№ files_lp_4_process_3_112801
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File size: 32 KB
Formal medical document outlining clinical justification and background evidence for requesting mitochondrial genome sequencing in patients with suspected mitochondrial disorders.
Year:
Not specified
Region / Country:
Not specified
Subject:
Mitochondrial genome sequencing and genetic diagnostics
Document Type:
Medical necessity letter template
Organization:
Not specified
Author:
Not specified
Target Audience:
Healthcare providers and insurance reviewers
Clinical Context:
Suspected mitochondrial disease
Purpose:
Justification for genetic testing based on clinical and family history
Medical Focus:
Genetic testing, mitochondrial disorders, diagnostic strategy
Referenced Guidelines:
Mitochondrial Medicine Society (2015), United Kingdom best practice guidelines (2023)
Testing Method:
Next-generation sequencing, mitochondrial genome sequencing
Evidence Base:
Peer-reviewed scientific literature and clinical guidelines
Patient Information:
Clinical findings, family history, prior testing results
Intended Outcome:
Diagnostic clarification and guidance for clinical management
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2024
Region / city:
Global
Topic:
Mitochondrial genetics, gene editing technologies, therapeutic potential
Document type:
Scientific article
Institution:
Not specified
Author:
Gizem INAL
Target audience:
Researchers, clinicians, and medical professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Authors:
Noemi Pasini; Marta Bassitta; Joana F. Ferragut; Maria Teresa Farriols; Natalia Petit-Marty; Francesc Ordinas; Sergio Ramírez-Amaro; Antònia Picornell
Corresponding author:
Sergio Ramírez-Amaro ([email protected]
Note:
)
Affiliations:
Universitat de les Illes Balears; Instituto Español de Oceanografía, Centre Oceanogràfic de les Balears; Institute of Marine Research (IIM-CSIC)
Geographical area:
Menorca Channel, Western Mediterranean Sea
Year of FPZ establishment analyzed:
2016
Subject:
Genetic diversity and fisheries conservation
Keywords:
Nucleotide diversity; COI; Coalescent simulations; Fisheries resources; Protected areas; Mediterranean Sea
Type of document:
Scientific research article
Study focus:
Assessment of mitochondrial COI genetic diversity in exploited marine species inside and outside a Fisheries Protection Zone
Methodology:
Mitochondrial DNA analysis and coalescent simulations
Species scope:
Four exploited marine species
Data sources:
MEDITS and CANAL surveys; Vessel Monitoring System (VMS) data
Year:
Not specified
Region / Country:
China
City:
Shenzhen
Field:
Oncology; Molecular Biology; Bioinformatics
Research Topic:
Nasopharyngeal carcinoma prognosis and gene expression analysis
Document Type:
Scientific research article
Institutions:
Shenzhen University General Hospital; Shenzhen Hospital of Southern Medical University
Departments:
Department of Otolaryngology Head and Neck Surgery; Department of Urology; Department of Anesthesiology
Authors:
Ping Li; Xin Xu; Xueyu Zhang; Huifen Xie; Cuirong Xiao; Yinggui Yang
Corresponding Author:
Yinggui Yang
Ethics Approval:
Ethics Committee of Affiliated Shenzhen Hospital of Southern Medical University
Methodology:
Transcriptomic data analysis; univariate Cox regression; risk model construction; nomogram; gene set enrichment analysis; immune infiltration analysis; drug sensitivity analysis
Key Genes Identified:
ARHGAP4; MEIS1; XCR1
Disease Focus:
Nasopharyngeal carcinoma
Associated Factors:
Epstein-Barr virus infection; mitochondrial dynamics
Data Source:
Public biological databases
Research Objective:
Identification of prognostic genes and development of a predictive risk model for nasopharyngeal carcinoma
Keywords:
Nasopharyngeal carcinoma; Prognostic genes; Risk model; Epstein-Barr virus
Year:
2024
Region / city:
Global
Subject:
Radiotherapy, Cancer Research
Document type:
Research article
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, Oncology professionals
Period of validity:
N/A
Approval date:
Not specified
Modification date:
Not specified
Year:
2006
Field:
Molecular Biology
Document type:
Research Article
Authors:
Paulina Wegrzyn, Stephen J Yarwood, Nathalie Fiegler, et al.
