№ files_lp_4_process_3_059311
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The document describes methods for pre-processing data and handling missing data in the context of using machine learning to predict drug approvals based on clinical trials and pharmaceutical databases.
Year:
2023
Region / City:
N/A
Topic:
Machine Learning, Drug Approvals, Statistical Imputation
Document Type:
Research Paper
Organization / Institution:
N/A
Author:
Andrew W. Lo, Kien Wei Siah, Chi Heem Wong
Target Audience:
Researchers, Medical and Pharmaceutical Experts
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
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Title:
Characterization of missingness in untargeted MS-based metabolomics data sets and evaluation of missing data handling strategies
Authors:
Kieu Trinh Do; Simone Wahl; Johannes Raffler; Sophie Molnos; Michael Laimighofer; Jerzy Adamski; Karsten Suhre; Konstantin Strauch; Annette Peters; Christian Gieger; Claudia Langenberg; Isobel D. Stewart; Fabian J. Theis; Harald Grallert; Gabi Kastenmüller; Jan Krumsiek
Type of document:
Supplementary information file
Subject:
Missing data handling strategies in untargeted MS-based metabolomics
Methods described:
Richardson & Ciampi (RC); Imputation by truncated sampling (ITS); Multiple imputation by truncated sampling (MITS); Imputation by chained equations (ICE-norm, ICE-pmm, ICE-adjR); K-nearest neighbor imputation (KNN-var, KNN-obs, KNN-obs-sel)
Software:
R
R packages:
tmvtnorm (version 1.4-9); mice (version 2.25); miceadds (version 1.5-0)
Data set:
KORA
Covariates:
Age; Sex; BMI
Statistical framework:
Maximum likelihood estimation; Bayesian linear regression; Gibbs sampling; Multiple imputation according to Rubin
Year:
2023
Region / City:
United States
Topic:
Genomics, Genetics
Document Type:
Research Paper
Organization / Institution:
Rutgers University, NIH
Author:
Matteo Di Vincenzo, Thanavadee Prachason, Gaia Sampogna, Angelo Arias-Magnasco, Bochao Danae Lin, Lotta-Katrin Pries, Jim van Os, Bart P.F. Rutten, Ran Barzilay, Andrea Fiorillo, Sinan Guloksuz
Target Audience:
Researchers, Geneticists, Biologists
Period of Activity:
2023
Date of Approval:
N/A
Date of Changes:
N/A
Year:
2023
Region / city:
Global
Subject:
Climate Change, Demographic Data, Imputation Methodology
Document type:
Research methodology
Author:
World Bank
Target audience:
Researchers, Economists, Data Analysts
Period of validity:
1980-2023
Approval date:
N/A
Date of changes:
N/A
Year:
2020
Region / City:
Bowdoinham, Maine
Subject:
Development, Urban Planning
Document Type:
Research Paper
Organization / Institution:
Bowdoinham Town Government
Author:
Rodger Heidgerken
Target Audience:
Local Government Officials, Urban Planners
Period of Validity:
2011-2024
Approval Date:
N/A
Modification Date:
N/A
Note:
Year
Author:
Andreas Fønss Møller, Kedar Nath Natarajan
Year:
2026
Region / City:
N/A
Topic:
Astronomy
Document Type:
Educational Material
Organization / Institution:
N/A
Author:
N/A
Target Audience:
Students, Educators
Period of Action:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2023
Region / City:
Wuhan, China
Topic:
Immunology, Cancer Research, Gene Expression, Immunotherapy
Document Type:
Research Article
Institution:
Wuhan University of Science & Technology, Huazhong University of Science and Technology, Anhui Normal University
Authors:
Fei-Fei Hu, Chun-Jie Liu, Lan-Lan Liu, Qiong Zhang, An-Yuan Guo
Target Audience:
Researchers, Healthcare Professionals, Academics in Immunology and Oncology
Period of Validity:
N/A
Approval Date:
N/A
Date of Last Revision:
N/A
Year:
2023
Region / City:
N/A
Topic:
Drug repurposing, machine learning models
Document Type:
Research article
Organization / Institution:
N/A
Author:
N/A
Target Audience:
Researchers, Data Scientists
Effective Period:
N/A
Approval Date:
N/A
Modification Date:
N/A
Description of Document:
A research article comparing the performance of different machine learning models in predicting drug-disease approval likelihood using various optimization techniques and cross-validation methods.
