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Official committee record documenting discussions, attendance, and declared interests from a Diagnostics Advisory Committee meeting on the evaluation of MRI-based technologies for non-alcoholic fatty liver disease within a national health technology assessment process.
Organization:
National Institute for Health and Care Excellence
Centre:
Centre for Health Technology Evaluation
Committee:
Diagnostics Advisory Committee
Document type:
Meeting minutes
Meeting date:
28 September 2022
Location:
Via Zoom
Session type:
Open session
Chair:
Brian Shine
Topic:
Evaluation of MRI-based technologies for assessing non-alcoholic fatty liver disease
Participants:
Committee members, NICE staff, external assessment groups, external assessment centres, specialist committee members, experts, observers
Conflicts of interest:
Declarations recorded
Approval status:
Minutes confirmed
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Name:
Mr Wong
Age:
45
Gender:
Male
Diagnosis:
Non-Alcoholic Fatty Liver Disease (NAFLD)
Occupation:
Software Developer
Document Type:
Clinical interview and dietary assessment report
Medical Condition:
Non-Alcoholic Fatty Liver Disease
Assessment Focus:
Dietary habits and lifestyle changes
Pre-Diagnosis Diet Characteristics:
High intake of refined carbohydrates, sugars, saturated and trans fats; frequent sugary drinks and alcohol consumption
Post-Diagnosis Diet Characteristics:
Increased intake of whole grains, lean proteins, healthy fats, and fibre; reduced refined sugars, saturated fats, sugary drinks, and alcohol
Lifestyle Factors:
Physical activity and weight management
Recommendations:
Dietary modification, increased omega-3 intake, portion control, increased physical activity
Plan:
Follow-up appointments, dietitian referral, educational materials, personalized exercise plan
Includes:
Patient reflection statement
Approval report – Application A1180 Natural Glycolipids as a preservative in non-alcoholic beverages
Year:
2020
Region / city:
Australia / New Zealand
Topic:
Food standards, preservatives
Document type:
Approval report
Organization:
Food Standards Australia New Zealand (FSANZ)
Author:
FSANZ
Target audience:
Regulatory bodies, food industry stakeholders
Period of validity:
Not specified
Approval date:
1 December 2020
Amendment date:
6 August 2020
Document reference number:
145-20
Authors:
Petar Avramovski; Julijana Petrovska; Maja Avramovska
Affiliations:
St. Clement of Ohrid University – Bitola; Clinical Hospital – Bitola
Country:
North Macedonia
City:
Bitola
Medical Field:
Gastroenterology; Hepatology; Diagnostic Ultrasound
Type of Document:
Scientific research abstract
Study Design:
Observational clinical study
Study Population:
325 patients with non-alcoholic fatty liver disease (NAFLD)
Average Age of Participants:
54.2±8.5 years
Institutions Involved:
Department of Ultrasonography; Department of Gastroenterohepatology; Department of Gynecology and Obstetrics, Clinical Hospital – Bitola
Methods:
B-mode ultrasound imaging, echogenicity analysis software, laboratory tests for platelets, ALT and AST, calculation of FIB-4 score
Diagnostic Indicators Studied:
Hepatorenal Index (HRI); Fibrosis-4 (FIB-4) score
Conditions Examined:
Non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; liver fibrosis; cirrhosis
Patient Group Classification:
Mild NAFLD; moderate NAFLD; severe NAFLD; significant fibrosis (≥F2); advanced fibrosis (≥F3); cirrhosis (F4)
Keywords:
hepatorenal index; FIB-4 score; NAFLD; liver fibrosis; cirrhosis; ultrasound diagnostics
Year:
2021
Region / City:
Australia / New Zealand
Subject:
Food Additives
Document Type:
Risk Assessment
Organization / Institution:
FSANZ
Author:
FSANZ
Target Audience:
Food Safety Authorities, Researchers, Food Industry
Period of Validity:
Not specified
Approval Date:
9 February 2021
Amendment Date:
Not specified
Year:
2022
Region / city:
Nanjing
Topic:
Hepatocellular Carcinoma, Gut Microbiota, Immunology
Document type:
Supplementary Materials
Organization / institution:
Nanjing Medical University
Author:
Chupeng Hu, Bingqing Xu, Yun Chen
Target audience:
Researchers, scientists, medical professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Name:
Mr Wong
Age:
45
Gender:
Male
