№ lp_2_1_06469
File format: docx
Character count: 2495
File size: 526 KB
Note:
Year
Subject:
Pharmacology
Document type:
Research methodology
Target audience:
Researchers, Pharmacologists
Description:
This document provides the experimental setup, assay parameters, and performance data for the analysis of venetoclax and voriconazole in a pharmacokinetic study.
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2023-2025
Region / Location:
United States
Subject:
Avian pharmacology, parasitology, and infectious diseases
Document type:
Research summaries and pilot studies
Institutions:
Various veterinary and wildlife research journals
Authors:
Sharmie D. Johnson, Andreas Lehner, Levent Dirikolu, John Buchweitz, Kelsey Trumpp, Alison Jeffrey, André A. Dhondt, María Teresa Reinoso-Pérez, KE Powers, et al.
Target species:
Common raven (Corvus corax), house finch (Haemorhous mexicanus), domestic pigeons (Columba livia domestica), Gouldian finches (Chloebia gouldiae), American robins (Turdus migratorius), and other zoo birds
Study focus:
Drug interactions, disease co-infections, pathogen spillover, avian mortality events, and parasite life cycles
Methodology:
Pilot studies, retrospective evaluations, histopathology, pharmacokinetics, and field observations
Key findings:
Ciprofloxacin maintains therapeutic voriconazole levels; co-infection increases heterophil:lymphocyte ratios; capromorelin affects pecking behavior; Mycoplasma gallisepticum shows regional evolutionary differences; ethanol and Plagiorhynchus contribute to mass mortality in American robins
Time frame:
Data collected and analyzed between 2023 and 2025
Peer-reviewed:
Yes
Year:
2021
Region / city:
Australia
Topic:
Pharmaceutical Drug Submission
Document type:
Resubmission Request
Organization / institution:
PBAC
Author:
AbbVie Pty Ltd.
Target audience:
Healthcare professionals, PBAC
Validity period:
Not specified
Approval date:
2021
Date of amendments:
Not specified
Medicine:
Venetoclax
Brand name:
Venclexta®
Sponsor:
AbbVie Pty Ltd
Dosage forms:
Tablets 10 mg, 50 mg, 100 mg
Pack types:
Titration pack; Dose hold packs; Maintenance pack
Regulatory authority:
Pharmaceutical Benefits Advisory Committee (PBAC)
Regulatory process:
TGA/PBAC Parallel Process
ARTG registration date:
5 January 2017
Requested listing:
Section 85 Authority Required (PBS)
Indication:
Relapsed/refractory chronic lymphocytic leukaemia (CLL)
Patient subgroup:
17p deletion and/or TP53 mutation; highly refractory disease
Comparator:
Ofatumumab monotherapy; Rituximab monotherapy
Related assessments:
MSAC streamlined co-dependent assessment pathway
Clinical context:
Second- and third-line therapy in relapsed/refractory CLL
Document type:
PBS listing submission summary
Year:
2023
Region / City:
-
Subject:
Immunology, Diagnostic Assay
Document Type:
Technical Manual
Organization:
-
Author:
-
Target Audience:
Laboratory Professionals
Period of Validity:
-
Approval Date:
-
Modification Date:
-
Year:
2025
Note:
Region / City
Theme:
Seed amplification assay innovation
Document Type:
Application Instructions
Target Audience:
Researchers in scientific and clinical fields
Effective Period:
Spring 2025
Year:
2023
Region / city:
Global
Topic:
Cell proliferation assay
Document type:
Kit instruction manual
Organization:
Abcam
Author:
Abcam Technical Team
Target audience:
Researchers, lab technicians
Period of validity:
1 year from receipt
Approval date:
2023
Date of modifications:
None
Storage conditions:
Store at -20°C in the dark
Components:
MTT Reagent, MTT Solvent
Required materials (not supplied):
Microplate reader, pipettes, 96 well plate
Safety notes:
Wear gloves, lab coat, and protective eyewear; handle reagents with care
Assay procedure:
Detailed protocol for measuring cell proliferation using MTT reagent
Interferences:
Serum or phenol red in culture medium may cause background interference
FAQ:
Instructions for background control, handling of MTT reagent, and troubleshooting
Contextual description:
Instruction manual for a research kit used to measure cell proliferation in cultured cells.
Document type:
Materials and Methods section
Species:
C57Bl6/J mice; Sprague Dawley rats
Animal source:
The Jackson Laboratories (Bar Harbor, Maine); Zhejiang Vital River Laboratory Animal Technology Co., Ltd.
