№ lp_1_2_45533
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Guideline for the management of major haemorrhage with a focus on transfusion medicine based on systematic reviews and randomized controlled trials.
Year:
2020
Region / city:
United Kingdom
Subject:
Haematology, Transfusion Medicine
Document type:
Guideline
Organization:
British Society for Haematology
Author:
Simon J Stanworth, Kerry Dowling, Nikki Curry, Heidi Doughty, Beverley J Hunt, Laura Fraser, Shruthi Narayan, Juliet Smith, Ian Sullivan, Laura Green
Target audience:
Haematology and transfusion professionals, medical practitioners in the UK
Effective period:
From 2020 onwards
Approval date:
Not specified
Amendment date:
Not specified
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Note:
Year
Topic:
Haematological malignancies, diagnostic service
Document type:
User Guide
Organization:
Newcastle upon Tyne Hospitals NHS Foundation Trust
Target audience:
Medical professionals, laboratory staff
Description:
This document provides an overview of the services and procedures provided by the Northern England Haemato-Oncology Diagnostic Service (NEHODS), including contact information, sample requirements, and reporting systems.
Year:
2021
Region / City:
Irrua, Nigeria
Subject:
Haematology, Infectious Diseases, Public Health
Document Type:
Research Article
Organization / Institution:
International Blood Research & Reviews
Author:
Abdul-Azeez Bature Ado-Khadeer
Target Audience:
Researchers, Physicians, Legislators
Period of Application:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Context:
A research article analyzing the haematological impacts of Lassa fever and its mortality markers based on a case-control study conducted in Nigeria.
Year:
2023
Region / City:
Ekpoma, Edo State, Nigeria
Topic:
Occupational Health
Document Type:
Research Study
Organization / Institution:
Ambrose Alli University
Author:
Unspecified
Target Audience:
Health Researchers, Occupational Health Professionals
Period of Study:
2023
Approval Date:
Unspecified
Date of Changes:
Unspecified
Year:
2024
Location:
Port Harcourt, Nigeria
Topic:
Hypertension and Haematological Parameters
Document Type:
Research Article
Institution:
University-affiliated Medical Research Center
Authors:
David et al., Ibrahim and Abdalla, Osman et al., Ali et al., Chukwu et al.
Target Population:
Adults aged 30–89 with and without hypertension
Study Design:
Case-control study
Sample Size:
260 participants (160 hypertensives, 100 normotensive controls)
Methods:
Blood analysis including full blood count, ESR, CRP, fibrinogen, albumin
Key Variables:
Age, sex, BMI, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, RBC count
Outcome Measures:
Differences in haematological parameters across hypertensive grades
Tipo di documento:
Modulo di riferimento clinico
Ambito medico:
Oncologia ematologica
Sistema sanitario:
NHS
Organizzazione:
NHS
Destinatari:
Medici di medicina generale e clinici referenti
Scopo:
Invio rapido di pazienti con sospetto tumore ematologico
Patologie considerate:
Leukaemia; Myeloma; Hodgkin’s and Non-Hodgkin’s Lymphoma
Elementi richiesti:
Dati del paziente; Dati dello studio medico; Informazioni cliniche; Risultati di indagini diagnostiche
Esami diagnostici richiesti:
FBC; ESR; serum calcium; renal function; serum protein electrophoresis; serum free light chains; urine Bence Jones protein; LDH; immunoglobulins
Procedure correlate:
Fast track cancer referral pathway
Valutazioni cliniche incluse:
Rockwood Clinical Frailty Scale (CFS)
Informazioni accessibilità:
esigenze di interprete; mobilità; deficit sensoriali; trasporto ospedaliero; controindicazione MRI
Materiali informativi correlati:
Fast track cancer pathway information leaflet
Fonte informativa indicata:
Cancer Matters Wessex
Lingua del documento:
English
Year:
2013
Region:
North West England
Topic:
Healthcare, Emergency Medicine, Haemorrhage Management
Document Type:
Guideline
Organization:
North West Regional Transfusion Committee (NW RTC)
Authors:
Steering group of NW RTC Major Haemorrhage Guidelines Group
Target Audience:
Healthcare professionals involved in transfusion and emergency care
Effective Period:
Ongoing
Approval Date:
December 2013
Revision Date:
June 2013
Year:
2023
Region / City:
Canberra
Topic:
Health, Medical Procedures
Document Type:
Clinical Procedure
Organization / Institution:
Canberra Health Services
Author:
Unknown
Target Audience:
Medical Professionals, Nurses, Allied Health Professionals
Period of Validity:
Ongoing
Approval Date:
Unknown
Date of Changes:
Unknown
Year:
Not stated
Region:
Canberra, Australian Capital Territory
Thematic area:
Obstetric emergencies
Document type:
Clinical guideline
Issuing organisation:
Canberra Health Services
Clinical focus:
Postpartum haemorrhage (primary and secondary)
Definition of condition:
Blood loss ≥500 mL after childbirth
Target population:
Women during and after childbirth
Intended users:
Medical officers, registered midwives, nurses, midwifery students under supervision
Scope of application:
Antenatal, intrapartum and postpartum care
Care settings:
Vaginal birth and caesarean section
Related conditions:
Maternal morbidity and mortality
Includes sections:
Risk factors, prevention, management, resuscitation, postpartum care, evaluation, references
Year:
2025
Region / City:
UK
Topic:
Healthcare, Medication Guidelines
Document Type:
Medical Protocol
Organisation:
National Ambulance Service Medical Directors (NASMeD)
Author:
Dr. Elizabeth Miller, Dr. Dave Macklin, Mr. Andy Curran, Rosie England, Cathryn James, Dan Haworth, Tracy Rogers, Jo Jenkins, Rosie Furner
Target Audience:
Registered healthcare professionals, Paramedics, Nurses, Midwives
Effective Date:
May 2023
Review Date:
October 2025
Expiry Date:
April 2026
Approval Date:
May 2025
Change History:
Includes updates to drug administration protocols and clinical guidelines
Year:
2016
Region / city:
Global
Topic:
Maternal health, Post-partum haemorrhage
Document type:
Research review
Organization / institution:
British Journal of Haematology, St Bartholomew’s Hospital, London School of Hygiene and Tropical Medicine
Author:
Stephen P Hibbs, Ian Roberts, Haleema Shakur-Still, Beverley J Hunt
Target audience:
Healthcare professionals, researchers, policymakers
Period of validity:
Ongoing
Approval date:
Not specified
Date of revisions:
Not specified
Descriptor:
Urgent and out-of-hours CT brain undertaken to identify subarachnoid haemorrhage (SAH) or contraindications to subsequent lumbar puncture (LP)
Background:
National guidance requires LP following a normal CT brain in suspected SAH cases
Standard:
LP performed no sooner than 12 hours from symptom onset when CT does not reveal SAH or contraindication
Target:
100%
Indicators:
Percentage of eligible patients undergoing LP ≥12 hours after headache onset
Data Items:
Clinical details in request; time of CT; CT findings; contraindications; timing and result of LP; report timing
Suggested Number:
40 consecutive requests
Resources:
Review of request forms, patient notes, laboratory log books; radiologist time (8 hours)
References:
SIGN Guidelines 107 (2008); NICE CG68 (2008); RCP Stroke Guideline (2012); BMJ, Stroke, Neurologia and other cited journals
Submitted By:
Taken from Clinical Audit in Radiology 100+ recipes RCR 1996, updated by B Morrissey & L Narayanan
Published Date:
Monday 7 January 2008
Last Reviewed:
Thursday 9 January 2020
Reference:
25-J-054
Country:
Wales, United Kingdom
Region / City:
Morriston, South Wales
Institution:
Morriston Hospital
Network:
South Wales Trauma Network
Document Type:
Freedom of Information response
Legislation:
Freedom of Information Act 2000
Legal Framework:
General Data Protection Regulation (GDPR); Data Protection Act 2018
Subject:
Major haemorrhage protocols and clinical guidelines
Clinical Areas:
Trauma; Obstetrics; Surgery; Multispecialty hospital care
Attachments:
Four appendices containing protocol and guideline documents
Appendix 1 Scope:
Trauma cases within the South Wales Trauma Network
Appendix 2 Scope:
Obstetrics
Appendix 3 Scope:
Cross-specialty guidance on major bleeding management
Appendix 4 Scope:
Surgical settings
Information Limitations:
Staff names redacted under Section 40(2) of the Freedom of Information Act 2000
Audit Data:
Not available
Supporting Materials:
Clinical guidelines and standard operating procedures related to transfusion thresholds, blood products, coagulation factor concentrates, and escalation pathways
Year:
2026
Region / city:
International multicenter
Topic:
Cardiology, Hematology
Document type:
Supplementary tables and figures
Institution:
GARFIELD-AF and ORBIT-AF study groups
Authors:
Multi-center registry investigators
Target audience:
Clinicians, researchers
Study period:
2 years follow-up
Data collection:
Patient registries
Patient population:
Adults with atrial fibrillation receiving oral anticoagulants
Measured outcomes:
Incidence of intracranial hemorrhage, baseline characteristics, treatment type, comorbidities, vital signs
Data analysis:
Risk factor association with intracranial hemorrhage
Treatment types:
NOAC, VKA, concomitant antiplatelet therapy
Year:
2023
Region / City:
Colchester
Topic:
Haematology, Blood Transfusion, Phlebotomy
Document Type:
User Guide
Organization / Institution:
East Suffolk and North Essex NHS Foundation Trust
Author:
Kathryn Hurst
Target Audience:
Hospital and community users of laboratory services
Effective Period:
From 1st July 2019
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2022
Region / city:
Birmingham
Subject:
Paediatric Oncology and Haematology
Document type:
Capability Framework
Organization / institution:
