№ files_lp_3_process_7_019710
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Peer-reviewed minireview article summarizing current knowledge on the biology, regulation, pathological transformation, and therapeutic prospects of intestinal stem cells in mammalian epithelium.
Journal:
World Journal of Gastroenterology
Manuscript Number:
25986
Manuscript Type:
Minireview
Title Running:
Current understanding concerning ISCs
Authors:
Shuang Cui; Peng-Yu Chang
Affiliation:
Department of Radiation Oncology, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province, China
Corresponding Author:
Peng-Yu Chang, MD
Funding:
National Natural Science Foundation of China (No. 81502751; No. 81372929)
Conflict of Interest:
None declared
Open Access License:
Creative Commons Attribution Non Commercial (CC BY-NC 4.0)
Manuscript Source:
Invited manuscript
Received Date:
March 27, 2016
Accepted Date:
June 15, 2016
Keywords:
Intestinal stem cell; Cell development; Colorectal cancer
Publisher:
Baishideng Publishing Group Inc.
Year:
2016
Price: 8 / 10 USD
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Year:
2024
Region / city:
Australia
Document Type:
Medical Submission
Organization / Institution:
PBAC
Author:
Not specified
Target audience:
Medical practitioners, pharmaceutical authorities
Period of validity:
Not specified
Approval date:
Not specified
Amendment date:
November 2024
Note:
Context
Year:
2023
Region / city:
Australia
Document type:
Submission for drug listing
Institution:
TGA (Therapeutic Goods Administration)
Author:
STADA Pharmaceuticals Australia Pty Ltd
Target audience:
Medical practitioners, healthcare professionals, policymakers
Period of validity:
Not specified
Approval date:
August 29, 2023
Date of amendments:
Not specified
Clinical claim:
LECIG is non-inferior in terms of efficacy and safety compared to LCIG
Registration status:
TGA registered
Field:
Gastroenterology
Topic:
Metabolic endoscopy and type 2 diabetes treatment
Type of document:
Clinical study report
Study design:
First in-human extension study
Intervention:
Proximal Intestinal Mucosal Ablation (PIMA)
Preceding study registration:
NCT05887635
Medical condition:
Type 2 diabetes (T2D)
Primary outcomes:
Safety, tolerability, feasibility, efficacy
Sample size:
8 patients
Patient characteristics:
Uncontrolled T2D (HbA1c 7.5–10.0%) despite ≥1 glucose lowering agent
Procedure details:
Up to 75 cm post-ampullary mucosal ablation using second-generation through-the-scope RFVA catheter
Anaesthesia:
General anaesthesia
Follow-up period:
3 months
Key measurements:
HbA1c, HOMA-IR, BMI, adverse events, VAS pain score
Authors:
Noelia Rodriguez Mier; Senne Cuyx; Kris De Boeck; Marijke Proesmans; Mieke Boon; Lieven Dupont; Kaline Arnauts; Elke De Wachter; Stephanie Van Biervliet; Monique Lequesne; Vicky Nowé; Hedwige Boboli; Anabela Santo Ramalho; François Vermeulen; on behalf of the Belgian Organoid Project
Affiliations:
KU Leuven; University Hospital Leuven; University Hospital Brussels; Ghent University Hospital; Antwerp University Hospital; GZA Hospital; CHR Citadelle
Country:
Belgium
Research field:
Cystic fibrosis; CFTR modulators; organoid research; personalized medicine
Study population:
60 people with cystic fibrosis homozygous for F508del
Genetic focus:
F508del CFTR mutation (homozygous)
Interventions studied:
Elexacaftor/tezacaftor/ivacaftor; Tezacaftor/ivacaftor
Methods:
Patient-derived intestinal organoids from rectal biopsies; forskolin-induced swelling assay; comparison with clinical outcomes
Clinical outcomes assessed:
Lung function; sweat chloride levels; body weight; pulmonary exacerbations
Type of document:
Scientific research article
Source:
PubMed
DOI / Identifier:
40883119
Subject:
Intestinal surgery and anastomosis techniques
Type of document:
Educational surgical reference text
Field:
Veterinary surgery
Species:
Cats and dogs
Surgical focus:
Small intestinal resection and anastomosis
Suture materials discussed:
Silk, Dacron, Nylon, Polypropylene, Chromic gut, Polyglycolic acid (Dexon), Polygalactin 910 (Vicryl), Polydioxanone (PDS), Polyglyconate (Maxon), Poliglecaprone (Monocryl), Biosyn
Stapling devices mentioned:
Auto Suture 35 skin stapler, GIA stapler, TA stapler
Key surgical considerations:
Suture selection, suture pattern, needle type, omental flap coverage, serosal patching
Complications addressed:
