№ lp_1_2_00856
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This guideline outlines best practices for the identification, management, and care of sepsis patients within the Canberra Health Services network.
Year:
2023
Region / City:
Canberra
Theme:
Sepsis management
Document Type:
Guideline
Institution:
Canberra Health Services
Author:
Canberra Health Services Team
Target Audience:
Medical Team members, Registered Nurses and Midwives, Enrolled Nurses, Pharmacists, Allied Health professionals
Period of Validity:
Ongoing
Approval Date:
Not specified
Date of Changes:
Not specified
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Note:
Year
Theme:
Medical procedure
Document Type:
Clinical guideline
Organization / Institution:
Canberra Health Services
Target Audience:
Healthcare professionals at North Canberra Hospital
Year:
2023
Region / City:
Warrington
Topic:
Sepsis Screening
Document Type:
Instructional Guide
Organization / Institution:
Warrington Emergency Department
Author:
Not specified
Target Audience:
Healthcare professionals
Action Period:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2017
Region / City:
Emergency Department
Topic:
Severe Sepsis, Septic Shock, Patient Rescreening
Document Type:
Advisory, Medical Alert
Institution:
UCLA
Author:
Not specified
Target Audience:
Emergency Department Nurses
Action Period:
3/3/17 – proposed changes
Approval Date:
Not specified
Modification Date:
3/24/17
Context:
A guideline for the early identification and rescreening of patients at risk for severe sepsis or septic shock in an emergency department setting, with detailed criteria for triggers and actions.
Year:
2024
Region / City:
Swansea Bay UHB
Subject:
Sepsis Quality Priority
Document Type:
Report
Institution:
Swansea Bay University Health Board
Author:
Dr. Rangaswamy Mothukuri, Lisa Fabb
Target Audience:
Healthcare professionals
Period of Action:
2021-2024
Approval Date:
November 2024
Amendment Date:
N/A
Sponsoring Organization:
Centers for Disease Control and Prevention (CDC)
Implementing Organization:
ICF
Document Type:
Focus Group Moderator’s Guide
Topic:
Sepsis education and health communication materials testing
Target Audience:
Cancer patients and their caregivers
Purpose:
Collection of feedback on sepsis knowledge and evaluation of educational materials
Format:
Structured discussion guide with scripted questions and probes
Estimated Session Duration:
Approximately 60 minutes
Components:
Welcome script, consent procedures, discussion questions, material testing segment
Referenced Material:
“Protect Yourself and Your Family from Sepsis” Fact Sheet
Data Collection Method:
Audio-recorded focus group interview
Confidentiality Provisions:
Removal of identifying information from reports
Year:
2020
Country:
Australia
Region:
Nationwide
Organisation:
Australian Group on Antimicrobial Resistance (AGAR)
Programme:
Australian Gram-negative Sepsis Outcome Programme (GnSOP)
Authors:
Jan M Bell; Alicia Fajardo Lubian; Sally R Partridge; Thomas Gottlieb; Jonathan Iredell; Denise A Daley; Geoffrey W Coombs
Type of document:
Annual surveillance report
Subject:
Antimicrobial resistance in gram-negative bloodstream infections
Pathogens studied:
Enterobacterales; Escherichia coli; Klebsiella pneumoniae; Enterobacter cloacae complex; Pseudomonas aeruginosa; Acinetobacter species
Sample size:
8,752 isolates
Study period:
1 January to 31 December 2020
Participating laboratories:
30 laboratories
Institutions covered:
49 institutions
Methodology:
Automated susceptibility testing; PCR screening; whole genome sequencing
Standards applied:
CLSI M100; EUCAST v11.0 (January 2021)
Key focus:
Resistance to third-generation cephalosporins; fluoroquinolones; piperacillin-tazobactam; carbapenems; colistin
Carbapenemase genes detected:
blaIMP-4; blaGES-5; blaNDM-1; blaNDM-5; blaOXA-48; blaOXA-181; blaIMI-1; blaOXA-23+NDM-1
Year:
2023
Region / city:
Multicenter
Topic:
Sepsis, Procalcitonin kinetics, Mortality prediction
Document type:
Supplemental Content
Organization:
Multiple medical centers
Author:
Not specified
Target audience:
Healthcare professionals, researchers in sepsis
