№ files_lp_4_process_3_095138
Research article integrating ENCODE functional genomics data with tumor molecular profiles to map regulatory changes in non-coding regions and assess their role in cancer development and prognosis.
Year: 2026
Field: Genomics, Cancer Research
Document type: Research Article
Institution: ENCODE Consortium
Author: Not specified
Target audience: Researchers in cancer genomics
Data sources: ENCODE functional genomics, TCGA tumor profiles
Methods: Integration of functional genomics with tumor molecular profiles, hierarchical regulatory network analysis, mutation prioritization
Key findings: Identification of non-coding mutations, regulatory network rewiring, functional validation in cancer cell lines
Cancer types studied: Blood, liver, lung, breast, cervix
Experimental validation: siRNA knockdown, luciferase assays
Scope: Human genome non-coding regions
Integration date: 2026
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