Leakage, peritonitis, short bowel syndrome, mucosal eversion
Anatomical focus:
Small intestine, mesenteric border, antimesenteric border, greater omentum
Authors:
Yan Xu; Yong-Li Dai; Hong Lei; Ying-Lun Yuan; Tian-Le Hu; Xia Wei; Lin-Mei Guo; Yong-Mei Lan
Corresponding Authors:
Lin-Mei Guo; Yong-Mei Lan
Study Period:
November 2024–March 2025
Location:
Lanzhou, Gansu, China
Type of Document:
Original research article
Field:
Paediatric medicine; Microbiology; Clinical immunology
Study Population:
Children aged 3–14 years
Sample Size:
90 participants (30 MPP; 30 NMP; 30 healthy controls)
Methods:
16S rRNA sequencing; serum trace element detection; clinical laboratory analysis
Ethics Approval:
Approved by hospital ethics committee (2024KY22213)
Keywords:
16S rRNA; children; iron; intestinal flora; Mycoplasma pneumoniae pneumonia; zinc
Document type:
Supplementary material
Components:
Supplementary Figures; Supplementary Table; Supplementary references
Figures included:
Figure S1; Figure S2; Figure S3; Figure S4
Table included:
Table S1
Research topic:
Gut microbiota, intestinal inflammation and ulcerative colitis in murine models
Experimental subjects:
Mice
Biological focus:
Colonic tissue; intestinal barrier function; immune response; gut microbiota at genus level
Analytical methods mentioned:
Western blot; immunoblot; densitometric analysis
Key elements:
SCR-CDs synthesis; organ weight measurement; bacterial genera classification as beneficial or harmful; associated pathological states
Referenced conditions:
Ulcerative colitis; inflammatory bowel disease; colitis
Cited works:
Peer-reviewed journal articles with DOIs listed
Year:
Not specified
Region / City:
Basel, Switzerland
Field:
Parasitology
Document Type:
Supplementary scientific protocol and validation data
Institution:
Swiss Tropical and Public Health Institute (SwissTPH)
Department:
National Reference Centre for Parasitology
Methodology:
Real-time PCR using TaqMan probe assays
Assay Format:
Six duplex real-time PCR reactions and one simplex reaction
Target Organisms:
Entamoeba dispar, Entamoeba histolytica, Cryptosporidium spp., Cryptosporidium hominis/parvum, Microsporidia (Encephalitozoon spp., Enterocytozoon bieneusi), Entamoeba moshkovskii, Entamoeba polecki, Dientamoeba fragilis, Giardia lamblia, Cyclospora cayetanensis, Cystoisospora belli, Blastocystis sp.
Gene Target:
18S rRNA gene
Sample Type:
Human stool samples
Validation Material:
Plasmids with sequence inserts and clinical samples
Analytical Sensitivity:
1–10 plasmids/µl depending on assay
Diagnostic Sensitivity:
Reported up to 100% for validated assays
Specificity:
100% for tested organisms during validation
Laboratory Method:
Quantitative real-time polymerase chain reaction (qPCR)
Thermocycling Profile:
50 °C for 2 min, 95 °C for 10 min, followed by 40 cycles of 95 °C for 15 s and 58 °C for 1 min
DNA Extraction Material:
Approximately 1 g stool aliquots stored at −80 °C prior to molecular analysis
Reagents:
GeneExpression Mastermix (Thermo Fisher Scientific), primers and TaqMan probes
Year:
2023
Region / City:
Padova, Italy
Topic:
Pharmaceutical Development, Drug Solubility
Document Type:
Research Study
Organization / Institution:
University of Padova, GlaxoSmithKline
Author:
Marco Brendolan, Francesca Cenci, Konstantinos Stamatopoulos, Fabrizio Bezzo, Pierantonio Facco
Target Audience:
Pharmaceutical Researchers, Bioengineers
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2021
Region / City:
New York, NY, USA
Subject:
Endocrinology, Metabolism
Document Type:
Research Article
Organization / Institution:
Columbia University, University of Cambridge, Case Western Reserve University
Authors:
Rossana M. Calderon, Christopher A. Smith, Emily L. Miedzybrodzka, Josie A. Silvaroli, Marcin Golczak, Fiona M. Gribble, Frank Reimann, William S. Blaner
Target Audience:
Researchers, medical professionals, endocrinologists
Period of Action:
Ongoing
Approval Date:
2021-01-01
Date of Changes:
N/A
Keywords:
Retinol-binding protein 2, Retinoids, Enteroendocrine cells, GIP, GLP-1, Obesity, Glucose intolerance, Metabolic diseases
Abstract:
Retinol-binding protein 2 (RBP2) is essential for enteroendocrine cell function in the intestine, influencing the secretion of incretins such as GIP and GLP-1, and plays a critical role in metabolic processes like glucose homeostasis and obesity.
