№ lp_2_1_27466
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This article discusses the role of tranexamic acid in reducing maternal deaths caused by post-partum haemorrhage, particularly in resource-poor settings, following the results of the World Maternal Antifibrinolytic (WOMAN) trial.
Year:
2016
Region / city:
Global
Topic:
Maternal health, Post-partum haemorrhage
Document type:
Research review
Organization / institution:
British Journal of Haematology, St Bartholomew’s Hospital, London School of Hygiene and Tropical Medicine
Author:
Stephen P Hibbs, Ian Roberts, Haleema Shakur-Still, Beverley J Hunt
Target audience:
Healthcare professionals, researchers, policymakers
Period of validity:
Ongoing
Approval date:
Not specified
Date of revisions:
Not specified
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Year:
2024
Region / city:
Australia
Topic:
Medical Research, Stroke, Cerebral Amyloid Angiopathy, Clinical Trial
Document Type:
Participant Information Sheet / Consent Form
Organization / institution:
Alfred Health
Author:
Dr. Oshi Swarup, Prof Geoffrey Cloud, Prof Nawaf Yassi
Target Audience:
Adults with Cerebral Amyloid Angiopathy
Period of Action:
26 weeks
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2025
Region / City:
UK
Topic:
Healthcare, Medication Guidelines
Document Type:
Medical Protocol
Organisation:
National Ambulance Service Medical Directors (NASMeD)
Author:
Dr. Elizabeth Miller, Dr. Dave Macklin, Mr. Andy Curran, Rosie England, Cathryn James, Dan Haworth, Tracy Rogers, Jo Jenkins, Rosie Furner
Target Audience:
Registered healthcare professionals, Paramedics, Nurses, Midwives
Effective Date:
May 2023
Review Date:
October 2025
Expiry Date:
April 2026
Approval Date:
May 2025
Change History:
Includes updates to drug administration protocols and clinical guidelines
Year:
2024
Region / City:
Plymouth Meeting, Pa.
Topic:
Medication Safety
Document Type:
Press Release
Organization / Institution:
Institute for Safe Medication Practices (ISMP)
Author:
Renee Brehio
Target Audience:
Healthcare professionals, safety experts
Effective Period:
2024
Approval Date:
January 12, 2024
Date of Changes:
January 12, 2024
Year:
2007
Trial Registration:
EudraCT 2007-003666-17
Local R&I Number:
CS/2007/2608
Journal:
The New England Journal of Medicine
Publication Date:
Feb 25, 2016
Authors:
Paul S Myles, Julian A Smith, Andrew Forbes, Brendan Silbert, Mohandas Jayarajah, Thomas Painter, D James Cooper, Silvana Marasco, John McNeil, Jean S Bussieres, S Wallace
Research Network:
ANZCA Clinical Trials Network
Study Type:
Clinical trial
Medical Field:
Cardiac surgery / Pharmacology
Interventions:
Aspirin, Tranexamic Acid
Year:
2013
Region:
North West England
Topic:
Healthcare, Emergency Medicine, Haemorrhage Management
Document Type:
Guideline
Organization:
North West Regional Transfusion Committee (NW RTC)
Authors:
Steering group of NW RTC Major Haemorrhage Guidelines Group
Target Audience:
Healthcare professionals involved in transfusion and emergency care
Effective Period:
Ongoing
Approval Date:
December 2013
Revision Date:
June 2013
Year:
2023
Region / City:
Canberra
Topic:
Health, Medical Procedures
Document Type:
Clinical Procedure
Organization / Institution:
Canberra Health Services
Author:
Unknown
Target Audience:
Medical Professionals, Nurses, Allied Health Professionals
Period of Validity:
Ongoing
Approval Date:
Unknown
Date of Changes:
Unknown
Year:
Not stated
Region:
Canberra, Australian Capital Territory
Thematic area:
Obstetric emergencies
Document type:
Clinical guideline
Issuing organisation:
Canberra Health Services
Clinical focus:
Postpartum haemorrhage (primary and secondary)
Definition of condition:
Blood loss ≥500 mL after childbirth
Target population:
Women during and after childbirth
Intended users:
Medical officers, registered midwives, nurses, midwifery students under supervision
Scope of application:
Antenatal, intrapartum and postpartum care
Care settings:
Vaginal birth and caesarean section
Related conditions:
