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The document outlines a national protocol for administering COVID-19 mRNA vaccines to eligible adults in Northern Ireland under the guidance of trained healthcare professionals.
Year:
2025
Region / City:
Northern Ireland
Topic:
COVID-19 vaccination, mRNA vaccines
Document Type:
Protocol
Organization / Institution:
Strategic Planning and Performance Group (SPPG), Public Health Agency (PHA)
Author:
Dr. Louise Herron, Mrs. Deirdre Ward, Mrs. Kathryn Turner
Target Audience:
Healthcare professionals administering COVID-19 mRNA vaccines
Period of Validity:
3 April 2025 to 30 June 2025
Approval Date:
3 April 2025
Note:
Change History
Version 1.0:
New national protocol for COVID-19 vaccines (adults) - 5 April 2024
Version 2.0:
Updated to reflect change in vaccine antigenic content - 16 September 2024
Version 3.0:
Updated eligibility criteria for Spring 2025 - 6 March 2025
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Year:
2026
Region / City:
Not specified
Topic:
BDNF expression analysis
Document Type:
Research data
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers in molecular biology and neuroscience
Period of validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2025
Region / city:
United Kingdom
Subject:
COVID-19 vaccination
Document type:
Protocol
Institution:
UK Health Security Agency (UKHSA)
Author:
UK Health Security Agency (UKHSA)
Target audience:
Healthcare providers involved in COVID-19 vaccination
Period of validity:
1 October 2025 – 31 January 2026
Approval date:
12 September 2025
Note:
Revision history
Year:
Not specified
Species:
Piglet
Tissue:
Hippocampus
Gene:
BDNF
Reference gene:
RO
Method:
RT-qPCR
Data type:
Raw quantitative PCR data
Experimental groups:
Control, 18 µg/kg, 46 µg/kg
Measurements:
CT, ΔCT, ΔΔCT, 2^-ΔΔCT, 2^-ΔCT
Statistical parameters:
Average, STDEV
Sample identifiers:
Sample 1–Sample 50
Document type:
Supplementary data table
Reference no:
COVID-19 mRNA vaccine (5 years and over) PGD
Version no:
v3.0
Valid from:
1 October 2025
Expiry date:
31 January 2026
Developed by:
UKHSA
Healthcare practitioners:
Registered healthcare practitioners identified in section 3
Amendment history:
Updated in versions v1.0, v2.0, and v3.0
Target group:
Eligible individuals aged 5 years and over
Immunisation programme:
National COVID-19 vaccination programme
Eligibility criteria:
Based on age and health conditions
Training requirements:
Compliance with national vaccination training standards
Review panel:
UKHSA Immunisations PGD Expert Panel
Expert authors:
Pharmacist Christina Wilson, Dr Alex Allen, Nurse David Green
NHS England responsibility:
Governance and authorisation
Period of retention:
25 years for NHS England, 8–25 years for providers
NHS England governance:
NHS England accepts responsibility for PGD governance
Year:
2025
Region / city:
United Kingdom
Subject:
COVID-19 vaccination
Document type:
Protocol
Organization / institution:
UK Health Security Agency (UKHSA)
Author:
UK Health Security Agency (UKHSA)
Target audience:
Healthcare professionals involved in COVID-19 vaccination
Effective period:
From 1 October 2025 to 31 January 2026
Approval date:
12 September 2025
Note:
Amendment history
v1.0:
6 September 2024
v2.0:
18 February 2025
v3.0:
29 August 2025
Description:
Protocol for the administration of COVID-19 mRNA vaccine to individuals aged 5 years and over, detailing eligibility, vaccine preparation, and staff requirements.
