution / Organization:
MRC Centre for Drug Safety Science, University of Liverpool; Janssen Research and Development; AstraZeneca
Authors:
Laleh Kamalian, Oisin Douglas, Carol Jolly, Jan Snoeys, Damir Simic, Mario Monshouwer, Dominic P. Williams, B. Kevin Park, Amy E. Chadwick
Corresponding author:
Laleh Kamalian
Keywords:
mitochondria, HepaRG, HepG2, seahorse respirometry, bioenergetic phenotype, drug-induced liver injury
Methodology:
In vitro cell line study, Seahorse respirometry, acute metabolic modification assay, bioenergetic phenotyping
Main findings:
HepaRG cells display lower basal metabolic activity than HepG2 but reliably detect mitochondrial toxicity; compounds classified as inhibitors or uncouplers of electron transport chain
Cell lines:
HepaRG, HepG2
Experimental period:
2026
Publication type:
Peer-reviewed scientific study
Language:
English