№ files_lp_4_process_3_087356
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Supplementary scientific material describing analyses of lung adenocarcinoma mRNA expression subtypes, their concordance with previously reported clusters, associated genomic alterations, immune phenotypes, stem cell signatures, and experimental observations across TCGA, CCLE, and CPTAC datasets.
Year:
2016–2021
Field:
Cancer Genomics
Research Topic:
Lung Adenocarcinoma (LUAD) Molecular Subtypes
Document Type:
Supplementary Scientific Notes and Figures
Study Context:
Comparative analysis with Chen et al. 2016 study and related genomic datasets
Data Sources:
TCGA LUAD cohort; CCLE LUAD cell lines; CPTAC LUAD cohort
Analytical Methods:
mRNA expression clustering; GSVA pathway analysis; MutSig2CV mutation analysis; GISTIC2.0 copy number analysis; Cox proportional hazards modeling
Key Molecular Features:
STK11/KRAS co-mutation; MET activation; stem cell gene signature
Subtype Classification:
Five LUAD mRNA expression subtypes (S1–S5)
Comparative Subtypes Referenced:
PP, PI, TRU expression-based subtypes
Genomic Data Types:
DNA copy number; DNA methylation; mRNA expression; miRNA expression; protein expression
Immune Phenotyping Source:
TCGA H&E image–based immune scores
Gene Signature Components:
C6orf62; DNER; NELL2; LATS2; LGR5; PTPRO; LRIG1; PABPC1; NT5E; SET
Referenced Studies:
Chen et al., 2016; Huang et al., 2021; Thorsson et al., 2018
Price: 8 / 10 USD
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Year:
2026
Region / City:
Not specified
Topic:
Lung cancer morphology and survival analysis
Document Type:
Research Supplement
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, oncologists
Period of Action:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Subject:
Biology
Topic:
Genetic variants and phenotypes
Key concepts:
Mutation, gene transcription, translation, protein synthesis, RNA polymerase binding, amino acid sequence
Curriculum references:
SB3.9B; SB3.10B
Document type:
Lesson plan
Educational level:
Secondary education
Components:
Objectives; Learning outcomes; Quick Quiz; Starters; Exploring activities; Worksheets; Safety guidance; Equipment list
Resources referenced:
ALDS presentation SB3e Genetic variants and phenotypes objectives; ALDS presentation SB3e Quick Quiz; Worksheet SB3e.1; Worksheet SB3e.2; Student Book SB3d Protein synthesis
Assessment methods:
Quick Quiz; Progression questions; Confidence level scoring; Peer checking activity
Practical activities:
Protein modelling with beads; Genetic code transcription and translation exercise
Safety considerations:
Eye protection required; Slip hazard from dropped beads
Year:
2023
Region / City:
Not specified
Topic:
Dendritic phenotyping, RNAi stocks
Document type:
Research data
Organization / Institution:
Not specified
Author:
Not specified
Target audience:
Researchers in neuroscience, specifically in the field of neuronal phenotyping
Validity period:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Document type:
Supplementary tables
Study population:
HIV-positive (n=142) and HIV-negative (n=73) participants
Subgroup analysis:
HIV-negative participants (n=71 with pre-; n=73 with post- measurements)
Measured variables:
CD4 T cell phenotypes, CD8 T cell phenotypes, monocyte phenotypes
Phenotype categories:
Differentiation, Activation Profiles, Inflammation/Exhaustion Profiles, Senescence Profiles
Monocyte subsets:
Classical, Intermediate, Non-Classical
Pulmonary function measures:
FEV1, FVC, FEV1/FVC, DLCO
Statistical methods:
Two-sample t-test; linear regression models with adjustment for HBV infection, HCV infection, smoking pack-years, body-mass index, marijuana use, crack cocaine use, injection drug use, tuberculosis, pneumonia
Data presentation:
Median (IQR); standardized beta coefficients
Reference standards:
NHANES III predicted lung function values
Significance thresholds:
P < 0.05 with Bonferroni correction (P=0.05/112)
Year:
2026
Region / City:
Honolulu, HI, USA; Ann Arbor, MI, USA
Topic:
Hepatocellular carcinoma genetics
Document type:
Research article
Institution:
University of Hawaii Cancer Center; University of Michigan
Authors:
Kumardeep Chaudhary, Olivier B Poirion, Liangqun Lu, Sijia Huang, Travers Ching, Lana X Garmire
Funding:
NIEHS K01ES025434, P20 COBRE GM103457, NICHD R01 HD084633, NLM R01LM012373, Hawaii Community Foundation 14ADVC-64566
Target audience:
Biomedical researchers, oncologists, bioinformaticians
Methods:
Multi-modal meta-analysis, mutation profiling, Kaplan-Meier survival analysis, bipartite graph analysis
Sample size:
1494 HCC samples across 6 cohorts
