№ files_lp_4_process_3_074535
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High throughput genetic screening data and sequence information for identifying T cell receptor therapeutic targets in multiple human and model antigens.
Year:
2023
Institution:
Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, Rockefeller University
Program:
Molecular Pharmacology Program; Tri-Institutional MD-PhD Program
Authors:
Ron S. Gejman, Heather F. Jones, Martin G. Klatt, Aaron Y. Chang, Claire Y. Oh, Smita S. Chandran, Tatiana Korontsvit, Viktoriya Zakahleva, Tao Dao, Christopher A. Klebanoff, David A. Scheinberg
Document Type:
Supplementary data
Species:
Human, Mouse, Chicken, S. cerevisiae
Experimental Techniques:
Minigene sequencing, TCR mimic antibody binding, co-culture assays
Data Availability:
DOIs provided for sequencing datasets
Target Proteins:
WT1, PRAME, CMV pp65, MART-1, NY-ESO-1, HTLV-1 Tax, ELAV-like protein 4, ADCY4, EFNA1, SH3TC1, HARBI1, PEDF
Sequences Included:
DNA and protein sequences for TCR and antigen constructs
Endogenous or Model Systems:
T2 cells, RMA/S cells, splenocytes
Supplemental Tables:
S1–S3
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2022
Region / City:
Sophia Antipolis, France
Topic:
5G NR User Equipment Application Layer Data Throughput Performance
Document Type:
Technical Report
Organization / Institution:
3rd Generation Partnership Project (3GPP)
Author:
3GPP Organizational Partners
Target Audience:
Engineers, Technicians, Researchers in Telecommunications
Period of Effectiveness:
N/A
Approval Date:
N/A
Modification Date:
N/A
Year:
2022
Region / City:
Global
Topic:
Wireless LAN, IEEE Standards
Document Type:
Amendment
Organization / Institution:
IEEE
Author:
IEEE Working Group
Target Audience:
Manufacturers, network administrators, engineers
Effective Period:
N/A
Approval Date:
N/A
Revision Date:
N/A
Year:
2024
Region / City:
Scottsdale, AZ; Tucson, AZ
Topic:
Salmonella Testing, Microarray Technology, Pathogen Detection
Document Type:
Research Paper
Organization / Institution:
PathogenDx
Authors:
Dr. Mike Hogan, Dr. Susan Evans, Dr. Benjamin A Katchman
Target Audience:
Researchers, Food Safety Professionals, Regulatory Bodies
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2024
Region / City:
International
Subject:
Nuclear medicine, breast cancer, estrogen receptor imaging
Document type:
Procedure standard / Practice guideline
Organization:
SNMMI, EANM
Authors:
David Mankoff, Sona Balogova, Lisa Dunnwald, Farrokh Dehdashti, Erik DeVries, Laura Evangelista, Michel Van Krutchen, Sofia Carriho Vaz, Amy Fowler, Hannah Linden, Gary Ulaner
Target audience:
Nuclear medicine practitioners, oncologists
Scope period:
Current clinical practice
Approval date:
2024
Revision cycle:
Every 5 years or sooner if indicated
Description:
Clinical guideline detailing standardized procedures for [18F]FES PET imaging of estrogen receptor expression in breast cancer patients, including methodology, interpretation, and quality assurance for diagnostic nuclear medicine.
Year:
2013
Region / City:
Leeds, Yorkshire and The Humber
Theme:
Clinical trials, Chronic Kidney Disease
Document type:
Research study protocol
Organization:
University of Birmingham Clinical Trials Unit, Hull and East Yorkshire Hospitals NHS Trust
Author:
Prof Sunil Bhandari
Target audience:
Healthcare professionals, nephrologists, researchers
Period of validity:
3 years
Approval date:
2013
Change date:
N/A
Study reference number:
11/30/07
Ethics committee reference:
13/YH/0394
EudraCT number:
2013-003798-82
Sponsor:
Hull and East Yorkshire Hospitals NHS Trust
Funding source:
Efficacy and Mechanism Evaluation (EME) programme, National Institute for Health Research (NIHR), Medical Research Council (MRC)
Note:
Contextual description
Year:
2023
Region / city:
Sweden, Denmark, Norway
Topic:
Glucagon-like peptide-1 (GLP-1) receptor agonists, liver events, cohort study
Document type:
Research study
Organization / institution:
None specified
Author:
Engström et al.