Diagnosis:
Non-Alcoholic Fatty Liver Disease (NAFLD)
Occupation:
Software Developer
Document Type:
Clinical interview and dietary assessment report
Medical Condition:
Non-Alcoholic Fatty Liver Disease
Assessment Focus:
Dietary habits and lifestyle changes
Pre-Diagnosis Diet Characteristics:
High intake of refined carbohydrates, sugars, saturated and trans fats; frequent sugary drinks and alcohol consumption
Post-Diagnosis Diet Characteristics:
Increased intake of whole grains, lean proteins, healthy fats, and fibre; reduced refined sugars, saturated fats, sugary drinks, and alcohol
Lifestyle Factors:
Physical activity and weight management
Recommendations:
Dietary modification, increased omega-3 intake, portion control, increased physical activity
Plan:
Follow-up appointments, dietitian referral, educational materials, personalized exercise plan
Includes:
Patient reflection statement
Year:
2010-2024
Region / city:
Asia-Pacific
Subject:
Hepatology
Document Type:
Clinical Practice Guidelines
Organization / Institution:
Asian Pacific Association for the Study of the Liver (APASL)
Author:
APASL
Target Audience:
Healthcare professionals
Period of validity:
2010-2024
Date of approval:
2010
Date of revisions:
2024
Context:
Collection of clinical practice guidelines and consensus statements issued by the Asian Pacific Association for the Study of the Liver on various hepatological conditions, including hepatocellular carcinoma, hepatitis B and C, liver transplantation, and metabolic diseases.
Organisations:
European Society for Paediatric Gastroenterology Hepatology and Nutrition; European Association for the Study of the Liver
Type of document:
Joint statement
Thematic area:
Paediatric hepatology; fatty liver disease; NAFLD; MAFLD
Subject:
Diagnostic approach to hepatic steatosis in children and adolescents
Target audience:
Paediatricians; hepatologists; clinicians
Geographical scope:
Europe
Key terms:
Non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); insulin resistance; metabolic syndrome; Wilson’s disease; autoimmune hepatitis
Referenced process:
Global multi-stakeholder Delphi consensus on nomenclature and definition of fatty liver disease
Correspondence:
[email protected]
Year:
NA
Region / City:
Mumbai
Topic:
Safety Data Sheet
Document Type:
Material Safety Data Sheet
Organization:
Pranav Agro
Author:
NA
Target Audience:
NA
Effective Period:
NA
Approval Date:
NA
Date of Changes:
NA
Year:
2021
Region / City:
Americas, Europe
Subject:
Oleochemical Industry, Catalysts
Document Type:
Technical Paper
Organization / Institution:
Evonik Industries
Author:
Evonik Catalysts Team
Target Audience:
Professionals in oleochemical manufacturing, researchers in catalysis
Period of Effect:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Organization:
International Society for the Study of Fatty Acids and Lipids (ISSFAL)
Document type:
Official statement
Statement number:
5
Topic:
Alpha-linolenic acid supplementation and conversion to n-3 long chain polyunsaturated fatty acids
Subject area:
PUFA nutrition
Authors:
J. Thomas Brenna; Norman Salem, Jr.; Andrew J. Sinclair; Stephen C. Cunnane
Affiliations:
Division of Nutritional Sciences, Cornell University; Martek Biosciences, Inc.; Deakin University, School of Exercise & Nutrition Sciences; Research Center on Aging, Université de Sherbrooke
Approval body:
ISSFAL Board of Directors
Geographical scope:
International
Population focus:
Humans and mammals, including infants and adults
Key substances:
Alpha-linolenic acid (ALA); Eicosapentaenoic acid (EPA); Docosapentaenoic acid (DPA); Docosahexaenoic acid (DHA); Linoleic acid (LA)
Type of evidence:
In vivo metabolic studies; tracer studies with stable isotopes; animal tissue compositional studies; human blood and breast milk analyses
Dietary context:
Western diets rich in linoleic acid
Document type:
Supplementary tables to a scientific research article
Subject:
Nutritional composition and physiological effects of nano-selenium in on-growing grass carp
Study organism:
On-growing grass carp
Experimental groups:
RD; HFD; HSe0.3; HSe0.6
Dietary treatments:
Regular diet; high-fat diet; high-fat diet supplemented with 0.3 mg/kg nano-Se; high-fat diet supplemented with 0.6 mg/kg nano-Se
Measured parameters:
