№ lp_2_1_06373
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Supplementary methodological appendix detailing statistical imputation approaches for handling missing values in untargeted MS-based metabolomics data within the KORA study.
Title:
Characterization of missingness in untargeted MS-based metabolomics data sets and evaluation of missing data handling strategies
Authors:
Kieu Trinh Do; Simone Wahl; Johannes Raffler; Sophie Molnos; Michael Laimighofer; Jerzy Adamski; Karsten Suhre; Konstantin Strauch; Annette Peters; Christian Gieger; Claudia Langenberg; Isobel D. Stewart; Fabian J. Theis; Harald Grallert; Gabi Kastenmüller; Jan Krumsiek
Type of document:
Supplementary information file
Subject:
Missing data handling strategies in untargeted MS-based metabolomics
Methods described:
Richardson & Ciampi (RC); Imputation by truncated sampling (ITS); Multiple imputation by truncated sampling (MITS); Imputation by chained equations (ICE-norm, ICE-pmm, ICE-adjR); K-nearest neighbor imputation (KNN-var, KNN-obs, KNN-obs-sel)
Software:
R
R packages:
tmvtnorm (version 1.4-9); mice (version 2.25); miceadds (version 1.5-0)
Data set:
KORA
Covariates:
Age; Sex; BMI
Statistical framework:
Maximum likelihood estimation; Bayesian linear regression; Gibbs sampling; Multiple imputation according to Rubin
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Year:
2023
Region / City:
United States
Topic:
Genomics, Genetics
Document Type:
Research Paper
Organization / Institution:
Rutgers University, NIH
Author:
Matteo Di Vincenzo, Thanavadee Prachason, Gaia Sampogna, Angelo Arias-Magnasco, Bochao Danae Lin, Lotta-Katrin Pries, Jim van Os, Bart P.F. Rutten, Ran Barzilay, Andrea Fiorillo, Sinan Guloksuz
Target Audience:
Researchers, Geneticists, Biologists
Period of Activity:
2023
Date of Approval:
N/A
Date of Changes:
N/A
Year:
2023
Region / City:
N/A
Topic:
Machine Learning, Drug Approvals, Statistical Imputation
Document Type:
Research Paper
Organization / Institution:
N/A
Author:
Andrew W. Lo, Kien Wei Siah, Chi Heem Wong
Target Audience:
Researchers, Medical and Pharmaceutical Experts
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Year:
2023
Region / city:
Global
Subject:
Climate Change, Demographic Data, Imputation Methodology
Document type:
Research methodology
Author:
World Bank
Target audience:
Researchers, Economists, Data Analysts
Period of validity:
1980-2023
Approval date:
N/A
Date of changes:
N/A
Year:
2023
Region / City:
Not specified
Subject:
Importing BMC-Compuware License File in ECC
Document Type:
Technical Guide
Organization:
BMC Software
Author:
Not specified
Target Audience:
IT professionals managing enterprise systems
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2026
Region / City:
Republic of Moldova
Subject:
Local consultancy services for management, leadership, strategic communication, and alternatives to detention
Document type:
Tender file / Terms of reference
Organization:
Council of Europe
Contract number:
BH9275/2026/1
Duration:
1 January 2025 – 31 December 2028
Submission deadline:
10 February 2026 23:59 CET
Expected start date:
02 March 2026
Number of providers:
Up to 15
Lots:
Management and leadership, Strategic communication, Systemic interventions for alternatives to detention
Estimated budget for tender:
55,000 Euros tax exclusive
Total project budget:
2,300,000 Euros
Target institutions:
General Prosecutor’s Office, Superior Council of Magistracy, Superior Council of Prosecutors, Supreme Court of Justice, National Institute of Justice, Ministry of Justice, Ministry of Internal Affairs, General Police Inspectorate, Moldovan Bar Association, Government Agent Office, Association of Women in Prosecution, Ombudsperson’s Institution/National Preventive Mechanism
Year:
2025
Region / City:
United States
Topic:
Education data management
Document Type:
Technical guide
Organization / Institution:
U.S. Department of Education
Author:
U.S. Department of Education
Target Audience:
State education agencies (SEAs), Local educational agencies (LEAs)
Effective Period:
School Year 2025-26