Year:
2026
Region / City:
Global
Topic:
Supply chain, Data analytics, Machine learning, Risk prediction
Document type:
Research paper
Organization:
OEM
Author:
Unknown
Target audience:
Researchers, supply chain professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Year:
2022
Region / City:
Mafraq, Jordan
Subject:
Atmospheric Science / Meteorology
Document Type:
Laboratory Experiment Report
Institution:
Meteorology Department / Mafraq Station
Author:
Not specified
Target Audience:
Students and researchers in meteorology
Observation Date:
24 March 2022
Station Identifier:
OJMF (WMO 40265)
Latitude:
32.37
Longitude:
36.25
Elevation:
687 m
Measured Variables:
Pressure, Temperature, Dew Point, Mixing Ratio, Saturation Mixing Ratio, Relative Humidity
Procedure Reference:
Skew-T/log-P thermodynamic diagram method
Data Table Included:
Yes
Year:
Not specified
Region / city:
Not specified
Theme:
Chemistry, Chemical Reactions
Document type:
Educational Material
Author:
Not specified
Target audience:
Students, Chemistry learners
Period of validity:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Context:
A chemistry guide explaining the rules for predicting products in various types of chemical reactions.
Year:
2023
Region / City:
Not specified
Subject:
Linguistic Features, Eye Movement
Document Type:
Research Supplement
Organization / Institution:
Not specified
Author:
Shingo Nahatame
Target Audience:
Researchers in linguistics and psycholinguistics
Period of Validity:
Not specified
Date of Approval:
Not specified
Date of Changes:
Not specified
Year:
2022
Field:
Vascular Surgery; Rehabilitation Medicine
Topic:
Prosthetic Mobility and Functional Outcomes After Major Lower Limb Amputation
Document Type:
Scientific Research Article
Manuscript Category:
Original Article
Authors:
Arsalan Wafi; Luis Ribeiro; Vijay Kolli; Bilal Azhar; James Budge; Ian M. Loftus; Peter J. E. Holt
Institutions:
St George’s Vascular Institute, St George’s University Hospital, London, United Kingdom; Douglas Bader Rehabilitation Unit, Queen Mary’s Hospital, London, United Kingdom
Study Design:
Retrospective Cohort Study of a Prospectively Maintained Database
Study Period:
2007–2020
Follow-up End Date:
April 2021
Population:
Patients with unilateral major lower limb amputation due to advanced ischaemia or diabetic foot disease
Sample Size:
771 Patients
Clinical Conditions Studied:
Acute Limb Ischaemia; Chronic Limb-Threatening Ischaemia; Peripheral Arterial Disease; Diabetic Foot Disease
Outcome Measure:
Independent Prosthetic Mobility After Rehabilitation
Secondary Outcome:
Association Between Prosthetic Mobility and Long-Term Survival
Presentation Event:
Veith Symposium, New York, 2022
Keywords:
Amputation; Prosthetic Mobility; Rehabilitation; Functional Outcome; Survival; Gender Differences
Conflicts of Interest:
None
Year:
2023
Region / City:
Padova, Italy
Topic:
Pharmaceutical Development, Drug Solubility
Document Type:
Research Study
Organization / Institution:
University of Padova, GlaxoSmithKline
Author:
Marco Brendolan, Francesca Cenci, Konstantinos Stamatopoulos, Fabrizio Bezzo, Pierantonio Facco
Target Audience:
Pharmaceutical Researchers, Bioengineers
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2020-2021
Region / Institution:
University of York, UK; Human Connectome Project (HCP), USA
Subjects:
Healthy adults, right-handed, native English speakers