Growth performance; gene expression primers; fatty acid composition of muscle
Nutrients analyzed:
Crude protein; crude lipid; selenium levels; fatty acids (SFA, MUFA, PUFA, n-3 PUFA, n-6 PUFA)
Genes analyzed:
β-actin; MyoD; MyoG; PPARα; ATGL; LPL; HSL; PI3K; AKT; TOR; S6K1; 4E-BP1; GLDH
Data presentation:
Mean ± SD (n = 3); statistical significance at P < 0.05
Language:
English
Authors:
Petar Avramovski; Julijana Petrovska; Maja Avramovska
Affiliations:
St. Clement of Ohrid University – Bitola; Clinical Hospital – Bitola
Country:
North Macedonia
City:
Bitola
Medical Field:
Gastroenterology; Hepatology; Diagnostic Ultrasound
Type of Document:
Scientific research abstract
Study Design:
Observational clinical study
Study Population:
325 patients with non-alcoholic fatty liver disease (NAFLD)
Average Age of Participants:
54.2±8.5 years
Institutions Involved:
Department of Ultrasonography; Department of Gastroenterohepatology; Department of Gynecology and Obstetrics, Clinical Hospital – Bitola
Methods:
B-mode ultrasound imaging, echogenicity analysis software, laboratory tests for platelets, ALT and AST, calculation of FIB-4 score
Diagnostic Indicators Studied:
Hepatorenal Index (HRI); Fibrosis-4 (FIB-4) score
Conditions Examined:
Non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; liver fibrosis; cirrhosis
Patient Group Classification:
Mild NAFLD; moderate NAFLD; severe NAFLD; significant fibrosis (≥F2); advanced fibrosis (≥F3); cirrhosis (F4)
Keywords:
hepatorenal index; FIB-4 score; NAFLD; liver fibrosis; cirrhosis; ultrasound diagnostics
Year:
1930s
Region / City:
Northern Canada
Subject:
Indigenous Residential School Experiences
Document Type:
Book Excerpt
Author:
Christy Jordan-Fenton and Margaret Pokiak-Fenton
Target Audience:
Young adults
Main Character:
Olemaun
Setting:
Home community and residential school
Themes:
Cultural clash, family decisions, childhood curiosity, adaptation to school rules
Historical Context:
Residential schools in Canada
Year:
2023
Region / City:
United States
Topic:
Non-alcoholic fatty liver disease, Ethylene oxide exposure
Document Type:
Research Supplement
Author:
Shiwei Yan, Haolong Pei, Qian Li, Wenzhe Cao, Yan Dou, Shihan Zhen, Qingyao Wu, Fengchao Liang
Target Audience:
Researchers, Public Health Professionals
Period of Validity:
2013-2018
Approval Date:
Not specified
Date of Changes:
Not specified
Name of medicinal product:
FORTALINE® PLUS Omega 3 fatty acids – vitamin E
Strength:
500 mg marine lipid concentrate (18% EPA, 12% DHA) – 10 mg vitamin E
Pharmaceutical form:
Soft capsule
Composition:
Marine lipid concentrate (fish oil) and α-tocopheryl acetate (vitamin E)
Active substances:
Omega-3 fatty acids (EPA, DHA), Vitamin E
Technology:
EnteriCare™ Anti-Reflux Technology
ATC code:
C10AX06; A11HA03
Pharmacotherapeutic group:
Other lipid modifying agents; Other plain vitamins
Route of administration:
Oral use
Recommended dosage (adults):
One to two capsules per day
Recommended dosage (pregnant and lactating women):
Two to three capsules per day
Recommended dosage (children able to swallow capsules):
One capsule per day
Therapeutic indications:
Dietary supplementation with omega-3 fatty acids for nutritional balance and physiological support
Contraindications:
Hypersensitivity to ingredients; concomitant use with aspirin or anticoagulants such as warfarin; patients at high risk of bleeding
Adverse reactions:
Gastrointestinal disorders, nausea, dyspepsia, rash, bruising, belching, diarrhoea, heartburn, bad breath
Pharmacological components:
Eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), Vitamin E
Target populations:
Adults, pregnant and lactating women, children able to swallow capsules
Document type:
Medicinal product summary of characteristics
Field:
Pharmacology / dietary supplementation
Year:
2026
Region / City:
Berkshires, New York City
Topic:
Nutrition, Essential Fatty Acids, Microbiome
Document Type:
Podcast Transcript
Organization / Institution:
The Health Edge
Speakers:
Mark [host], Dr. John Bagnulo
Audience:
General public interested in health and nutrition
Event:
Integrative Health Symposium
Date of Recording:
March 2026
Key Subjects:
Omega-3, Omega-6, Glyphosates, Inflammation, Microbiome
Scientific Focus:
Dietary fats, hormone production, eicosanoids