Key findings:
Associations of consensus driver genes with phenotypes, miR expression, CNV, and overall survival
Supplementary materials:
Figures S1–S8, Table S1, File S1
Document type of source:
Peer-reviewed scientific publication
Year:
2023
Region / City:
Yangling
Subject:
Genomics, Plant Biology, Wheat Breeding
Document Type:
Research Article
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers in Plant Genomics and Breeding
Period of Validity:
Not applicable
Date of Approval:
Not applicable
Date of Changes:
Not applicable
Year:
2015
Region / City:
Pittsburgh, PA, USA
Topic:
Public school construction and procurement
Document Type:
Report
Organization:
Pittsburgh Public Schools – Minority/Women Business Department
Audience:
School administrators, procurement officials, minority and women-owned businesses
Period Covered:
April–June 2015
Contracts Reviewed:
Sealed bid projects for facilities, maintenance, and equipment
EBE Categories:
MBE, WBE, DBE
Total Contract Amounts:
Listed per project
Project Locations:
Various Pittsburgh public schools including Faison K-5, Minadeo PreK-8, Sci Tech, Allderdice, Allegheny, Banksville, Brashear, Dilworth, Fulton, Grandview, Greenfield, Lincoln, Spring Hill, Linden, Obama 6-12
Subcontractor Details:
Race and gender of subcontractors included
Rejections and Rebids:
Noted with financial impact
Approval Dates:
April 23, 2015 – December 31, 2015 (some projects through 2016)
Year:
2011
Region / City:
Wilhelmina Children’s Hospital
Subject:
Juvenile idiopathic arthritis treatment and medication
Document Type:
Research Supplementary Material
Organization / Institution:
Wilhelmina Children’s Hospital
Author:
Not specified
Target Audience:
Medical professionals, researchers
Period of validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2026
Study type:
Neuroimaging research
Subject:
Major depressive disorder with psychomotor subtypes
Methodology:
Group-level functional connectivity analysis, seed-based connectivity, ANOVA, FDR correction
Participants:
107 patients (100 with psychomotor retardation, 7 with agitation)
Brain regions analyzed:
Left and right somatomotor network, anterior and posterior cerebellar network
Control variables:
Age, gender, head motion
Figures:
S1, S2
Data source:
MRI scans
Objective:
Evaluate robustness of functional connectivity findings across psychomotor subtypes and motion artifacts
Year:
2011
Region / City:
Pittsburgh, PA, USA
Document Type:
Report
Department / Organization:
Pittsburgh Public Schools – Minority/Women Business Department
Subject:
Construction and consulting contract awards
EBE Categories:
MBE, WBE, DBE
Quarter:
2nd Quarter (April–June)
Total Contract Amount:
$11,614,662
EBE Total:
$3,540,091
Consultant/Contracted Services Total:
$2,010,719
Grand Total EBE Participation:
34%
Data Source:
Sealed bids and consultant contracts
Funding Reference:
ARRA (American Recovery and Reinvestment Act)
Year:
2026
Region / City:
Jinan, Shandong; Beijing, China
Topic:
Pharmacology, Traditional Chinese Medicine, Neuroscience
Document Type:
Research article
Institution:
Shandong University of Traditional Chinese Medicine; Chinese Academy of Traditional Chinese Medicine
Authors:
Xiaoyan Xue, Hongxiu Zhang, Yanting Lu, Jin Pan, Qiancheng Mao, Xing Chang, Shijun Wang, Xiaobin Song, Ke Ma
Correspondence:
Shijun Wang, Xiaobin Song, Ke Ma
Methods:
UHPLC-Q-TOF/MS, HPLC, UPLC-QTOF-MS/MS
Subject:
GABAergic interneurons, antidepressant activity, LBRD formulation
Supplementary Figures:
Total ion chromatogram, HPLC chromatograms, PV and VIP interneuron effects
Supplementary Tables:
Chemical constituents characterization, quality control data
Context:
Experimental study detailing chemical composition of LBRD and its effects on GABAergic interneuron subtypes in a research setting, providing quantitative analysis of active compounds.
Year:
2015
Region / City:
Pittsburgh
Topic:
Minority/Women Business Engagement
Document Type:
Report
Agency / Institution:
Pittsburgh Public Schools
Author:
Pittsburgh Public Schools Minority/Women Business Department
Target Audience:
School District Stakeholders, Contractors, Business Entities
Period of Action:
October – December 2015
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
Global
Topic:
Cancer Research
Document Type:
Scientific Table
Organization / Institution:
dbDEMC
Author:
Not specified
Target Audience:
Researchers, Medical Professionals
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Context:
A detailed compilation of cancer types, subtypes, and corresponding cell line names included in the dbDEMC 3.0 database.