Methodology:
MRI acquisition, fMRI tasks (auditory and visual), image preprocessing
Data Type:
Structural and functional neuroimaging
Authors:
Xiuyi Wang, Katya Krieger-Redwood, Meichao Zhang, Zaixu Cui, Xiaokang Wang, Theodoros Karapanagiotidis, Yi Du, Robert Leech, Boris Bernhardt, Daniel Margulies, Jonathan Smallwood, Elizabeth Jefferies
Ethics Approval:
York Neuroimaging Centre and Department of Psychology ethics committees
Tasks:
Auditory story, math, visual language, math, spatial judgments
Scanner:
Siemens 3T (Connectome and Prisma)
Processing Pipelines:
HCP minimal preprocessing, fMRIPrep 20.2.1, FreeSurfer, ANTs, FSL
Data Exclusion:
Incomplete sessions, low accuracy participants
Endnote:
Multimodal surface matching, spatial normalization to MNI templates
Year:
2012–2022
Region / City:
Kolkata, India
Country:
India
Field:
Oncology; Gastrointestinal Pathology
Topic:
Prognostic significance of tumor size and staging in ampullary adenocarcinoma
Document Type:
Scientific research article
Institution:
Tata Medical Center, Kolkata; Vanderbilt University Medical Center, Tennessee
Authors:
Paromita Roy; Pritam Ray; Rohit Tapadia; Sudeep Banerjee; Indranil Mallick; Deyali Chatterjee
Corresponding Author:
Paromita Roy
Affiliation of Corresponding Author:
Department of Pathology, Tata Medical Center, Kolkata, India
Study Design:
Retrospective clinicopathologic study
Study Population:
Patients with ampullary adenocarcinoma who underwent surgery with curative intent
Study Period:
June 2012 – June 2022
Number of Cases Analyzed:
146
Medical Procedure Context:
Whipple resection specimen evaluation
Key Variables:
Tumor size; AJCC TNM staging; disease-free survival; overall survival; perineural invasion; surgical margin status; nodal status
Ethics Approval:
Institutional review board consent waiver (EC/WV/TMC/18/23)
Keywords:
Ampulla; tumour size; survival; Whipple; AJCC; TNM; periampullary pathology
Year:
2025
Region / City:
Saitama, Japan
Topic:
Neurosurgery, Moyamoya Disease, Revascularization
Document Type:
Research Article
Organization / Institution:
Saitama Medical University International Medical Center
Author:
Koki Onodera, Akio Teranishi, Yushiro Take, Omar F. Jbarah, Hiroki Kurita
Target Audience:
Medical professionals, researchers, healthcare institutions
Period of Action:
April 2021 - March 2025
Date of Approval:
2025
Date of Changes:
N/A
Year:
2026
Region / City:
Delmarva Peninsula
Topic:
Agricultural Losses, Extreme Weather, Machine Learning
Document Type:
Research Paper
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, Agricultural Experts, Climate Scientists
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2023
Region / city:
European Union
Theme:
Aviation, Maintenance, Training
Document type:
User Guide
Organisation:
European Aviation Safety Agency (EASA)
Author:
Omar Elkhartoufi
Target audience:
Applicants and approval holders of EASA Part 147 organisations outside the EU
Period of validity:
Not specified
Approval date:
15/11/2023
Date of changes:
15/11/2023
Year:
2025
Region / City:
Hilo, Hawai‘i
Topic:
Legislative Approvals, Public Testimony, Land Acquisition
Document Type:
Notice
Organization / Institution:
Hawai‘i County Council
Author:
Hawai‘i County Council
Target Audience:
Public, Council Members, Stakeholders in Land Use and Public Policy
Period of Action:
September 2, 2025
Approval Date:
September 2, 2025
Amendment Date:
N/A