Royal College of Nursing, Children’s Cancer and Leukaemia Group (CCLG)
Author:
Sally Spencer, Helen Woodman
Target audience:
Advanced Clinical Practitioners, Clinical Supervisors
Period of validity:
Until March 2023
Date of approval:
March 2022
Date of revisions:
Annually for first three years, then every three years
Year:
(not specified)
Region / city:
(not specified)
Topic:
Haematology, von Willebrand disease
Document type:
Audit report
Organization / institution:
British Society for Haematology
Author:
(not specified)
Target audience:
Healthcare professionals in haematology
Period of validity:
(not specified)
Approval date:
(not specified)
Date of changes:
(not specified)
Year:
2023
Region / City:
East of England
Topic:
Transfusion management, Haematology
Document type:
Toolkit
Institution:
East of England Regional Transfusion Committee
Author:
Nicola Jones
Target audience:
Haematology Consultants, Transfusion Leads, Hospital Transfusion Committees
Action period:
Not specified
Approval date:
Not specified
Date of amendments:
Not specified
Date:
17 July 2024
Time:
10.30–11.30
Document Type:
Draft Minutes
Group:
London & South East Haematology & Trauma Group
Chair:
Fatts Chowdhury
Organisations Represented:
NHSBT; St Mary’s Hospital; Coventry & Warwickshire Path Services; Imperial College Healthcare NHS Trust; King’s College Hospital; University Hospitals Sussex; St George’s Hospital; University Hospital Coventry; University Hospital Southampton; Lincoln County Hospital; Barts Health NHS Trust; University Hospitals Plymouth; James Cook University Hospital; John Radcliffe Hospital Oxford; Addenbrookes Cambridge; St James University Hospital
Agenda Items:
Welcome and Introductions; Previous Minutes; Updates – Major Trauma Centres and KSS; Review Stock Position
Key Topics:
Blood stock levels; O-negative shortage; Plasma group changes; Platelet usage policy; RBC, FFP, PLT and Cryo issuance and wastage; LIMS switchover; Synnovis cyber attack; Patient Blood Management; Media campaign for donor recruitment
Related Period:
Previous meeting held on 24 April 2024
Author:
Stephen Leather
Owner:
Richard Adams
Approved by:
Richard Adams, Stephen Leather, Mark Longman
Review Interval:
2 years or as required
Location of Hardcopies:
Cross site document-Electronic copy only(access via laboratory handbook website and Q pulse)
Changes from last version of this document:
Changed title of document to Haematology Reference Ranges, as it now also contains ESR reference ranges. Added normal range for immature granulocytes.
Background:
A reference range or reference interval is the range of values that is deemed normal for a physiological measurement in healthy persons. The standard definition of a reference range for a particular measurement is defined as the interval between which 95% of values of a reference population fall into, in such a way that 2.5% of the time a value will be less than the lower limit of this interval, and 2.5% of the time it will be larger than the upper limit of this interval, whatever the distribution of these values.
Normal ranges in adults:
Reference ranges have been verified based on the local population. A sample of over 500 normal results was gathered and a mean and standard deviation for each parameter was obtained. Any outliers (>3.0 SD) were removed, and an upper and lower limit were obtained by calculation of the 2.5 and 97.5 percentile. This data is stored on Q pulse HA-INF-REFHAEM DATA. For the reticulocyte normal range, results from over 3500 patients were gathered and a range established as detailed above. This data is stored on Q pulse HA-INF-REFRETIC DATA. Our reference ranges were compared against published literature providing ranges established by national and/or international consensus. In order to provide a harmonised normal range between York and Scarborough a lymphocyte range of 0.5-4.0 was selected. All requests sent to the lab with no age or sex, may be entered as unknown, and therefore will be allocated an adult female reference range. All reference ranges are to 1 decimal place. The pregnancy Haemoglobin (Hb) reference range was taken from the BCSH guidance and agreed by the Consultant for Obstetrician and Gynaecologist for all women marked as pregnant.
Normal ranges in infants and children:
Due to issues surrounding generation of internal ranges due to lack of available data; reference ranges for children are wholly derived from several published sources.
ESR reference ranges:
In healthy subjects, the erythrocyte sedimentation rate (ESR) is higher in women than in men, and in both sexes, a rise occurs with age.
References:
Practical Haematology, 11th edition 2012, Dacie & Lewis. Blood Cells-A Practical Guide, 4th edition, 2006, Barbara J Bain. Pediatric Haematology, 3rd edition 2006 Robert J. Arceci et al