№ files_lp_4_process_3_126684
File format: docx Character count: 57507 File size: 864 KB
Year: 2026
Region / City: Liverpool, United Kingdom; Beerse, Belgium; Spring House, PA, USA; Cambridge, United Kingdom
Subject: Drug-induced liver injury; Mitochondrial toxicity; Hepatic cell models
Document type: Research article
Institution / Organization: MRC Centre for Drug Safety Science, University of Liverpool; Janssen Research and Development; AstraZeneca
Authors: Laleh Kamalian, Oisin Douglas, Carol Jolly, Jan Snoeys, Damir Simic, Mario Monshouwer, Dominic P. Williams, B. Kevin Park, Amy E. Chadwick
Corresponding author: Laleh Kamalian
Keywords: mitochondria, HepaRG, HepG2, seahorse respirometry, bioenergetic phenotype, drug-induced liver injury
Methodology: In vitro cell line study, Seahorse respirometry, acute metabolic modification assay, bioenergetic phenotyping
Main findings: HepaRG cells display lower basal metabolic activity than HepG2 but reliably detect mitochondrial toxicity; compounds classified as inhibitors or uncouplers of electron transport chain
Cell lines: HepaRG, HepG2
Experimental period: 2026
Publication type: Peer-reviewed scientific study
Language: English
Price: 8 / 10 USD
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Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention
Year: 2023
Region / City: Liverpool, UK
Theme: Bioenergetics, Cardiovascular Health
Document Type: Research Article
Organization / Institution: University of Liverpool
Author: MINGMING YANG, AMY E. CHADWICK, CAROLINE DART, TOMOKO KAMISHIMA, JOHN M. QUAYLE
Target Audience: Researchers, Academics, Cardiovascular Health Professionals
Period of Validity: N/A
Date of Approval: N/A
Date of Modifications: N/A
Metabolomic Profiling of Chronic versus Acute Drug-Induced Liver Injury
Year: 2021
Region / City: China
Topic: Metabolomic Profiling, Drug-Induced Liver Injury
Document Type: Research Article
Organization: The Fifth Medical Center of PLA General Hospital, Liver Diseases Center of General Hospital of Eastern Theater Command, Capital Medical University, Tianjin University of Traditional Chinese Medicine, Beijing Institute of Radiation Medicine
Authors: Jia-bo Wang, Zhuo Shi, Lu-ge Wei, Ang Huang, Xing-ran Zhai, Ming Niu, Jing Xu, Jing Jing, Ting-ting He, Yuan Gao, Zhi-tao Ma, Xu Zhao, Jun-xing Hou, Yu-ming Guo, Zhao-fang Bai, Man Gong, Yue-cheng Yu, Zheng-sheng Zou, Xiao-he Xiao
Target Audience: Researchers, Medical professionals, and Healthcare providers
Duration: Ongoing (Follow-up visits over 12 months)
Approval Date: 2021
Date of Changes: Not specified
Dissecting the molecular pathophysiology of drug-induced liver injury
Year: 2018
Journal: World Journal of Gastroenterology
Manuscript type: Review
Authors: Hui Ye, Leonard J Nelson, Manuel Gómez del Moral, Eduardo Martínez-Naves, Francisco Javier Cubero
Affiliations: Department of Immunology, Complutense University School of Medicine, Madrid, Spain; 12 de Octubre Health Research Institute (imas12), Madrid, Spain; Institute for Bioengineering (IBioE), Human Tissue Engineering, University of Edinburgh, UK; Department of Cell Biology, Complutense University School of Medicine, Madrid, Spain
Funding: Spanish Ministerio de Economía y Competitividad (MINECO) RyC2014-15242, SAF2016-78711; Chinese Scholarship Council
Conflict of interest: None declared
Open-Access: Creative Commons Attribution Non Commercial (CC BY-NC 4.0)
Correspondence: Francisco Javier Cubero, [email protected]
Received: January 27, 2018
Peer-review started: January 28, 2018
First decision: February 10, 2018
Revised: February 16, 2018
Accepted: February 26, 2018
Published online: 2018
Keywords: Drug-induced liver injury, Cell death, Signaling pathways, Acetaminophen, Reactive oxygen species
Abstract summary: Review article analyzing molecular pathways and immune mechanisms involved in drug-induced liver injury, including intrinsic and idiosyncratic hepatotoxicity.
Control Compounds for Preclinical Drug-Induced Liver Injury Assessment: Consensus-driven systematic review by the ProEuroDILI Network
Year: 2023
Region / City: Europe (Spain, Portugal, Slovenia, United Kingdom, Australia)
Topic: Drug-induced liver injury, preclinical assessment
Document Type: Systematic review
Institution / Organization: ProEuroDILI Network, multiple universities and research institutes
Authors: Antonio Segovia-Zafra, Marina Villanueva-Paz, Ana Sofia Serras, Gonzalo Matilla-Cabello, Ana Bodoque-García, Daniel Di Zeo-Sánchez, Hao Niu, Ismael Álvarez-Álvarez, Laura Sanz-Villanueva, Sergej Godec, Irina Milisav, Pierre Bagnaninchi, Raúl Jesús Andrade, María Isabel Lucena, José Carlos Fernández-Checa, Francisco Javier Cubero, Joana Paiva Miranda, Leonard Nelson
Target Audience: Researchers and clinicians in pharmacology and hepatology
Data Type: In vitro human models, cellular and non-cellular models
Period Covered: Preclinical studies up to 2023
Corresponding Authors: María Isabel Lucena, José Carlos Fernández-Checa
Supplementary Material: Human hepatocyte cultures, liver microsomes, liver vesicles, 2D and 3D model systems
Topics: HepaRG Bioenergetic Drug-Induced