Approval Date:
October 2025
Date of Changes:
October 2025
Year:
2025-26
Type:
Technical guide
Publisher:
U.S. Department of Education
Contractor:
AEM Corporation
Document version:
22.0
Date of release:
October 2025
Target audience:
State education agencies and local educational agencies
Purpose:
Instructions for building and submitting EDFacts data files for N or D academic achievement
Year:
2025-26
Region / City:
United States
Topic:
Education Data Submission
Document Type:
Technical Guide
Organization / Institution:
U.S. Department of Education
Author:
Lisa Sadeghi
Target Audience:
Educational Agencies, Data Submitters
Effective Period:
SY 2025-26
Approval Date:
October 2025
Amendment Date:
October 2025
Note:
Year
Topic:
Clinical Trials
Document Type:
Plan
Target Audience:
Study team, sponsors, and regulatory authorities
Note:
Year
Subject:
Pharmaceutical manufacturing
Document Type:
Site Master File
Target Audience:
Pharmaceutical industry professionals, regulatory authorities
Date:
11/4/2025
Year:
2025
Region / City:
N/A
Topic:
BMA Lite File Templates for DTC Distribution Events
Document Type:
Reference Guide
Organization / Institution:
DTCC
Author:
N/A
Target Audience:
Agents
Effective Period:
N/A
Approval Date:
11/4/2025
Modification Date:
N/A
Year:
2024-2025
Region / City:
United States
Subject:
Education
Document Type:
Technical Guide
Organ / Institution:
U.S. Department of Education
Author:
Brandon Scott
Target Audience:
State Educational Agencies (SEAs), Local Educational Agencies (LEAs)
Period of Validity:
2024-2025
Approval Date:
June 2024
Modification Date:
July 2024, June 2025
Year:
2024-25
Region / City:
United States
Topic:
Children with Disabilities (IDEA) Suspensions and Expulsions
Document Type:
Technical Guide
Agency / Institution:
U.S. Department of Education
Author:
U.S. Department of Education
Target Audience:
State educational agencies (SEAs), local educational agencies (LEAs), school administrators
Effective Period:
2024-2025
Approval Date:
August 2024
Date of Changes:
April 2025
Year:
2025
Region / City:
Tokyo, Japan
Theme:
Conference Paper Guidelines
Document Type:
Template
Organization:
SICE FES 2025
Author:
Taro Keisoku, Hanako Seigyo
Target Audience:
Authors preparing manuscripts for SICE FES 2025
Period of Validity:
2025
Approval Date:
N/A
Modification Date:
N/A
Context:
Template for preparing final manuscripts for SICE FES 2025 conference, including formatting instructions for authors.
Year:
2024-25
Region / City:
United States
Topic:
Special Education, Data Reporting
Document Type:
Technical Guide
Organization / Institution:
U.S. Department of Education
Author:
U.S. Department of Education
Target Audience:
State educational agencies, Local educational agencies, and other educational institutions involved in data submission
Effective Period:
School Year 2024-25
Approval Date:
August 2024
Modification Date:
N/A
Year:
2024-2025
Region / City:
United States
Topic:
Education data submission
Document Type:
Technical guide
Agency / Organization:
U.S. Department of Education
Author:
Brandon Scott (Contracting Officer’s Representative)
Target Audience:
Educational agencies and administrators
Period of Validity:
SY 2024-25
Approval Date:
June 2024
Revision Date:
July 2024
Year:
2023
Region / City:
Wisconsin
Theme:
Construction, HMA Pavement, Testing Procedures
Document Type:
Test Method
Organization / Institution:
Wisconsin Department of Transportation (WisDOT)
Author:
Wisconsin Department of Transportation (WisDOT)
Target Audience:
Contractors, Engineers
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Contextual Description:
Detailed test methods and sampling procedures for HMA PWL QMP projects to ensure quality control during the paving process.
Supplementary material for radiomic analysis of MRI sequences using various machine learning methods
Year:
2023
Region / city:
Not specified
Theme:
Radiomics, MRI sequences, machine learning
Document type:
Research Supplement
Author:
Not specified
Target audience:
Researchers, medical professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified