№ files_lp_4_process_3_080493
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Study on the modulation of mitochondrial protein mimitin expression by proinflammatory cytokines in cell cultures and its regulatory mechanisms.
Year: 2006
Field: Molecular Biology
Document type: Research Article
Authors: Paulina Wegrzyn, Stephen J Yarwood, Nathalie Fiegler, et al.
Organ / Institution: Not specified
Target audience: Researchers in molecular biology and biochemistry
Experimental model: HepG2 cells, primary rat hepatocytes
Key molecules: Mimitin, IL-1, IL-6
Methodology: Gene expression analysis, luciferase reporter assay
Findings: Cytokines IL-1 and IL-6 upregulate mimitin expression at transcriptional level
Price: 8 / 10 USD
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Mitochondrial Genome Editing: Innovations and Therapeutic Potential
Year: 2024
Region / city: Global
Topic: Mitochondrial genetics, gene editing technologies, therapeutic potential
Document type: Scientific article
Institution: Not specified
Author: Gizem INAL
Target audience: Researchers, clinicians, and medical professionals
Period of validity: Not specified
Approval date: Not specified
Date of changes: Not specified
Genetic diversity in mitochondrial DNA reveals the effect of a Fisheries Protection Zone on exploited marine species in the Menorca Channel (Western Mediterranean)
Authors: Noemi Pasini; Marta Bassitta; Joana F. Ferragut; Maria Teresa Farriols; Natalia Petit-Marty; Francesc Ordinas; Sergio Ramírez-Amaro; Antònia Picornell
Corresponding author: Sergio Ramírez-Amaro ([email protected]
Note: )
Affiliations: Universitat de les Illes Balears; Instituto Español de Oceanografía, Centre Oceanogràfic de les Balears; Institute of Marine Research (IIM-CSIC)
Geographical area: Menorca Channel, Western Mediterranean Sea
Year of FPZ establishment analyzed: 2016
Subject: Genetic diversity and fisheries conservation
Keywords: Nucleotide diversity; COI; Coalescent simulations; Fisheries resources; Protected areas; Mediterranean Sea
Type of document: Scientific research article
Study focus: Assessment of mitochondrial COI genetic diversity in exploited marine species inside and outside a Fisheries Protection Zone
Methodology: Mitochondrial DNA analysis and coalescent simulations
Species scope: Four exploited marine species
Data sources: MEDITS and CANAL surveys; Vessel Monitoring System (VMS) data
Transcriptomic Analysis of Epstein-Barr Virus and Mitochondrial Dynamics-Related Genes in Nasopharyngeal Carcinoma Prognosis
Year: Not specified
Region / Country: China
City: Shenzhen
Field: Oncology; Molecular Biology; Bioinformatics
Research Topic: Nasopharyngeal carcinoma prognosis and gene expression analysis
Document Type: Scientific research article
Institutions: Shenzhen University General Hospital; Shenzhen Hospital of Southern Medical University
Departments: Department of Otolaryngology Head and Neck Surgery; Department of Urology; Department of Anesthesiology
Authors: Ping Li; Xin Xu; Xueyu Zhang; Huifen Xie; Cuirong Xiao; Yinggui Yang
Corresponding Author: Yinggui Yang
Ethics Approval: Ethics Committee of Affiliated Shenzhen Hospital of Southern Medical University
Methodology: Transcriptomic data analysis; univariate Cox regression; risk model construction; nomogram; gene set enrichment analysis; immune infiltration analysis; drug sensitivity analysis
Key Genes Identified: ARHGAP4; MEIS1; XCR1
Disease Focus: Nasopharyngeal carcinoma
Associated Factors: Epstein-Barr virus infection; mitochondrial dynamics
Data Source: Public biological databases
Research Objective: Identification of prognostic genes and development of a predictive risk model for nasopharyngeal carcinoma
Keywords: Nasopharyngeal carcinoma; Prognostic genes; Risk model; Epstein-Barr virus
The Possible Role of Mitochondrial ATM, CDK-1, and RAN Expression in the Radioresistance of Human Lung Adenocarcinoma A549 Cells
Year: 2024
Region / city: Global
Subject: Radiotherapy, Cancer Research
Document type: Research article
Institution: Not specified
Author: Not specified
Target audience: Researchers, Oncology professionals
Period of validity: N/A
Approval date: Not specified
Modification date: Not specified
Letter of Medical Necessity for Mitochondrial Genome Sequencing
Year: Not specified
Region / Country: Not specified
Subject: Mitochondrial genome sequencing and genetic diagnostics
Document Type: Medical necessity letter template
Organization: Not specified
Author: Not specified
Target Audience: Healthcare providers and insurance reviewers
Clinical Context: Suspected mitochondrial disease
Purpose: Justification for genetic testing based on clinical and family history
Medical Focus: Genetic testing, mitochondrial disorders, diagnostic strategy
Referenced Guidelines: Mitochondrial Medicine Society (2015), United Kingdom best practice guidelines (2023)
Testing Method: Next-generation sequencing, mitochondrial genome sequencing
Evidence Base: Peer-reviewed scientific literature and clinical guidelines
Patient Information: Clinical findings, family history, prior testing results
Intended Outcome: Diagnostic clarification and guidance for clinical management
Regulation Impact Statement – Second-Pass Final Assessment – Legalisation of mitochondrial donation in Australia
Year: 2021
Region / City: Australia
Subject: Regulation Impact Statement
Document Type: Official Correspondence
Organization / Institution: Department of Health
Author: Jason Lange
Target Audience: Government officials, policy makers
Period of Validity: Indefinite
Approval Date: 6 April 2021
Date of Last Change: 6 April 2021
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Year: 2026
Region / City: Liverpool, United Kingdom; Beerse, Belgium; Spring House, PA, USA; Cambridge, United Kingdom
Subject: Drug-induced liver injury; Mitochondrial toxicity; Hepatic cell models
Document type: Research article
Institution / Organization: MRC Centre for Drug Safety Science, University of Liverpool; Janssen Research and Development; AstraZeneca
Authors: Laleh Kamalian, Oisin Douglas, Carol Jolly, Jan Snoeys, Damir Simic, Mario Monshouwer, Dominic P. Williams, B. Kevin Park, Amy E. Chadwick
Corresponding author: Laleh Kamalian
Keywords: mitochondria, HepaRG, HepG2, seahorse respirometry, bioenergetic phenotype, drug-induced liver injury
Methodology: In vitro cell line study, Seahorse respirometry, acute metabolic modification assay, bioenergetic phenotyping
Main findings: HepaRG cells display lower basal metabolic activity than HepG2 but reliably detect mitochondrial toxicity; compounds classified as inhibitors or uncouplers of electron transport chain
Cell lines: HepaRG, HepG2
Experimental period: 2026
Publication type: Peer-reviewed scientific study
Language: English
Topics: Mimitin cytokine-regulated Mitochondrial