№ files_lp_4_process_3_112345
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The document outlines a laboratory protocol for protein analysis from serum samples using LC-MS/MS, including steps for sample preparation, protein digestion, mass spectrometry analysis, and data processing.
Year:
2023
Region / City:
USA
Topic:
Proteomics
Document Type:
Research Protocol
Author:
Not specified
Target Audience:
Researchers in proteomics
Date of Approval:
Not specified
Date of Changes:
Not specified
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Year:
2026
Region:
Not specified
Document type:
Supplementary material / Research data
Methods:
LC-MS/MS, IP–HILIC–MS/MS
Analytes:
Tenofovir (TFV), Tenofovir-diphosphate (TFV-DP)
Sample types:
Urine, Dried Blood Spots (DBS)
Target population:
Participants on antiretroviral therapy (ART)
Measured variables:
Urine TFV concentration, DBS TFV-DP concentration, POC TFV results, self-reported adherence, viral load, drug resistance
Instrument:
Agilent HPLC coupled to AB Sciex 5500 triple quadrupole mass spectrometer
Software:
Analyst v1.6.2
Detection method:
Negative-ion multiple reaction monitoring (MRM)
Tables included:
S1, S2, S3, S4
Year:
2026
Region / City:
Germany
Topic:
Analytical Chemistry, Isotope Dilution, Mass Spectrometry
Document Type:
Scientific Paper
Organization / Institution:
Roche Diagnostics GmbH
Author:
Lea Lewina, Michael Stadlmeier, Neeraj Singh, Friederike Bauland, Daniel Köppl, Alexander Gaudl, Andrea Geistanger, Uta Ceglarek, Manfred Rauch, Judith Taibon
Target Audience:
Researchers in analytical chemistry, medical diagnostics, and pharmaceutical sciences
Period of Validity:
Not specified
Date of Approval:
Not specified
Date of Revision:
Not specified
Year:
2018
Region / City:
Not specified
Subject:
Molecular Biology, DNA quantification
Document Type:
Laboratory Experiment
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Students, Researchers in Molecular Biology
Validity Period:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2021
Region / city:
Penzberg, Essen, Erlangen, Leipzig
Topic:
Analytical chemistry, steroid profiling
Document type:
Reference measurement procedure
Institution:
Roche Diagnostics GmbH
Author:
Lea Lewin, Michael Stadlmeier, Neeraj Singh, Friederike Bauland, Daniel Köppl, Alexander Gaudl, Andrea Geistanger, Uta Ceglarek, Manfred Rauh, Judith Taibon
Target audience:
Laboratory technicians, medical researchers, clinicians
Period of validity:
Ongoing
Approval date:
Not specified
Date of changes:
Not specified
Year:
2023
Region / City:
Alberta
Topic:
Greenhouse Gas Quantification
Document Type:
Report
Organization:
ERA
Author:
ERA GHG Team
Target Audience:
Applicants for ERA funding
Validity Period:
Ongoing
Approval Date:
2023
Date of Changes:
N/A
Year:
2000–2022
Study Type:
Clinical research
Patient Population:
ABL-class leukemia patients
Sample Type:
Bone marrow and blood DNA
Assay Methods:
RNA sequencing, targeted locus amplification (TLA), genomic capture high throughput sequencing (gc-HTS), Fusion Detection by Gene Enrichment (FUDGE), long-range PCR, Sanger sequencing
Quantitative Assay:
MRD Q-PCR based on genomic breakpoints and IG/TR targets
Institution:
Princess Máxima Centrum, Netherlands; USEQ sequencing facility, Utrecht, Netherlands; Macrogen Europe
Ethics:
Written informed consent obtained according to the Declaration of Helsinki
Data Tables:
Supplemental Digital Tables 1–3
Figures:
Supplemental Digital Figures 1–2
Reference Protocols:
EuroMRD guidelines
Year:
2024
Region / City:
Online
Topic:
Verification, Validation, and Uncertainty Quantification in Computational Models
Document Type:
Request Letter
Organization / Institution:
TMS
Author:
Not specified
Target Audience:
Internal organizational stakeholders
Period of Action:
August 20–22, 2024
Approval Date:
Not specified
Revision Date:
Not specified
Note:
Year
Document Type:
Claim Submission
Year:
2023
Region / City:
United Kingdom
Subject:
Fetal renal function, pregnancy
Document type:
Research article
Author:
Udoamaka Ezuruike, Alexander Blenkinsop, Amita Pansari, Khaled Abduljalil
Target audience:
Researchers, healthcare professionals, obstetricians, nephrologists
Period of action:
Pregnancy period
Date of approval:
Not provided
Date of amendments:
Not provided
Keywords:
Fetus, Pregnancy, Urine Production, Renal function, Creatinine, PBPK
Note:
Context
Year:
2024
Region / Country:
Australia
Topic:
Cardiology / Heart failure diagnostics
Document type:
Medical advisory / Medicare fact sheet
Issuing body:
Department of Health and Aged Care, Australia
Author:
Medical Services Advisory Committee (MSAC)
Target audience:
Medical practitioners, laboratories, private health insurers
Effective period:
From 1 November 2024
Approval date:
November 2023
Clinical category:
Support list (pathology)
Procedure type:
Type C
MBS item number:
66829
Fee:
$58.50
Medicare benefit:
85% = $49.75
Relevant legislation:
Health Insurance (Accredited Pathology Laboratories-Approval) Principles 2017
Year:
2018
Region / City:
Not specified
Topic:
Chemical analysis
Document type:
Scientific report
Organization / Institution:
PANalytical
Author:
Not specified
Target audience:
Scientists, researchers
Period of validity:
Not specified
Approval date:
2018-05-21
Date of amendments:
Not specified
Year:
2018
Region / City:
Not specified
Topic:
Atherosclerosis, Quantification of Aortic Lesions
Document Type:
Protocol
Organization / Institution:
Not specified
Author:
Mark Kelly LAT, Timothy P. Fitzgibbons MD PhD
Target Audience:
Laboratory Technicians, Researchers
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Equipment:
Oil red O, ImageJ software, Methanol, Syringe filter
Hazardous Conditions:
Presence of hazardous conditions warning
Year:
2026
Region / City:
Not specified
Topic:
Bariatric surgery, liver enzymes
Document type:
Research Supplementary Material
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers, medical professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Context:
A supplementary table providing quantification and allocation of inclusion indicators for abnormal elevation of liver enzymes in patients post-bariatric surgery.
