№ files_lp_3_process_9_51404
Experimental research article describing the effects of anesthesia alone versus anesthesia combined with minor surgery on cell death and gene expression in the developing piglet brain.
Year: 2026
Region / City: London, UK and Paris, France
Topic: Neuroscience / Pediatric Anesthesia
Document type: Research article
Institutions: University College London, Kings College London, Inserm U1141, University Paris Diderot, University of Wisconsin-Madison
Authors: Kevin D. Broad, Go Kawano, Igor Fierens, Eridan Rocha-Ferreira, Mariya Hristova, Mojgan Ezzati, Jamshid Rostrami, Daniel Alonso-Alconada, Badr Chaban, Jane Hassell, Bobbi Fleiss, Pierre Gressens, Robert D. Sanders, Nicola J. Robertson
Target audience: Neuroscientists, anesthesiologists, pediatric researchers
Study period: Experimental procedures conducted on neonatal piglets
Approval and ethics: UK Home Office and UCL Ethics Board approval under Animal (Scientific Procedures) Act 1986 and EEC directive 86/609/EEC
Methods: Comparative analysis of anesthesia alone versus anesthesia plus minor surgery; cell death quantified by TUNEL assay; gene expression analyzed via RNAseq
Key terms: Isoflurane, anesthetic toxicity, apoptosis, inflammation, endothelial function, neural plasticity, GABA-A, surgery
Price: 8 / 10 USD
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