№ files_lp_4_process_3_088910
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Report on clinical trial results showing participant response rates, fecal microbiome changes, and safety outcomes for an orally administered investigational therapy targeting recurrent Clostridioides difficile infections.
Year: 2026
Region / City: Rochester, MN, USA
Topic: Microbiome modulation in Clostridioides difficile infection
Document Type: Clinical trial report
Institution: Mayo Clinic; Rebiotix Inc; BioRankings LLC
Authors: Sahil Khanna, MBBS; Darrell S. Pardi, MD; Courtney Jones; William D. Shannon, PhD, MBA; Carlos Gonzalez, MS; Ken Blount, PhD
Target Audience: Medical researchers, gastroenterologists, microbiologists
Study Phase: Phase 1
Treatment: RBX7455 orally administered live biotherapeutic
Sample Type: Fecal samples from study participants
Outcome Measures: Safety, efficacy, microbiome composition shifts
Time Points: Baseline, Day 1, Week 1, Week 4, Week 8, Week 12, Week 24
Analysis Methods: Dirichlet multinomial fitting, repeated measures analysis (DMRepeat)
Publication References: La Rosa PS et al., PLoS One 2012; Shannon WD, BioRankings Technical Report #3
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