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A peer-reviewed scientific review examining the biological mechanisms, technological platforms, and clinical uses of liquid biopsy for detecting circulating tumour biomarkers in multiple body fluids and its role in precision oncology.
Year:
2024
Field:
Oncology, Precision Medicine
Document type:
Review article
Authors:
Bore et al.
Keywords:
ctDNA, CTCs, Extracellular vesicles, Liquid biopsy, Tumour-educated platelets, Precision oncology
Intended audience:
Medical researchers, clinicians
Biological materials analyzed:
Blood, urine, saliva, cerebrospinal fluid, semen
Technologies discussed:
Next-generation sequencing, digital PCR, microfluidic CTC capture
Clinical applications:
Cancer diagnosis, prognosis, treatment monitoring, detection of therapy resistance
Research trends:
Peak in scientific publications in 2024
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2021
Region / City:
Pirassununga, SP, Brazil
Topic:
Veterinary medicine, animal welfare, swine castration
Document Type:
Research article
Institution:
University of Sao Paulo, North Carolina State University, Washington State University, Michigan State University, Iowa State University, University of Missouri
Author:
Laya Kannan Silva Alves, Monique Danielle Pairis-Garcia, Juliana Bonin Ferreira, Victoria Rocha Merenda, Rubia Mitalli Tomacheski, Pedro Henrique Esteves Trindade, Christopher Siepker, Magdiel Lopez-Soriano
Target Audience:
Researchers, veterinary professionals
Period of Study:
Not specified
Approval Date:
Not specified
Date of Revision:
Not specified
Year:
2025
Region / city:
Victoria
Subject:
Cancer biomarkers
Document type:
Regulatory document
Organization / institution:
Department of Health
Author:
Unknown
Target audience:
Healthcare professionals, pathology laboratories
Effective date:
18 September 2025
Date of approval:
Unknown
Date of amendments:
Unknown
Year:
2023
Program:
Lysosomal Biomarkers Program
Document Type:
Pre-Proposal Template
Intended Audience:
Principal Investigators and Research Teams
Submission Format:
PDF
Institution/Company:
[To be filled by applicant]
Principal Investigator:
[To be filled by applicant]
Project Focus:
Biomarker development, characterization, or validation
Target Disease:
Parkinson’s Disease
Scope:
Experimental plan including rationale, study design, and resource availability
Inclusion Considerations:
Diversity, equity, and inclusion in sample selection
Authors:
Joshua B. Ewen; Claudio Babiloni; Gary S. Collins; Lauren E. Ethridge; Jean Gotman; Akio Ikeda; Philippa J. Karoly; William Z. Potter; Stephan Rampp; Margitta Seeck; Sándor Beniczky
Submitting body:
IFCN Executive Committee
Submission date:
15 July 2024
Organ / Institution:
International Federation of Clinical Neurophysiology (IFCN)
Document type:
Reporting guideline; Explanation and Elaboration document
Field:
Clinical neurophysiology; EEG-based biomarkers
Scope:
Evaluation and reporting of clinical biomarker accuracy studies involving EEG technologies
Related frameworks:
STARD; TRIPOD; EQUATOR Network
Intended use:
Reporting standards across biomarker validation phases (Phase 1–3)
Contexts of Use:
Diagnostic; Monitoring; Response; Predictive; Prognostic; Safety; Susceptibility/Risk
Validation phases described:
Phase 1 (Discovery); Phase 2 (Preliminary validation); Phase 3 (Validation)
Year:
2019
Region / City:
Boston, MA, USA
Topic:
Biomarkers, therapeutic development, clinical trials
Document type:
Article
Organization / Institution:
Harvard Business School, Harvard-MIT Center for Regulatory Science
Author:
Ariel Dora Stern
Target Audience:
Researchers, regulators, the therapeutics industry
Period of validity:
N/A
Approval Date:
May 22, 2019
Funding:
Kauffman Foundation
Running title:
Biomarker ratios for personalized therapeutic decisions
Authors:
Dejana Bajić; Nemanja Todorović; Mladena Lalić Popović; Ljiljana Andrijević
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Novi Sad; Department of Pharmacy, Faculty of Medicine, University of Novi Sad
Institution:
Institute for Pulmonary Diseases of Vojvodina, Clinic for Intensive Medicine and Vascular Pulmonary Diseases, Department for Intensive Care and Intoxications Level 3
Country:
Serbia
Corresponding author:
Dejana Bajić, MD, PhD
ORCID IDs:
0000-0002-7958-068X; 0000-0002-1519-5643; 0000-0001-8354-3868; 0000-003-0676-7985
Study design:
Retrospective observational clinical study
Study period:
November 2020 – February 2022
Sample size:
133 ICU patients with COVID-19-related sepsis
Primary endpoint:
28-day mortality
Biomarkers analyzed:
Neutrophil-to-lymphocyte ratio (NLR); Fibrinogen-to-albumin ratio (FAR); C-reactive protein-to-albumin ratio (CAR)
Statistical methods:
ROC curve analysis; logistic regression
Ethical approval:
Ethics Committee of the Institute for Pulmonary Diseases of Vojvodina (Protocol Code No. 9-II/3, February 24, 2022); Ethics Committee of the Faculty of Medicine, University of Novi Sad (Protocol Code No. 01-39/190/1)
Conflicts of interest:
None declared
Funding:
No financial support received
Keywords:
biomarkers; COVID-19; inflammation; prognosis
Year:
2026
Region / City:
Ulm, Germany
Theme:
Blood biomarkers, Frailty, Geriatrics
Document Type:
Research Study
Institution:
Ulm University Medical Centre
Author:
Felix Boehm MSc, Lea Fritzenschaft, MD, Stefanie Braig, Michael Denkinger, MD, Dietrich Rothenbacher, MD, Dhayana Dallmeier, MD
Target Audience:
Researchers, Healthcare professionals, Geriatric specialists
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2026
Region / City:
Beijing
Topic:
Biomarkers, Environmental Science
Document Type:
Research Supplement
Institution:
Peking University
Authors:
Fanrong Zhao, Qiyue Kang, Xiaohua Zhang, Jiaying Liu, Jianying Hu
Target Audience:
Researchers in environmental sciences, toxicology
Period of Validity:
N/A
Approval Date:
N/A
Date of Last Update:
N/A
Contextual Description:
Research supplement detailing the synthesis and analysis of biomarkers for human exposure to flame retardants.
Year:
2023
Region / City:
Europe
Field:
Biomarkers, Clinical Research
Document Type:
Guidelines
Organization:
BioMS-eu
Author:
Michael Khalil
Target Audience:
Researchers, Clinical Laboratories
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Modifications:
Not specified
Context:
This document outlines the procedures and requirements for collaboration in research studies related to biomarkers within the BIOMS-eu network.
Year:
2024
Region / City:
New Zealand
Topic:
Medical research, concussion biomarkers
Document Type:
Consent form
Institution:
Health and Disability Ethics Committee, New Zealand
Principal Investigator:
Professor Patria Hume
Co-Investigators:
Dr Ed Maunder, Professor Alice Theadom, Dr Beth McQuiston, Dr Chris Puliu’vea, Dr Doug King, Dr Stephen Kara, Assoc Prof Mangor Pedersen, Dr Liza Kunz, et al.
