№ files_lp_4_process_3_080056
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Structured protocol for observing clinical signs, body condition, and tumour progression in laboratory rodents, including scoring systems for posture, movement, coat, feeding, breathing, dehydration, eyes/nose, faeces, urination, and tumour characteristics.
Year:
2018
Region / Institution:
University of British Columbia
Subject:
Laboratory animal welfare and tumour monitoring
Document type:
Protocol / Guidelines
Responsible organization:
Animal Care and Ethics Committee
Authors:
Ullman-Culleré M.H., Foltz C.J., et al.
Target audience:
Laboratory animal researchers and veterinarians
Monitoring period:
Daily post-procedure observations
Date of publication:
2018
References:
https://animalcare.ubc.ca/sites/default/files/documents/Tumour%20Ulceration%20Guideline%202018%20final.pdf, Olfert et al. 1998, Jensen et al. 2008, Morton 2000
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Document type:
Supplementary material
Scientific field:
Molecular biology
Research focus:
Anticalin selection and affinity maturation
Target protein:
Membrane-bound Hsp70
Methodology:
Bacterial surface display
Techniques:
FACS screening, affinity maturation, directed evolution, SPR, CD spectroscopy, flow cytometry
Biological models:
E. coli, FaDu cells, OPM-2 cells
Authors:
Lars Friedrich; Petra Kornberger; Claudia T. Mendler; Gabriele Multhoff; Markus Schwaiger; Arne Skerra
Figures included:
Figures S1–S7
Related publication:
Main research article on Anticalin selection against Hsp70
Experimental scope:
In vitro binding analysis and cellular characterization
Note:
Year
Note:
Year
Note:
Year
Subject:
Medical referral
Document type:
Referral form
Organization / Institution:
The Royal Orthopaedic Hospital
Target audience:
Healthcare professionals, medical specialists
Contextual description:
Form for referring patients to the Bone Tumour Service at The Royal Orthopaedic Hospital, including details about patient history, diagnosis, and referral process.
Year:
2023
Region / City:
London, Norwich, Liverpool, UK
Topic:
Medical Research
Document Type:
Systematic Review with Meta-Analysis
Author:
Tristan D Boam, Melissa Gabriel, Rajeev Shukla, Paul D Losty
Target Audience:
Healthcare professionals, researchers in paediatric oncology
Period of Effect:
1990-2020
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2022
Region / city:
Birmingham, UK
Topic:
Medical Referral
Document type:
Referral Form
Organization:
Royal Orthopaedic Hospital
Author:
Not specified
Target audience:
Healthcare professionals, referring consultants
Effective period:
Not specified
Approval date:
Not specified
Amendment date:
Not specified
Year:
2023
Region / city:
Not specified
Topic:
Cancer research, muscle index, and treatment effects
Document type:
Research table
Organization / institution:
Not specified
Author:
Not specified
Target audience:
Researchers, medical professionals
Period of validity:
Not applicable
Approval date:
Not specified
Date of changes:
Not specified
Year:
2023
Region / City:
Manchester
Subject:
Genomic testing for cancer types
Document Type:
Medical Form
Organization:
North West Genomic Laboratory Hub
Author:
North West Genomic Laboratory Hub
Target Audience:
Medical professionals, Pathologists
Validity Period:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2021
Organisation:
International Collaboration on Cancer Reporting
Document type:
Histopathology reporting guide
Subject:
Gastrointestinal stromal tumour (GIST)
Scope:
Pathology reporting of resection specimens for GIST
Exclusions:
Metastatic GIST specimens
Edition:
1st edition
Applicable staging system:
Pathological TNM staging
Evidence framework:
NHMRC levels of evidence
Intended users:
Pathologists reporting GIST resection specimens
Related publications:
Gastrointestinal Stromal Tumour (GIST) Histopathology Reporting Guide – Biopsy Specimens; Soft Tissue Sarcoma Histopathology Reporting Guide – Resection Specimens
Year:
2023
Region / City:
United Kingdom
Topic:
Genomic Testing, Tumour Referral
Document Type:
Referral Form
Organization / Institution:
NW Genomic Laboratory Hub
Author:
Not specified
Target Audience:
Clinicians, Medical Professionals
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / Institution:
Multiple international research centers including 4HF Biotec GmbH, Oncotest GmbH, Charles River Discovery Research Services Germany GmbH
Subject Area:
Oncology, Pharmacology, Molecular Biology
Document Type:
Supplementary Material / Research Data
Experimental Models:
Patient-derived xenografts (PDX), Cell line-derived xenografts (CDX), Cell lines, Mouse tumour models
Methods:
RNA expression analysis (TPM), Affymetrix GeneChip arrays, SNP6.0 arrays, Whole-exome sequencing, Mass cytometry, Radiomics-based CT scans
Drug:
Rogenolisib (IOA-244)
Patient Cohorts:
Solid tumour patients, mUM, mCM, NHL-FL, mesothelioma
Endpoints:
Burden of therapy, Treatment-emergent adverse events (TEAEs), CD63+ basophils, Tumour lesion changes, Cell-free DNA, Protein expression levels, Immunoglobulin levels
Analyses:
Kaplan–Meier survival analysis, ANOVA, Linear mixed effect models, Correlation analyses
Timepoints:
Baseline to Week 16, up to Cycle 5 for patient-reported outcomes
Genetic Data:
SNVs, insertions/deletions, TMB, selected gene variants
Year:
2026
Region / City:
Multicenter, Europe
Subject:
Nuclear medicine dosimetry for neuroendocrine tumors
Document type:
Supplementary material / Research methods
Institution:
Siemens A.G., Symbia T6 imaging centers
Author:
Clinical imaging research team
Target audience:
Medical physicists, nuclear medicine specialists
Study period:
4-, 24-, and 72-hours post-injection imaging
Radiopharmaceutical:
177Lu-DOTA-octreotate
Analytical methods:
SPECT/CT quantitation with attenuation, dead-time, and scatter correction, three-phase exponential time-activity curve fitting
Outcome:
Tumour dose factors and population standard deviation
Year:
2023
Region / city:
N/A
Topic:
Immune cell characterization, ICOS expression, tumour immunology
Document type:
Research figure legends
Organization / institution:
N/A
Author:
N/A
Target audience:
Researchers in immunology and oncology
Duration of action:
N/A
Approval date:
N/A
Date of changes:
N/A
Year:
2026
Research Area:
Immunology, Cancer Biology
Document Type:
Scientific Article Supplementary Data
Authors:
Guoying Ni et al.