Maternal morbidity and mortality
Includes sections:
Risk factors, prevention, management, resuscitation, postpartum care, evaluation, references
Year:
2025
Region / City:
UK
Topic:
Healthcare, Medication Guidelines
Document Type:
Medical Protocol
Organisation:
National Ambulance Service Medical Directors (NASMeD)
Author:
Dr. Elizabeth Miller, Dr. Dave Macklin, Mr. Andy Curran, Rosie England, Cathryn James, Dan Haworth, Tracy Rogers, Jo Jenkins, Rosie Furner
Target Audience:
Registered healthcare professionals, Paramedics, Nurses, Midwives
Effective Date:
May 2023
Review Date:
October 2025
Expiry Date:
April 2026
Approval Date:
May 2025
Change History:
Includes updates to drug administration protocols and clinical guidelines
Year:
2020
Region / city:
United Kingdom
Subject:
Haematology, Transfusion Medicine
Document type:
Guideline
Organization:
British Society for Haematology
Author:
Simon J Stanworth, Kerry Dowling, Nikki Curry, Heidi Doughty, Beverley J Hunt, Laura Fraser, Shruthi Narayan, Juliet Smith, Ian Sullivan, Laura Green
Target audience:
Haematology and transfusion professionals, medical practitioners in the UK
Effective period:
From 2020 onwards
Approval date:
Not specified
Amendment date:
Not specified
Descriptor:
Urgent and out-of-hours CT brain undertaken to identify subarachnoid haemorrhage (SAH) or contraindications to subsequent lumbar puncture (LP)
Background:
National guidance requires LP following a normal CT brain in suspected SAH cases
Standard:
LP performed no sooner than 12 hours from symptom onset when CT does not reveal SAH or contraindication
Target:
100%
Indicators:
Percentage of eligible patients undergoing LP ≥12 hours after headache onset
Data Items:
Clinical details in request; time of CT; CT findings; contraindications; timing and result of LP; report timing
Suggested Number:
40 consecutive requests
Resources:
Review of request forms, patient notes, laboratory log books; radiologist time (8 hours)
References:
SIGN Guidelines 107 (2008); NICE CG68 (2008); RCP Stroke Guideline (2012); BMJ, Stroke, Neurologia and other cited journals
Submitted By:
Taken from Clinical Audit in Radiology 100+ recipes RCR 1996, updated by B Morrissey & L Narayanan
Published Date:
Monday 7 January 2008
Last Reviewed:
Thursday 9 January 2020
Reference:
25-J-054
Country:
Wales, United Kingdom
Region / City:
Morriston, South Wales
Institution:
Morriston Hospital
Network:
South Wales Trauma Network
Document Type:
Freedom of Information response
Legislation:
Freedom of Information Act 2000
Legal Framework:
General Data Protection Regulation (GDPR); Data Protection Act 2018
Subject:
Major haemorrhage protocols and clinical guidelines
Clinical Areas:
Trauma; Obstetrics; Surgery; Multispecialty hospital care
Attachments:
Four appendices containing protocol and guideline documents
Appendix 1 Scope:
Trauma cases within the South Wales Trauma Network
Appendix 2 Scope:
Obstetrics
Appendix 3 Scope:
Cross-specialty guidance on major bleeding management
Appendix 4 Scope:
Surgical settings
Information Limitations:
Staff names redacted under Section 40(2) of the Freedom of Information Act 2000
Audit Data:
Not available
Supporting Materials:
Clinical guidelines and standard operating procedures related to transfusion thresholds, blood products, coagulation factor concentrates, and escalation pathways
Year:
2026
Region / city:
International multicenter
Topic:
Cardiology, Hematology
Document type:
Supplementary tables and figures
Institution:
GARFIELD-AF and ORBIT-AF study groups
Authors:
Multi-center registry investigators
Target audience:
Clinicians, researchers
Study period:
2 years follow-up
Data collection:
Patient registries
Patient population:
Adults with atrial fibrillation receiving oral anticoagulants
Measured outcomes:
Incidence of intracranial hemorrhage, baseline characteristics, treatment type, comorbidities, vital signs
Data analysis:
Risk factor association with intracranial hemorrhage
Treatment types:
NOAC, VKA, concomitant antiplatelet therapy