Experimental facilities:
BioDuro-Sundia (Shanghai, China)
Ethics approval:
IACUC approved protocols
Regulatory compliance:
Animal Welfare Act (9 CFR Parts 1–3); Guide for the Care and Use of Laboratory Animals (8th Edition); AAALAC accreditation (001516)
Cell lines:
YPMK; YPMK PINK1 KO; EPF1; HEK293 PINK1 KO; SK-OV-3; ΔOTC
Primary cultures:
Mouse hippocampal and cortical neurons (E16, A53T α-synuclein M83 mice)
Key assay:
SMCxPRO pUb assay
Key reagents:
Rabbit anti-pS65-Ub antibody (CST E2J6T); Mouse anti-Ub antibody (CST P4D1); K48 pUb tetramers (RnD Systems UC-250)
Instrumentation:
SMCxPRO system; Agilent Seahorse XFe96 analyzer; ImageXpress Micro Confocal High-Content Imaging System
Experimental focus:
α-synuclein preformed fibrils (PFFs); mitochondrial respiration; mitophagy measurement (MT-mKeima)
Data availability:
Available from corresponding author upon reasonable request under Material Transfer Agreement
Code availability:
No original code reported
Year:
Not specified
Region / city:
Not specified
Subject:
Serum protein binding, small proteins
Document type:
Protocol
Organization / institution:
Not specified
Author:
Not specified
Target audience:
Researchers, scientists
Effective period:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2021
Region / city:
Queensland, Australia
Topic:
miRNA expression analysis, pleural effusions, extracellular vesicles
Document type:
Research article
Institution:
The University of Queensland Thoracic Research Centre, The Prince Charles Hospital
Authors:
Tian Mun Chee, Caeli J. Zahra, Kwun M. Fong, Ian A. Yang, Rayleen V. Bowman
Target audience:
Researchers in molecular biology, oncology
Period of validity:
N/A
Approval date:
N/A
Date of changes:
N/A
Knockeen Trenching and New Assay Sampling Programme to Commence at Leinster Lithium Project, Ireland
Year:
2023
Region / City:
Leinster, Ireland
Theme:
Lithium exploration, Mining
Document Type:
Press Release
Organization:
Technology Minerals Plc, Global Battery Metals Ltd
Author:
Alex Stanbury, Michael Murphy
Target Audience:
Investors, Industry professionals
Period of validity:
Up to two years
Approval Date:
23 November 2023
Amendment Date:
-
Year:
2021
Region / city:
Towers Lab, International
Topic:
HIV Research, DNA-Sensing Pathways, Viral Proteins
Document Type:
Scientific Research Paper
Organization / Institution:
Towers Lab
Author:
James Cai
Target Audience:
Researchers, Scientists, Molecular Biologists
Period of Action:
Not specified
Date of Approval:
Not specified
Date of Modifications:
Not specified
Product Name:
6-Phosphogluconate Dehydrogenase Assay Kit (ab241016)
Version:
2a
Last Updated:
24 August 2023
Manufacturer:
Abcam
Former Brand:
BioVision
Intended Use:
Research use only, not for diagnostic use
Analyte:
6-Phosphogluconate Dehydrogenase (6-PGD)
Detection Method:
Colorimetric, absorbance at 460 nm
Sample Types:
Tissue homogenates; adherent and suspension cells
Storage Conditions:
-20°C, protected from light
Kit Stability:
1 year from receipt if components are not reconstituted
Assay Temperature:
37°C
Measurement Mode:
Kinetic and endpoint spectrophotometric analysis
Unit Definition:
One unit generates 1.0 µmole of NADPH per min at pH 8.0 at 37°C
Document Type:
Laboratory assay kit instruction manual
Copyright:
© 2023 Abcam. All Rights Reserved.
Year:
2020
Region / City:
United Kingdom
Topic:
Biochemical Assay
Document Type:
Datasheet
Organization:
Abcam
Author:
Abcam
Target Audience:
Researchers
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2023
Region / city:
Parkville, Victoria, Australia
Topic:
Immunofluorescence, laboratory techniques
Document type:
Laboratory protocol
Organization:
Walter and Eliza Hall Institute of Medical Research
Author:
Thanh Ngoc Nguyen
Target audience:
Laboratory researchers, biotechnologists
Date of approval:
Not specified
Date of changes:
Not specified
Year:
N/A
Region / City:
N/A
Subject:
Biochemical Analysis
Document Type:
Methodology
Institution:
N/A
Author:
N/A
Target Audience:
Laboratory technicians, researchers
Period of Use:
N/A
Approval Date:
N/A
Date of Revision:
N/A
This document describes a biochemical method for measuring ALT (SGPT) activity in serum samples using two different assay techniques:
discontinuous (colorimetric) and continuous (UV/kinetic).
Year:
2019
Region / City:
United States
Subject:
Toxicology Testing
Document Type:
Data Release
Organization / Institution:
United States Environmental Protection Agency (EPA)
Author:
Monica Linnenbrink
Target Audience:
Researchers, Toxicologists, Environmental Scientists
Period of Action:
March 2019
Approval Date:
March 2019
Revision Date:
Not specified