Target Audience:
Female research participants
Study Period:
November 2024 – March 2025
Ethics Approval Date:
March 2025
Ethics Reference Number:
HDEC 2024 EXP 21888
Trial Registry:
ANZCTR ACTRN12625000260426
Consent Type:
Informed voluntary participation with options for data use and future contact
Year:
2026
Region / City:
Baltimore, MD, USA; Research Triangle Park, NC, USA; Durham, NC, USA; Chapel Hill, NC, USA
Subject:
Environmental health; Biomonitoring; Heavy metals
Document Type:
Supplementary material
Institution:
Johns Hopkins Bloomberg School of Public Health; National Institute of Environmental Health Sciences; Social & Scientific Systems, Inc.; University of North Carolina Gillings School of Global Public Health
Authors:
Joyce J.Y. Lin, Lily J. Koffman, Mina W. Tehrani, Rui Chen, Dale P. Sandler, Kaitlyn G. Lawrence, W. Braxton Jackson II, Aisha S. Dickerson, Gurumurthy Ramachandran, Lawrence S. Engel, Ana M. Rule
Study Population:
Adult participants aged 20–69, racially diverse
Data Collection Period:
Not specified
Analytical Methods:
ICP-MS gas modes for elemental analysis, log10 transformation, Shapiro-Wilk test for normality
Measured Elements:
Al, Cd, Cu, Fe, Mg, Mn, Pb, Sb, V, Zn, As, Ca, Cr, Ni, Se, Co, Hg, Mo
Sample Type:
Toenail clippings
Figures and Tables:
Distributions of metal concentrations, sub-sample agreement scatterplots, density plots comparing elemental concentrations
Year:
2021
Region / City:
International
Topic:
Soft tissue sarcoma histopathology
Document Type:
Guide
Organization / Institution:
International Collaboration on Cancer Reporting (ICCR)
Author:
Not specified
Target Audience:
Pathologists, oncologists, medical professionals
Effective Period:
Ongoing
Approval Date:
Not specified
Amendment Date:
Not specified
Version:
1.2.0.0
Protocol posting date:
March 2023
Document type:
Clinical pathology protocol
Medical field:
Breast pathology, oncology
Procedures covered:
Needle biopsy, fine needle aspiration, other biopsy procedures
Tumor types included:
Invasive breast carcinoma of any type, with or without ductal carcinoma in situ
Tumor types excluded:
Ductal carcinoma in situ without invasion, Paget disease without invasion, phyllodes tumor, lymphoma, sarcoma
Authors:
Patrick L. Fitzgibbons, MD, FCAP; James L. Connolly, MD
Organization:
College of American Pathologists
Accreditation status:
Recommended for clinical care, not required for accreditation
Intended use:
Reporting of biopsy specimens
Updates:
Optional reporting of largest invasive focus; revised lymphatic and/or vascular invasion terminology
Note:
Year
Theme:
Neuropathology, Biopsy, Medical Guidelines
Document Type:
Guidelines
Organization / Institution:
Southmead Hospital
Target Audience:
Medical professionals, Neuropathologists
Context:
Guidelines for handling and sending nerve biopsy specimens to the Neuropathology Department for analysis and further processing.
Note:
Year
Subject:
Neuropathology, Prion Diseases
Document Type:
Procedure
Organization / Institution:
National Prion Disease Pathology Surveillance Center
Author:
Chad Patete for Dr. Gambetti
Target Audience:
Neuropathologists, Medical Staff
Version:
4.2.0.0
Protocol Posting Date:
June 2024
Year:
2024
Region / city:
Not specified
Topic:
Bone tumor biopsy protocols
Document type:
Protocol
Organization / institution:
Not specified
Author:
Paari Murugan, MD, FCAP; Julie C. Fanburg-Smith, MD, FCAP; Andrew Horvai, MD, PhD; Fernanda Amary, MD, PhD; Meera Hameed, MD, FCAP; Michael J. Klein, MD
Target audience:
Clinicians and pathologists involved in biopsy procedures for bone tumors
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Year:
2017
Region / City:
Miami, Florida
Subject:
Procurement of Medical Equipment
Document Type:
Combined Synopsis/Solicitation
Agency:
Department of Veterans Affairs
Author:
Department of Veterans Affairs
Target Audience:
Service Disabled/Veteran Owned Small Businesses
Period of Effectiveness:
From January 19, 2017
Approval Date:
January 19, 2017
Modification Date:
N/A
Note:
Year
Topic:
Medical Procedure
Document Type:
Educational Material and Consent Form
Target Audience:
Patients undergoing vulvar biopsy
Contextual description:
Document providing detailed information and consent form for patients undergoing vulvar biopsy, including risks, procedure details, and alternatives.