Period of validity:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2026
Region / City:
United States (National)
Topic:
Health communication, sepsis awareness
Document type:
Focus group moderator guide
Organization:
Centers for Disease Control and Prevention (CDC), ICF
Audience:
Spanish-speaking women
Duration:
75 minutes
Content format:
Discussion guide with sections on welcome, knowledge assessment, and material testing
Materials included:
Animated video “Cuatro Maneras De Ganarle a la Septicemia”
Purpose:
Collect participant feedback on health communication materials and sepsis awareness
Document type:
Supplementary research tables and figure
Field of study:
Infectious diseases and clinical epidemiology
Topic:
Sepsis onset timing, bloodstream pathogens, and statistical analysis of clinical variables
Related condition:
Sepsis during the CIN window
Data scope:
Distribution of sepsis onset times from index time (T0; first CIN onset)
Sample size (sepsis cases):
48
Blood culture isolates analyzed:
31
Pathogen categories:
Gram-negative bacteria, Gram-positive bacteria, fungi
Key pathogens listed:
Escherichia coli; Pseudomonas aeruginosa; Viridans streptococci; Enterococcus spp; Staphylococcus aureus; Candida albicans
Statistical analysis:
Variance Inflation Factor (VIF) analysis after excluding CRP
Variables analyzed:
CAR, RDW, PLT, PCT, IL6, Oral mucosal status, Risk stratification
Figure description:
Missing data assessment for variables included in the analyses
Abbreviations defined:
CAR (C-reactive protein/albumin ratio); PCT (procalcitonin); RDW (red blood cell distribution width); PLT (platelet)
Year:
2026
Topic:
Infectious diseases, surgical site infections
Document type:
Medical reference / educational material
Target audience:
Healthcare professionals, medical students
Key terms:
Infection, bacteremia, sepsis, severe sepsis, septic shock, abscess, cellulitis, MODS, SIRS
Clinical focus:
Wound infection classification, abscess formation, systemic inflammatory responses
Treatment overview:
Drainage procedures, antibiotic therapy, systemic support
Pathogens mentioned:
Staphylococcus aureus, Gram-negative bacteria (E.coli)
Onset period:
7–10 days post-surgery for wound abscesses
Year:
2015
Region / city:
Global
Topic:
Infectious diseases, sepsis, viral and bacterial co-infections
Document type:
Scientific article
Organization / institution:
Various medical institutions and researchers
Author:
Multiple authors
Target audience:
Medical professionals, researchers in infectious diseases
Effective period:
N/A
Approval date:
2015
Modification date:
N/A
Study period:
3 years
Location:
United Kingdom
Target group:
Adults admitted to ICU with sepsis
Study type:
Clinical research trial
Interventions:
PCR diagnostic testing, fluid management trial, GM-CSF treatment trial
Number of participants:
Up to 3800 patients
Purpose:
To evaluate optimal treatments for sepsis
Sponsor:
Not specified
Consent required:
Yes
Follow-up:
3 and 6 months post-enrollment
Intervention:
Arthroscopic hip surgery
Conditions treated:
Labral tear; Femoro-Acetabular Impingement (FAI); Sepsis of the hip joint; Loose body
Document type:
Commissioning policy / clinical commissioning position
Subject area:
Orthopaedic surgery; hip joint disorders
Clinical indications:
Labral tear; Femoro-Acetabular Impingement Syndrome; septic arthritis of the native hip joint; intra-articular loose bodies following trauma
Eligibility criteria:
Defined clinical, radiological, symptomatic, and treatment history requirements including failure of conservative therapy
Target patient group:
Adults aged 18–50 years for FAI-related surgery
Authoring body:
NICE referenced; British Hip Society referenced
Register requirement:
Non-Arthroplasty Hip Surgery Register maintained by the British Hip Society
Evidence basis:
Clinical and radiological diagnosis including X-ray, MRI, and CT
Effective from:
October 2024
Policy review date:
October 2027
References:
NICE IPG408 guidance; British Orthopaedic Association guidance on hip pain in adults; British Hip Society Non-Arthroplasty Hip Registry; SANJO guideline for septic arthritis; Journal of Orthopaedic Trauma article on arthroscopic removal of loose bodies