Organ / Institution:
Not specified
Experimental Model:
TC-1 tumour-bearing mice
Treatments:
Caerin 1.1/1.9 peptides, P3, PD-1 blockade
Cell Types Studied:
Macrophages, B cells, NK cells, Dendritic cells, T cells
Methods:
Single-cell RNA sequencing, GO and KEGG enrichment analysis
Key Findings:
Modulation of immune cell populations and activation pathways in tumour microenvironment
Supplementary Figures:
13A-F, 14A-F
Year:
2026
Region / city:
Not specified
Topic:
Genome and Transcriptome Sequencing
Document Type:
Research paper
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, bioinformaticians
Validity period:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2023
Region / City:
Bloomington, Indiana
Topic:
Anesthesia and Analgesia in Laboratory Animals
Document Type:
Guideline
Institution:
Indiana University Bloomington Laboratory Animal Resources
Author:
Veterinary Staff, Indiana University Bloomington Laboratory Animal Resources
Target Audience:
Research personnel working with laboratory rats
Effective Period:
Not specified
Approval Date:
Not specified
Revision Date:
Not specified
Document type:
Materials and Methods section
Species:
C57Bl6/J mice; Sprague Dawley rats
Animal source:
The Jackson Laboratories (Bar Harbor, Maine); Zhejiang Vital River Laboratory Animal Technology Co., Ltd.
Experimental facilities:
BioDuro-Sundia (Shanghai, China)
Ethics approval:
IACUC approved protocols
Regulatory compliance:
Animal Welfare Act (9 CFR Parts 1–3); Guide for the Care and Use of Laboratory Animals (8th Edition); AAALAC accreditation (001516)
Cell lines:
YPMK; YPMK PINK1 KO; EPF1; HEK293 PINK1 KO; SK-OV-3; ΔOTC
Primary cultures:
Mouse hippocampal and cortical neurons (E16, A53T α-synuclein M83 mice)
Key assay:
SMCxPRO pUb assay
Key reagents:
Rabbit anti-pS65-Ub antibody (CST E2J6T); Mouse anti-Ub antibody (CST P4D1); K48 pUb tetramers (RnD Systems UC-250)
Instrumentation:
SMCxPRO system; Agilent Seahorse XFe96 analyzer; ImageXpress Micro Confocal High-Content Imaging System
Experimental focus:
α-synuclein preformed fibrils (PFFs); mitochondrial respiration; mitophagy measurement (MT-mKeima)
Data availability:
Available from corresponding author upon reasonable request under Material Transfer Agreement
Code availability:
No original code reported
Year:
Not specified
Species:
Sprague Dawley rats
Exposure period:
GD14–18
Substances tested:
18-chemical anti-androgen mixture
Sample size:
Number of fetuses and litters per group reported
Endpoints measured:
Testosterone production, anogenital distance, nipple retention, puberty onset, reproductive organ weights, malformations, gene expression
Gene analysis:
Custom fetal rat testis gene expression array at GD18
Study type:
Experimental in vivo toxicology study
Year:
2024
Region / City:
Nigeria
Topic:
Nephrotoxicity, Herbal Medicine
Document Type:
Research Article
Institution:
Nnamdi Azikiwe University
Author:
Johnson & Dike
Target Audience:
Researchers, Medical Professionals
Period of Validity:
Not specified
Approval Date:
2024
Date of Revision:
Not specified
Year:
1926
Region / City:
N/A
Theme:
Labour, exploitation, maritime life
Document Type:
Literary analysis / narrative
Organization / Institution:
N/A
Author:
Eric Walrond, James Hanley, George Garrett
Target Audience:
Literary scholars, students, readers of maritime and labour literature
Effective Period:
N/A
Approval Date:
N/A
Date of Changes:
N/A