Organ / Institution:
Not specified
Target audience:
Researchers in molecular biology and biochemistry
Experimental model:
HepG2 cells, primary rat hepatocytes
Key molecules:
Mimitin, IL-1, IL-6
Methodology:
Gene expression analysis, luciferase reporter assay
Findings:
Cytokines IL-1 and IL-6 upregulate mimitin expression at transcriptional level
Year:
2021
Region / City:
Australia
Subject:
Regulation Impact Statement
Document Type:
Official Correspondence
Organization / Institution:
Department of Health
Author:
Jason Lange
Target Audience:
Government officials, policy makers
Period of Validity:
Indefinite
Approval Date:
6 April 2021
Date of Last Change:
6 April 2021
Year:
2026
Region / City:
Liverpool, United Kingdom; Beerse, Belgium; Spring House, PA, USA; Cambridge, United Kingdom
Subject:
Drug-induced liver injury; Mitochondrial toxicity; Hepatic cell models
Document type:
Research article
Institution / Organization:
MRC Centre for Drug Safety Science, University of Liverpool; Janssen Research and Development; AstraZeneca
Authors:
Laleh Kamalian, Oisin Douglas, Carol Jolly, Jan Snoeys, Damir Simic, Mario Monshouwer, Dominic P. Williams, B. Kevin Park, Amy E. Chadwick
Corresponding author:
Laleh Kamalian
Keywords:
mitochondria, HepaRG, HepG2, seahorse respirometry, bioenergetic phenotype, drug-induced liver injury
Methodology:
In vitro cell line study, Seahorse respirometry, acute metabolic modification assay, bioenergetic phenotyping
Main findings:
HepaRG cells display lower basal metabolic activity than HepG2 but reliably detect mitochondrial toxicity; compounds classified as inhibitors or uncouplers of electron transport chain
Cell lines:
HepaRG, HepG2
Experimental period:
2026
Publication type:
Peer-reviewed scientific study
Language:
English
Year:
2026
Region / City:
Virginia, USA
Topic:
Genome Annotation
Document Type:
Cover Sheet
Organization / Institution:
Virginia Western Community College
Author:
Heather Lindberg
Target Audience:
QC reviewers, students
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / city:
Montclair, NJ
Subject:
Genomics, Phage Research
Document Type:
Submission Form
Institution:
Montclair State University
Author:
Kirsten Monsen-Collar
Target Audience:
Researchers, QC reviewers, Phage annotation teams
Period of Action:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2023
Region / City:
Not specified
Theme:
Genome annotation, Actinobacteriophage
Document Type:
Cover Sheet
Organization / Institution:
CCSNH-NHTI
Author:
Joseph Christiansen, Beth Wilkes
Target Audience:
QC reviewers, annotators
Period of Validity:
Not specified
Approval Date:
Not specified
Amendment Date:
Not specified
Year:
2021
Region / City:
United States
Topic:
Phage genome annotation
Document type:
Submission cover sheet
Organization:
Nova Southeastern University
Author:
Ashley Janke
Target Audience:
QC reviewers, phage researchers
Date of submission:
Not specified
Date of modification:
Not specified
Year:
N/A
Region / City:
N/A
Theme:
Manuscript formatting guidelines
Document type:
Template
Organization / Institution:
N/A
Author:
N/A
Target audience:
Researchers and authors submitting manuscripts
Period of validity:
N/A
Approval date:
N/A
Date of amendments:
N/A
Year:
Not specified
Region / City:
Not specified
Subject:
Phage genome annotation
Document Type:
Cover sheet
Organization / Institution:
Virginia Western Community College
Author:
Heather Lindberg
Target Audience:
QC reviewer
Period of validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
Coastal Georgia
Topic:
Phage Genome Annotation
Document Type:
Cover Sheet
Organization / Institution:
College of Coastal Georgia
Author:
Holly Nance
Target Audience:
QC reviewers, researchers in genomics
Effective Period:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
Annually
Region / City:
United States (CDC)
Topic:
Healthcare-Associated Infections, Antimicrobial Resistance
Document Type:
Report
Organ / Institution:
Centers for Disease Control and Prevention (CDC)
Author:
Not specified
Target Audience:
Funded laboratories, public health officials
Period of Validity:
Annual
Approval Date:
Not specified
Date of Changes:
Not specified
Phage Name:
Schism
Author:
Justin Anderson
Institution:
Southeastern Louisiana University
Email:
[email protected]
Additional Emails:
[email protected]
Document Type:
Genome annotation submission cover sheet
Target Audience:
QC reviewers and instructors
Content:
Description of annotation process, gene issues, and validation checks
Gene Highlights:
Gene at stop 31170, Gene at stop 35089
File Type Submitted:
Spreadsheet
Protocols Followed:
tRNA annotation, frameshift annotation, Feature Table documentation
Validation Checklist:
DNA Master validation, LocusTag sequence, Feature_Type correctness, Product field verification
Year:
2023
Region / City:
Amherst, Massachusetts
Topic:
Genome Annotation
Document Type:
Cover Sheet
Organization / Institution:
UMass Amherst
Author:
Jessica Rocheleau
Target Audience:
QC reviewers
Period of Validity:
N/A
Date of Approval:
N/A
Date of Changes:
N/A
Phage name:
Sorpresa
Document type:
Genome annotation submission cover sheet
Scientific field:
Actinobacteriophage genomics
Institution:
Brigham Young University
Author:
Jayden S. Longhurst
Contributor roles:
Student annotator
Quality control context:
SEA-PHAGES genome annotation review
Genes highlighted for review:
ORF 90, ORF 68
Genome features discussed:
Orphams, transposase, synteny rearrangement
Annotation tools referenced:
DNA Master, PECAAN, Aragorn, BLAST, PhagesDB
Submission purpose:
Quality control review of genome annotation
Source type:
Academic course-related scientific documentation
Note:
Year
Author:
Tamarah Adair