№ files_lp_4_process_3_101218
Year: 2026
Region / City: Hamilton, Ontario, Canada
Topic: Alzheimer’s disease and neurodegeneration
Document type: Scientific article
Institution: McMaster University, Department of Psychiatry and Behavioural Neurosciences
Author: Margaret Fahnestock, PhD
Target audience: Researchers and clinicians in neuroscience and psychiatry
Keywords: BDNF, amyloid-beta, Alzheimer’s disease, cognitive impairment, CREB, neurotrophin
Abbreviations: Aβ, AD, APP, BDNF, CREB, ELISA, FAD, MCI
Research methods: Literature review, analysis of human and transgenic mouse data
Key findings: BDNF down-regulation by soluble amyloid-beta, role of CREB in BDNF expression, mechanisms of synaptic loss and tau pathology
End of study focus: Molecular pathways linking amyloid-beta to cognitive decline in Alzheimer’s disease
Summary type: Academic review
Price: 8 / 10 USD
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