Year:
2026
Region / City:
Adelaide, SA
Subject:
Microbiome, Health, Biosecurity, Research Career Development
Document Type:
Job Description
Organization / Institution:
CSIRO
Author:
CSIRO Human Resources
Target Audience:
Australian/New Zealand Citizens, Australian Permanent Residents, Australian Temporary Residents
Effective Period:
3 years full-time
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2022
Region / City:
Kolkata, India
Topic:
Intestinal parasitic co-infection, Segmental colitis
Document Type:
Case Report
Institution:
Institute of Post Graduate Medical Education & Research, SSKM Hospital, Kolkata
Authors:
Dr. Sanchari Bairagya, Dr. Dipankar Paul, Dr. Kumkum Bhattacharyya
Target Audience:
Medical professionals, researchers, students in microbiology and gastroenterology
Date of Approval:
2022
Date of Modification:
Not specified
Keywords:
Protozoa, Helminths, Co-infection, Segmental colitis, Giardia intestinalis, Hymenolepis nana, Strongyloides stercoralis
Year:
2026
Region / City:
Grand Forks, North Dakota, USA
Subject:
Clinical Case Report, Small Bowel Volvulus
Document Type:
Case Report
Institution:
University of North Dakota, School of Medicine & Health Sciences
Authors:
Henry Elsenpeter, Paxten Wahlund, Selly Strauch, Susan Roe
Corresponding Author:
Henry Elsenpeter
Target Audience:
Medical professionals, forensic pathologists
Period of Study:
2026
Investigation Type:
Medico-legal death investigation
Patient Age:
85 years
Patient Sex:
Female
Medical History:
Hypothyroidism
Cause of Death:
Small bowel volvulus with necrotic ileum
Key Findings:
Ileum necrosis, peritoneal hemorrhage, cecal and splenic adhesions
Year:
2016
Region / City:
Fort Eustis, Virginia
Topic:
Military Awards and Decorations
Document Type:
Regulation
Organization:
U.S. Army Training and Doctrine Command (TRADOC)
Author:
Deputy Chief of Staff, G-3/5/7, G-34 (Protection Directorate)
Target Audience:
TRADOC Military Police Law and Order Detachments
Period of Validity:
Annual
Approval Date:
16 September 2016
Change Date:
16 September 2016
Note:
Year
Name:
Yiqin Du
Position Title:
Professor
Current Institution:
University of South Florida
Field of Expertise:
Ophthalmology; Stem Cell Biology
Education:
MD in Clinical Medicine; PhD in Ophthalmology
Research Areas:
Corneal regeneration; Trabecular meshwork regeneration; Glaucoma; Stem cell therapies
Clinical Background:
Ophthalmology; Cornea and glaucoma surgery
Employment History:
Xuzhou Third Hospital; University of Pittsburgh; University of South Florida
Grant Support:
NIH/NEI R01 grants
Funding Agencies:
National Institutes of Health; National Eye Institute
Research Period Covered:
1987–2029
Publications:
Peer-reviewed journal articles in ophthalmology and stem cell research
Authorship Role:
Principal Investigator; Co-Principal Investigator
Year:
2026
Region / City:
South Carolina
Topic:
STEM Education
Document Type:
Concurrent Resolution
Authority/Organization:
South Carolina General Assembly
Target Audience:
Residents of South Carolina, Educators, Industry Professionals
Effective Period:
March 25, 2026
Approval Date:
January 29, 2026
Amendment Date:
N/A
Contextual Description:
Legislative resolution recognizing the importance of STEM education in South Carolina and establishing March 25, 2026, as STEM Education Day.
Year:
2025
Region / City:
Ohio
Topic:
STEM, Scholarships
Document Type:
Scholarship Application
Organization / Institution:
The Goodyear Tire & Rubber Company
Author:
The Goodyear Tire & Rubber Company
Target Audience:
High school seniors in Ohio
Period of Validity:
Until January 12, 2025
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2024
Region / City:
Parramatta
Topic:
Artificial Intelligence in Education
Document Type:
Report
Institution:
Our Lady of Mercy College Parramatta
Author:
Tony Tang
Target Audience:
Teachers, Educational Leaders, School Communities
Period of Validity:
Ongoing
Approval Date:
2024
Date of Last Revision:
2024