Note:
Year
Year:
2023
Region / city:
Canada
Topic:
Cannabis safety, contaminants
Document type:
Research article
Organization / institution:
Health Canada
Author:
Quinton Fiering, Jordyn MacKey, Hayline Kim, Yousef Risha, Ryan Denkert, Monica Iuogovaz, Gabriela Zorila, Julia Killorn, Gayel Abi-Yaghi, Emmanuelle Bahl, Josée Verreault, Marick Gagnon, Carl Rodrigue, Roxane Arsenault, Julio Bran Barrera, Maude Lord, Jamile Ahmarani, Diana Becerra Rodriguez, Arianne Gauthier, Diana Bran Barrera, Cathy St-Laurent, Guillaume Massicotte, Roland Yang, Morgan Popplewell, Michel Blais, Peter Bradley, Cecile Le, William Mohan, André Robichaud, Catherine Deschenes, Isabelle Disnard, Geneviève Clément, Maryse Fontaine, Irène Iugovaz, Julie Bellemare, David R. Blais
Target audience:
Policymakers, regulatory bodies, researchers, public health officials
Period of validity:
2018–present
Approval date:
2023
Modification date:
Not indicated
Research Field:
Immunology
Subfield:
Host Defense and Sepsis
Experimental Model:
C57BL/6 and C57BL/6J mice
Biological Focus:
Macrophage function and bacterial clearance
Bacterial Species:
Pseudomonas aeruginosa
Laboratory Techniques:
CFU determination, ELISA, flow cytometry, Western blot, siRNA interference, fluorescence microscopy
Cell Type:
Mouse peritoneal macrophages (PMφs)
Tissues Examined:
Lung, liver, spleen, kidney
Biochemical Markers:
ALT, AST, LDH, creatinine
Cytokines and Chemokines Measured:
Prokineticin-2, TNF-α, IL-6, IL-10, IL-17A
Experimental Interventions:
rPK2 stimulation, PKR1/PKR2 siRNA transfection, macrophage depletion with clodronate liposomes
Time Points of Analysis:
24 hours and 48 hours after modeling
Detection Methods:
Hematoxylin-eosin staining, fluorescence microscopy, FACScan flow cytometry, ELISA assays
Software for Analysis:
FCM Express
Referenced Studies:
Song et al., 2016; Song et al., 2015
Animal Age:
Six- to eight-week-old mice
Year:
2026
Region / City:
Germany
Topic:
Analytical Chemistry, Isotope Dilution, Mass Spectrometry
Document Type:
Scientific Paper
Organization / Institution:
Roche Diagnostics GmbH
Author:
Lea Lewina, Michael Stadlmeier, Neeraj Singh, Friederike Bauland, Daniel Köppl, Alexander Gaudl, Andrea Geistanger, Uta Ceglarek, Manfred Rauch, Judith Taibon
Target Audience:
Researchers in analytical chemistry, medical diagnostics, and pharmaceutical sciences
Period of Validity:
Not specified
Date of Approval:
Not specified
Date of Revision:
Not specified
Year:
Not specified
Region / City:
India
Topic:
Angiogenic factors, Pregnancy complications, Fetal death
Document Type:
Research Data / Supplementary Table
Organization:
Not specified
Author:
Not specified
Target Audience:
Researchers, Medical professionals
Period of validity:
Not specified
Approval Date:
Not specified
Date of changes:
Not specified
Year:
2021
Region / city:
Penzberg, Essen, Erlangen, Leipzig
Topic:
Analytical chemistry, steroid profiling
Document type:
Reference measurement procedure
Institution:
Roche Diagnostics GmbH
Author:
Lea Lewin, Michael Stadlmeier, Neeraj Singh, Friederike Bauland, Daniel Köppl, Alexander Gaudl, Andrea Geistanger, Uta Ceglarek, Manfred Rauh, Judith Taibon
Target audience:
Laboratory technicians, medical researchers, clinicians
Period of validity:
Ongoing
Approval date:
Not specified
Date of changes:
Not specified
Year:
Not specified
Region / city:
Not specified
Subject:
Serum protein binding, small proteins
Document type:
Protocol
Organization / institution:
Not specified
Author:
Not specified
Target audience:
Researchers, scientists
Effective period:
Not specified
Approval date:
Not specified
Modification date:
Not specified