Note:
Year
Authors:
Cassandra M. Juran; Justina Zvirblyte; Yasaman Sharazi; Angela Kubik; Margareth Cheng-Campbell; Elizabeth Blaber; Eduardo Almeida
Affiliations:
Blue Marble Space Institute of Science at NASA Ames Research Center, Mountain View, CA, USA; Vilnius University, Vilnius, Lithuania; Rensselaer Polytechnic Institute, Troy, NY, USA; NASA Ames Research Center, Moffett Field, CA, USA
Research Field:
Stem cell biology; Bone regeneration; Mechanobiology; Space biology
Key Gene:
CDKN1A (Cdkn1a)
Experimental Models:
Wildtype and Cdkn1a-null mice
Methods:
Single-cell mRNA sequencing; in-vitro mechanical stretch; hindlimb unloading; running wheel and treadmill loading; spaceflight microgravity exposure
Space Mission:
Rodent Research-10 aboard the International Space Station
Duration of Spaceflight:
30 days
Biological Material:
Femur bone marrow; mesenchymal osteoprogenitors; osteoblast lineage cells
Type of Document:
Scientific research article
Institutional Context:
NASA-affiliated and academic biomedical research collaboration
Year:
2023
Region / City:
Not specified
Topic:
m6A methylation, NLRP3 mRNA
Document Type:
Research Supplementary Table
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers in molecular biology and genetics
Period of Action:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2026
Region / City:
International
Subject:
mRNA synthesis and customization
Document Type:
Quotation Request Form
Organization:
Blue Heron Biotech
Target Audience:
Researchers and biotech companies
Required Materials:
DNA template ≥ 20 µg
Template Options:
Circular plasmid or PCR product
Promoter Options:
T7 promoter included or to be added
UTR Options:
5’ and 3’ UTR sequences provided or selected
Modifications:
Pseudouridine, N1-me-pseudouridine, 5-methoxyuridine, 5-me-Cytidine
Purification Methods:
Silica membrane-based or alternative
mRNA Scale Options:
100 µg, 150 µg, 200 µg
QC Tests:
Visual appearance, nanodrop concentration, PAGE/agarose integrity, pH, optional capping efficiency, CE-based size and integrity, endotoxin test
Storage Buffer Options:
Nuclease-free water, 1mM Sodium citrate pH 6.4
Authors:
Tony Malmqvist; Karen Anthony; Jean-Marc Gallo
Affiliation:
Department of Clinical Neuroscience, King’s College London, Institute of Psychiatry, London, United Kingdom
Corresponding Author:
Jean-Marc Gallo
Institutional Address:
King’s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Type of Document:
Scientific research article
Field of Study:
Neuroscience; Molecular and Cellular Biology
Research Subject:
Localization and translation of tau mRNA in rat cortical neurons
Biological Material:
Primary rat cortical neurons
Key Methods:
Fluorescence in situ hybridization (FISH); RNA staining; immunocytochemistry
Key Molecules:
Tau mRNA; eukaryotic elongation factor 1A (eEF1A); neurofilament heavy subunit (NF-H)
Geographical Context:
London, United Kingdom
Institutional Context:
King’s College London, Institute of Psychiatry
Language:
English
Year:
2026
Region / Institution:
Not specified
Topic:
Immunology, SARS-CoV-2, Vaccine Response
Document type:
Peer Review
Author:
Stefania P Bjarnarson
Target audience:
Researchers, Immunologists
Study period:
Up to 33 months post mRNA vaccination
Methods:
Analysis of bone marrow plasma cells, healthy adult donors, post-vaccination sampling
Key findings:
Limited presence of SARS-CoV-2-specific long-lived plasma cells in bone marrow after mRNA vaccination or hybrid immunity
Data source:
Bone marrow aspirates, hip joint replacement surgery samples
Limitations:
Small sample size, discrepancies in patient description, consideration of asymptomatic infections
Scientific relevance:
Provides evidence on the longevity of humoral immune response post-vaccination
Concise description:
Peer-reviewed evaluation of a study assessing the presence of SARS-CoV-2-specific long-lived plasma cells in the bone marrow following mRNA vaccination and hybrid immunity, highlighting methodology, key results, and points for revision.