Research Field:
Immunology
Subfield:
Host Defense and Sepsis
Experimental Model:
C57BL/6 and C57BL/6J mice
Biological Focus:
Macrophage function and bacterial clearance
Bacterial Species:
Pseudomonas aeruginosa
Laboratory Techniques:
CFU determination, ELISA, flow cytometry, Western blot, siRNA interference, fluorescence microscopy
Cell Type:
Mouse peritoneal macrophages (PMφs)
Tissues Examined:
Lung, liver, spleen, kidney
Biochemical Markers:
ALT, AST, LDH, creatinine
Cytokines and Chemokines Measured:
Prokineticin-2, TNF-α, IL-6, IL-10, IL-17A
Experimental Interventions:
rPK2 stimulation, PKR1/PKR2 siRNA transfection, macrophage depletion with clodronate liposomes
Time Points of Analysis:
24 hours and 48 hours after modeling
Detection Methods:
Hematoxylin-eosin staining, fluorescence microscopy, FACScan flow cytometry, ELISA assays
Software for Analysis:
FCM Express
Referenced Studies:
Song et al., 2016; Song et al., 2015
Animal Age:
Six- to eight-week-old mice
Year:
2023
Field:
Medicine / Critical Care Medicine / Infectious Diseases
Topic:
Corticosteroid therapy in sepsis and septic shock
Document type:
Supplementary appendix to a systematic review and meta-analysis
Methodology:
Systematic review, pairwise meta-analysis, dose-response meta-analysis
Guideline framework:
PRISMA-S, GRADE
Population studied:
People with sepsis, severe sepsis, or septic shock
Interventions analyzed:
Corticosteroids including hydrocortisone, dexamethasone, methylprednisolone, prednisolone, prednisone, cortisone, betamethasone, and fludrocortisone
Comparators:
Placebo or no corticosteroid treatment
Outcomes assessed:
Short-term mortality, long-term mortality (90–180 days), shock reversal, organ dysfunction, ICU length of stay, hospital length of stay, adverse events, quality of life
Data sources:
MEDLINE, Embase, LILACS, Cochrane Clinical Trials Register
Study design included:
Randomized controlled trials
Search date:
October 12, 2022
Literature update date:
January 10, 2023
Publication limits:
Human studies; publication year ≥ 2018
Key analytical components:
Hydrocortisone dose equivalence conversion, mineralocorticoid activity index, certainty of evidence assessment
Supplement contents:
Search strategies, trial characteristics tables, risk of bias assessments, certainty of evidence tables, PRISMA diagram, outcome figures and subgroup analyses
Year:
Not specified
Region / City:
Not specified
Subject:
Paediatric fracture management
Document type:
Clinical guidelines
Author:
Not specified
Target audience:
Healthcare professionals, specifically in paediatric fracture care
Approval date:
Not specified
Modification date:
Not specified
Year:
2026
Region / City:
United Kingdom
Topic:
Paediatric fatigue assessment and referral
Document Type:
Referral Form
Organization / Institution:
NHS
Author:
Not specified
Target Audience:
Healthcare professionals
Period of Validity:
Indefinite
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2022
Region / city:
Birmingham
Subject:
Paediatric Oncology and Haematology
Document type:
Capability Framework
Organization / institution:
Royal College of Nursing, Children’s Cancer and Leukaemia Group (CCLG)
Author:
Sally Spencer, Helen Woodman
Target audience:
Advanced Clinical Practitioners, Clinical Supervisors
Period of validity:
Until March 2023
Date of approval:
March 2022
Date of revisions:
Annually for first three years, then every three years
Year:
2022
Region / City:
ACT and surrounding NSW
Topic:
Paediatric Diabetes Care, Insulin Pump Therapy
Document Type:
Clinical Guideline
Organization:
Canberra Health Services (CHS)
Author:
Canberra Health Services, Paediatric Endocrinology and Diabetes Service
Target Audience:
Paediatric Diabetes Healthcare Providers
Period of Validity:
N/A
Approval Date:
N/A
Date of Last Revision:
N/A
Year:
2023
Region / City:
Canberra
Topic:
Paediatric Parenteral Nutrition
Document Type:
Guideline
Organization / Institution:
Canberra Health Services
Author:
SCHN Multidisciplinary Team
Target Audience:
Clinicians, Parents/Carers
Effective Period:
Not specified
Approval Date:
13/06/2023
Amendment Date:
13/06/2023