№ lp_2_1_17961
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This document is a referral form for patients suspected of having bone or soft tissue tumours, outlining the required clinical details for the Oncology Multi-Disciplinary Team at the Royal Orthopaedic Hospital.
Year:
2022
Region / city:
Birmingham, UK
Topic:
Medical Referral
Document type:
Referral Form
Organization:
Royal Orthopaedic Hospital
Author:
Not specified
Target audience:
Healthcare professionals, referring consultants
Effective period:
Not specified
Approval date:
Not specified
Amendment date:
Not specified
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Document type:
Supplementary material
Scientific field:
Molecular biology
Research focus:
Anticalin selection and affinity maturation
Target protein:
Membrane-bound Hsp70
Methodology:
Bacterial surface display
Techniques:
FACS screening, affinity maturation, directed evolution, SPR, CD spectroscopy, flow cytometry
Biological models:
E. coli, FaDu cells, OPM-2 cells
Authors:
Lars Friedrich; Petra Kornberger; Claudia T. Mendler; Gabriele Multhoff; Markus Schwaiger; Arne Skerra
Figures included:
Figures S1–S7
Related publication:
Main research article on Anticalin selection against Hsp70
Experimental scope:
In vitro binding analysis and cellular characterization
Note:
Year
Note:
Year
Note:
Year
Subject:
Medical referral
Document type:
Referral form
Organization / Institution:
The Royal Orthopaedic Hospital
Target audience:
Healthcare professionals, medical specialists
Contextual description:
Form for referring patients to the Bone Tumour Service at The Royal Orthopaedic Hospital, including details about patient history, diagnosis, and referral process.
Year:
2023
Region / City:
London, Norwich, Liverpool, UK
Topic:
Medical Research
Document Type:
Systematic Review with Meta-Analysis
Author:
Tristan D Boam, Melissa Gabriel, Rajeev Shukla, Paul D Losty
Target Audience:
Healthcare professionals, researchers in paediatric oncology
Period of Effect:
1990-2020
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / city:
Not specified
Topic:
Cancer research, muscle index, and treatment effects
Document type:
Research table
Organization / institution:
Not specified
Author:
Not specified
Target audience:
Researchers, medical professionals
Period of validity:
Not applicable
Approval date:
Not specified
Date of changes:
Not specified
Year:
2023
Region / City:
Manchester
Subject:
Genomic testing for cancer types
Document Type:
Medical Form
Organization:
North West Genomic Laboratory Hub
Author:
North West Genomic Laboratory Hub
Target Audience:
Medical professionals, Pathologists
Validity Period:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2021
Organisation:
International Collaboration on Cancer Reporting
Document type:
Histopathology reporting guide
Subject:
Gastrointestinal stromal tumour (GIST)
Scope:
Pathology reporting of resection specimens for GIST
Exclusions:
Metastatic GIST specimens
Edition:
1st edition
Applicable staging system:
Pathological TNM staging
Evidence framework:
NHMRC levels of evidence
Intended users:
Pathologists reporting GIST resection specimens
Related publications:
Gastrointestinal Stromal Tumour (GIST) Histopathology Reporting Guide – Biopsy Specimens; Soft Tissue Sarcoma Histopathology Reporting Guide – Resection Specimens
Year:
2023
Region / City:
United Kingdom
Topic:
Genomic Testing, Tumour Referral
Document Type:
Referral Form
Organization / Institution:
NW Genomic Laboratory Hub
Author:
Not specified
Target Audience:
Clinicians, Medical Professionals
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / Institution:
Multiple international research centers including 4HF Biotec GmbH, Oncotest GmbH, Charles River Discovery Research Services Germany GmbH
Subject Area:
Oncology, Pharmacology, Molecular Biology
Document Type:
Supplementary Material / Research Data
Experimental Models:
Patient-derived xenografts (PDX), Cell line-derived xenografts (CDX), Cell lines, Mouse tumour models
Methods:
RNA expression analysis (TPM), Affymetrix GeneChip arrays, SNP6.0 arrays, Whole-exome sequencing, Mass cytometry, Radiomics-based CT scans
Drug:
Rogenolisib (IOA-244)
Patient Cohorts:
Solid tumour patients, mUM, mCM, NHL-FL, mesothelioma
Endpoints:
Burden of therapy, Treatment-emergent adverse events (TEAEs), CD63+ basophils, Tumour lesion changes, Cell-free DNA, Protein expression levels, Immunoglobulin levels
Analyses:
Kaplan–Meier survival analysis, ANOVA, Linear mixed effect models, Correlation analyses
Timepoints:
Baseline to Week 16, up to Cycle 5 for patient-reported outcomes
Genetic Data:
SNVs, insertions/deletions, TMB, selected gene variants
Year:
2026
Region / City:
Multicenter, Europe
Subject:
Nuclear medicine dosimetry for neuroendocrine tumors
Document type:
Supplementary material / Research methods
Institution:
Siemens A.G., Symbia T6 imaging centers
Author:
Clinical imaging research team
Target audience:
Medical physicists, nuclear medicine specialists
Study period:
4-, 24-, and 72-hours post-injection imaging
Radiopharmaceutical:
177Lu-DOTA-octreotate
Analytical methods:
SPECT/CT quantitation with attenuation, dead-time, and scatter correction, three-phase exponential time-activity curve fitting
Outcome:
Tumour dose factors and population standard deviation
Year:
2023
Region / city:
N/A
Topic:
Immune cell characterization, ICOS expression, tumour immunology
Document type:
Research figure legends
Organization / institution:
N/A
Author:
N/A
Target audience:
Researchers in immunology and oncology
Duration of action:
N/A
Approval date:
N/A
Date of changes:
N/A
Year:
2026
Research Area:
Immunology, Cancer Biology
Document Type:
Scientific Article Supplementary Data
Authors:
Guoying Ni et al.
