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Supplementary research material presenting tabulated data and a figure on sepsis onset distribution, pathogen isolates from positive blood cultures, and multicollinearity assessment of clinical variables within analyses related to the CIN time window.
Document type: Supplementary research tables and figure
Field of study: Infectious diseases and clinical epidemiology
Topic: Sepsis onset timing, bloodstream pathogens, and statistical analysis of clinical variables
Related condition: Sepsis during the CIN window
Data scope: Distribution of sepsis onset times from index time (T0; first CIN onset)
Sample size (sepsis cases): 48
Blood culture isolates analyzed: 31
Pathogen categories: Gram-negative bacteria, Gram-positive bacteria, fungi
Key pathogens listed: Escherichia coli; Pseudomonas aeruginosa; Viridans streptococci; Enterococcus spp; Staphylococcus aureus; Candida albicans
Statistical analysis: Variance Inflation Factor (VIF) analysis after excluding CRP
Variables analyzed: CAR, RDW, PLT, PCT, IL6, Oral mucosal status, Risk stratification
Figure description: Missing data assessment for variables included in the analyses
Abbreviations defined: CAR (C-reactive protein/albumin ratio); PCT (procalcitonin); RDW (red blood cell distribution width); PLT (platelet)
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Young onset and rarer forms of dementia Collated national resources
Year: 2024
Region / city: Greater Manchester
Subject: Dementia, Health Resources
Document Type: Collated Resource Guide
Organization / Institution: Dementia United
Author: Dementia United, Jacqui Cannon, Lewy Body Society
Target audience: People affected by dementia, carers, practitioners
Period of validity: Ongoing (reviewed twice yearly)
Approval date: October 2024
Modification date: October 2024
Context: Collated resources from external organizations aimed at providing information and support for those affected by young onset and rarer forms of dementia.
The ABBRUPT Trial: A Randomised Controlled Trial of Amiodarone versus Beta Blockade for New Onset Atrial Fibrillation in Intensive Care Units in the UK
Acronym: ABBRUPT
Organ / Institution: University of Birmingham
Unit: Birmingham Clinical Trials Unit (BCTU)
Trial Office: ABBRUPT Trial Office
Country: United Kingdom
Regulatory Framework: UK Data Protection Regulations
Policy Framework: UK Policy Framework for Health and Social Care Research
Trial Design: Pragmatic open-label interventional multi-centre two-arm randomised controlled trial with internal pilot and economic evaluation
Objectives: To compare clinical and cost effectiveness of beta blockers versus amiodarone for new onset atrial fibrillation in intensive care and to conduct cost-effectiveness and cost-utility analyses at 90-day follow-up
Target Population: Patients aged 16 years and over in intensive care units with new onset atrial fibrillation
Sample Size: 2560 patients
Setting: At least 60 intensive care units across the UK
Interventions: Amiodarone versus beta blockers (including bisoprolol, metoprolol, esmolol, propranolol, atenolol, labetalol, carvedilol, landiolol)
Primary Outcome: 90-day mortality
Secondary Outcomes: Clinical and economic outcomes including ICU and hospital measures
Eligibility Criteria: Defined inclusion and exclusion criteria for patients with new onset atrial fibrillation in ICU
Data Management: Contact details retained indefinitely on a BCTU database and subject to written request under UK Data Protection Regulations
Oversight Requirements: Approval required from relevant Trust or Health Board Management prior to patient consent
Consent Requirements: Written informed consent and participant information sheet on Trust/Health Board headed paper
Local Governance: Compliance with Good Clinical Practice and UK Policy Framework for Health and Social Care Research
Hormone Replacement Therapy and Asthma Onset in Menopausal Women: National Cohort Study
Year: 2023
Region / City: United Kingdom
Topic: Hormone replacement therapy, asthma, menopause
Document Type: Research study
Organization / Institution: University of Edinburgh, Asthma UK
Author: Syed A Shah, Holly Tibble, Rebecca Pillinger, Susannah McLean, Dermot Ryan, Hilary Critchley, David Price, Catherine M Hawrylowicz, Colin R Simpson, Ireneous N Soyiri, Francis Appiagyei, Aziz Sheikh, Bright I Nwaru
Target Audience: Researchers, healthcare professionals
Study Period: 1/1/2000 – 12/31/2016
Approval Date: 2023
Funding: Asthma UK, Health Data Research UK
Conflicts of Interest: No conflicts of interest declared
Methodology: Longitudinal cohort study, multilevel Cox regression models
Conclusion Date: 2023
Supplementary MaterialSearch strategyEMBASE 1379 Results 'psychosis'/exp OR 'schizophrenia spectrum disorder'/exp(schizo* OR psychotic* OR psychosis OR psychoses OR hebephreni* OR oligophreni*):ti,ab((chronic* OR sever*) Near/5 mental* NEAR/5 (ill* OR disorder*)):ti,ab#1 OR #2 OR #3((risk* NEAR/3 schiz*) OR (screen* NEAR/3 schiz*)):ti,ab ((duration OR length) NEAR/3 untreat*):ti,ab((first OR initial OR primary) NEAR/3 (admission* OR hospital* OR episod* OR breakdown*)):ti,ab((early OR ‘first episode’ OR ‘first onset’) NEAR/3 (intervent* OR treat* OR recogni* OR detect*)):ti,ab(delay* NEAR/3 treat*):ti,ab('(DUP)' OR premorbid* OR prodrom*):ti,ab#5 OR #6 OR #7 OR #8 OR #9 OR #10
Year: 2023
Region / City: Global
Topic: Mental Health, Psychosis, Schizophrenia
Document Type: Research Protocol / Search Strategy
Organization: N/A
Author: N/A
Target Audience: Researchers, Mental Health Professionals
Effective Period: N/A
Approval Date: N/A
Revision Date: N/A
Keywords: psychosis, schizophrenia, risk, treatment, early intervention, qualitative research, search strategy
Childhood, Adolescent and Adult Age at Onset and Related Clinical Correlates in Obsessive-Compulsive Disorder: A Report from the International College of Obsessive-Compulsive Disorders
Year: 2021
Region / City: International
Theme: Obsessive-Compulsive Disorder, Age of Onset
Document Type: Research Report
Target Audience: Mental Health Professionals, Researchers
Period of Validity: Not specified
Approval Date: Not specified
Date of Changes: Not specified
Number of Pages: 7
Number of References: 33
Number of Figures: 2
Number of Tables: 2
Clinical Trial Number: Not available
Keywords: Obsessive-compulsive disorder (OCD), age at onset (AAO), childhood-onset, adolescent-onset, adult-onset, cognitive behavioral therapy (CBT)
Contextual Description: A clinical research report discussing the prevalence and clinical characteristics of OCD based on age at onset, comparing childhood, adolescent, and adult onset groups in an international multicenter study.
Topics: Multicollinearity CIN-Associated onset