Year:
2016
Region / city:
Not specified
Topic:
Methods
Document type:
Research Methodology
Organization:
Not specified
Author:
Not specified
Target audience:
Researchers in the field of molecular biology
Period of validity:
Not specified
Date of approval:
Not specified
Date of modification:
Not specified
Year:
2021
Region / city:
Australia
Theme:
Medical Research, mRNA Clinical Trials
Document Type:
Grant Application Guidelines
Organization / Institution:
Department of Industry, Science, Energy and Resources
Author:
Department of Industry, Science, Energy and Resources
Target Audience:
Researchers, Institutions, Organizations applying for MRFF grants
Period of Validity:
2021-2022
Approval Date:
December 2021
Amendment Date:
None
Program:
MRFF – 2021 mRNA Clinical Trial Enabling Infrastructure
Eligibility Criteria:
State government partner required, Organization must be incorporated in Australia, Entity type selection
Required Documents:
Financial details, ABN, Program selection
Supported Browsers:
Mozilla Firefox, Google Chrome, Microsoft Edge (Windows), Safari, Google Chrome (Mac)
Description:
Online application form for the MRFF 2021 mRNA Clinical Trial Enabling Infrastructure grant opportunity outlining instructions and eligibility criteria for applicants.
Year:
2016–2021
Field:
Cancer Genomics
Research Topic:
Lung Adenocarcinoma (LUAD) Molecular Subtypes
Document Type:
Supplementary Scientific Notes and Figures
Study Context:
Comparative analysis with Chen et al. 2016 study and related genomic datasets
Data Sources:
TCGA LUAD cohort; CCLE LUAD cell lines; CPTAC LUAD cohort
Analytical Methods:
mRNA expression clustering; GSVA pathway analysis; MutSig2CV mutation analysis; GISTIC2.0 copy number analysis; Cox proportional hazards modeling
Key Molecular Features:
STK11/KRAS co-mutation; MET activation; stem cell gene signature
Subtype Classification:
Five LUAD mRNA expression subtypes (S1–S5)
Comparative Subtypes Referenced:
PP, PI, TRU expression-based subtypes
Genomic Data Types:
DNA copy number; DNA methylation; mRNA expression; miRNA expression; protein expression
Immune Phenotyping Source:
TCGA H&E image–based immune scores
Gene Signature Components:
C6orf62; DNER; NELL2; LATS2; LGR5; PTPRO; LRIG1; PABPC1; NT5E; SET
Referenced Studies:
Chen et al., 2016; Huang et al., 2021; Thorsson et al., 2018
Year:
2025
Region / city:
Global
Topic:
Vaccine Policy, Maternal Health, Group B Streptococcus
Document type:
WHO Guidance
Institution:
World Health Organization (WHO)
Author:
WHO ECVP
Target audience:
Policymakers, Vaccine Developers, Public Health Authorities
Period of validity:
Ongoing
Approval date:
March 11, 2025
Date of changes:
Not specified
Year:
2024
Region / city:
Global
Topic:
COVID-19 Vaccines
Document type:
Report
Author:
World Health Organization (WHO)
Target audience:
Health professionals, regulatory authorities
Approval date:
16 January 2024
Modification date:
N/A
Contextual description:
A report listing COVID-19 vaccines evaluated under the WHO EUL/PQ process, including details on manufacturers, vaccine types, shelf lives, and approval dates.
Year:
2026
Jurisdiction:
Victoria, Australia
Document type:
Report form
Subject:
Vaccine cold chain breach reporting
Issuing authority:
Department of Health, Victorian Government
Program:
Immunisation Program
Applicable vaccines:
Government funded vaccines and immunisation products
Target users:
Immunisation providers
Scope:
Cold chain breach events excluding delivery incidents
Temperature range reference:
+2°C to +8°C
Reporting method:
Email submission to Immunisation Program
Publication date:
January 2026
Publisher:
State of Victoria, Australia
Copyright holder:
Department of Health, Victoria
Note:
Year
Region / City:
Alabama
Theme:
Vaccine management, immunization program
Document Type:
Vaccine management plan
Organization / Institution:
Alabama Department of Public Health (ADPH)
Author:
Alabama Department of Public Health (ADPH)
Target Audience:
VFC providers, immunization staff
Effective Period:
Ongoing
Year:
2024
Region / City:
Victoria, Australia
Topic:
Immunisation
Document Type:
Official Information
Author:
Department of Health, State of Victoria
Target Audience:
Healthcare professionals, parents, and individuals requiring immunisation information
Period of Validity:
Not specified
Approval Date:
August 2024
Date of Changes:
Not specified