Organ / Institution:
Not specified
Experimental Model:
TC-1 tumour-bearing mice
Treatments:
Caerin 1.1/1.9 peptides, P3, PD-1 blockade
Cell Types Studied:
Macrophages, B cells, NK cells, Dendritic cells, T cells
Methods:
Single-cell RNA sequencing, GO and KEGG enrichment analysis
Key Findings:
Modulation of immune cell populations and activation pathways in tumour microenvironment
Supplementary Figures:
13A-F, 14A-F
Year:
2018
Region / Institution:
University of British Columbia
Subject:
Laboratory animal welfare and tumour monitoring
Document type:
Protocol / Guidelines
Responsible organization:
Animal Care and Ethics Committee
Authors:
Ullman-Culleré M.H., Foltz C.J., et al.
Target audience:
Laboratory animal researchers and veterinarians
Monitoring period:
Daily post-procedure observations
Date of publication:
2018
References:
https://animalcare.ubc.ca/sites/default/files/documents/Tumour%20Ulceration%20Guideline%202018%20final.pdf, Olfert et al. 1998, Jensen et al. 2008, Morton 2000
Year:
2026
Region / city:
Not specified
Topic:
Genome and Transcriptome Sequencing
Document Type:
Research paper
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, bioinformaticians
Validity period:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Organisation:
Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust
Type of document:
Early market engagement briefing
Sector:
Healthcare
Specialty:
Orthopaedics
Geographic scope:
North West England
Location:
Wrightington Hospital, Wigan
Year:
2024
Purpose:
Exploration of partnership opportunities for private orthopaedic patient services
Partnership model:
Strategic multi-phase public–private partnership
Current private provision:
John Charnley Wing
Private patient income:
£6.6 million (2024/25)
Strategic framework:
Wrightington Strategy 2023–2030
Regulatory context:
NHS Foundation Trust
Market focus:
UK private orthopaedic healthcare market
Target partners:
Experienced private healthcare providers
Source type:
Institutional briefing and market engagement material
Author:
Jonathan Ashmore
MRSE:
Gillian McNaught
Radiographer:
Heather Boylan
Authorisation date:
11/3/25 (NHS Scotland MR Physics group)
Review Date:
11/3/28
Note:
Version History
Type of document:
Procedure statement
Clinical context:
Orthopaedic implants are used to treat and support damaged bones and other structures, and the document covers the safety procedures for MRI scanning of internal orthopaedic implants.
Risk Assessment:
The document includes a risk assessment for MRI scanning of internal orthopaedic implants, outlining various risks and safety measures.
Period of validity:
From the authorisation date until the review date
Safety considerations:
Details the risks associated with MRI scanning of internal orthopaedic implants and offers a structured risk assessment for each type.
intended audience:
Medical professionals involved in MRI scanning of orthopaedic implants
Evidence review:
This section presents evidence supporting the adoption of Generic Implant Safety Procedures (GISPs) for MRI scanning of orthopaedic implants.
Discussion:
An optional section offering insights into the implementation and challenges of adopting GISPs.
Year:
2024
Region / City:
Ireland
Subject:
Climate action, sustainability, energy efficiency, hospital infrastructure
Document Type:
Climate action roadmap
Institution:
National Orthopaedic Hospital Cappagh (NOHC)
Author:
Not specified
Target Audience:
Healthcare professionals, hospital management, environmental and sustainability stakeholders
Period of validity:
2024–2030
Approval Date:
Not specified
Amendment Date:
Not specified
Year:
2023
Region / city:
Neath Port Talbot, Swansea Bay, Wales
Topic:
Orthopaedic and spinal healthcare services
Document type:
Public engagement report
Organization:
Swansea Bay University Health Board
Target audience:
Patients, families, carers, local community
Period of engagement:
20 February 2023 to 14 April 2023
Hospitals involved:
Neath Port Talbot Hospital, Morriston Hospital, Singleton Hospital, Princess of Wales Hospital
Staff:
Approximately 12,500 employees
Population covered:
Around 390,000 residents
Budget:
£1 billion annually
Service scope:
Orthopaedics, spinal care, diagnostics, urology, rehabilitation, rheumatology
Note:
Year
Subject:
Medical referral
Document type:
Referral form
Organization / Institution:
The Royal Orthopaedic Hospital
Target audience:
Healthcare professionals, medical specialists
Contextual description:
Form for referring patients to the Bone Tumour Service at The Royal Orthopaedic Hospital, including details about patient history, diagnosis, and referral process.