Target audience:
Medical researchers, healthcare professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of amendments:
Not specified
Authors:
Chenao Li; Yaochi Guo; Xin Guan; Hui Chen; Yong Zhang; Pengyuan Yang; Jizhong Lou
Affiliations:
State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China
Correspondence:
[email protected]
Institutions:
Chinese Academy of Sciences; Institute of Biophysics
Type of document:
Scientific research methods section
Field:
Computational immunology; protein sequence modeling; T cell receptor design
Datasets:
Tpp; Tchard; McPAS-TCR; VDJdb; IEDB; 10x Genomics; ImmuneCODE; TBAdb; MIRA; NetTCR-2.0; TABR; PDB; STCRDab
Sample size:
157k positive samples; 300k negative samples; 519k entries in K1; 5,000 samples in K3; 600k natural CDR3β sequences; 260 bound and 86 unbound TCR structures
Methodology:
Sequence generation model inspired by UniLM and BERT; binding and naturalness classifiers; structure prediction module
Data processing:
Length filtering; de-duplication; train/validation/test splits; ROC-based threshold optimization
Geographical location:
Beijing, China
Year:
2022
Location:
Europe (France, Belgium, Italy, Sweden, Estonia, Israel, Slovakia, Latvia, Czech Republic)
Theme:
Neurodegenerative diseases, Wolfram syndrome, ALS, Parkinson’s disease, ATAD3A disorders, Sigma-1 receptor
Document type:
Conference program
Organizers:
Various academic and clinical institutions in Europe
Sessions:
7 scientific sessions, poster presentations, gala dinner, sightseeing
Presenters:
Nolwen Le Floch, Benjamin Delprat, Elodie Richard, Catherine Verfaillie, Marco Peviani, Angela Cenci Nilsson, Vinay Choubey, Tamar Harel, Shlomit Ezer, Martina Skopkova, Tangui Maurice, Patricia Melnyk, Liga Zvejniece, Geert Bultynck, Michal Cagalinec, Jan Skoda, Barbara Ehrlich, Matej Hotka, Alexandra Zahradnikova Jr
Dates:
October 26–27, Wednesday–Thursday
Target audience:
Researchers, clinicians, and professionals in neurodegenerative disease research
Format:
In-person and online presentations
Year:
2026
Region / city:
Missouri
Document Type:
Proposal
Organization:
MO HealthNet
Author:
MO HealthNet, Conduent
Target Audience:
MO HealthNet participants, healthcare providers
Period of validity:
Ongoing
Approval Date:
January 20, 2026
Revision Date:
May 21, 2008
Criteria Status:
Revision of Existing Criteria
Document type:
Supplementary table
Database:
Web of Science
Search platform:
ISI
Content type:
Search strategy
Research area:
Cardiovascular diseases and GLP-1 receptor agonists
Keywords included:
Cardiovascular diseases, cardiac events, heart failure, hypertension, myocardial ischemia, atherosclerosis, exenatide, liraglutide, dulaglutide, semaglutide, tirzepatide and related compounds
Search structure:
Boolean operators with grouped synonyms
Purpose:
Identification of relevant scientific literature
Year:
2021
Region / City:
Rome, Italy
Field:
Cancer Research
Document Type:
Article
Organization / Institution:
Sapienza University of Rome, University of Milan, Consiglio Nazionale delle Ricerche (CNR), University of Trento, University of Ferrara
Authors:
Guerriero, Claudia; Manfredelli, Marianna; Matera, Carlo; Iuzzolino, Angela; Conti, Luciano; Dallanoce, Clelia; De Amici, Marco; Trisciuoglio, Daniela; Tata, Ada Maria
Target Audience:
Researchers in Cancer Biology
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Keywords:
glioblastoma; cancer stem cells; M2 muscarinic receptor; orthosteric and dualsteric muscarinic agonism; autophagy; apoptosis; mTORC1
Funding:
Ateneo Sapienza Funds
References:
Aoki H, 2008, Autophagy, V4, P467, DOI 10.4161/auto.5668
Context:
Scientific article exploring the role of M2 muscarinic receptor stimulation in inducing autophagy and apoptosis in glioblastoma cancer stem cells, and the differential effects of orthosteric and dualsteric agonists.
Year:
2023
Region / City:
Not specified
Subject:
Medical research, Gastroenterology, Endoscopic Procedures
Document type:
Research Supplement
Organization:
Not specified
Author:
Natalia Tejada, M.D., Ishak Mansi, M.D., Silvio W. de Melo Jr., M.D.
Target audience:
Healthcare professionals, Researchers
Validity period:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2014
Region / city:
Wuhan, Hubei Province, China; Essen, Germany
Topic:
Hepatitis B virus; Interferon; Toll-like receptor
Document type:
Research article
Institution:
Wuhan Institute of Virology, Chinese Academy of Sciences; Institute of Virology, University Hospital of Essen
Author:
Pei RJ, Chen XW, Lu MJ
Target audience:
Researchers in virology, immunology, and hepatitis B treatment
Period of action:
Not specified
Date of approval:
April 15, 2014
Date of revisions:
February 28, 2014
Keywords:
Hepatitis B virus; Interferon; Toll-like receptor; Interferon stimulated genes; Innate immune response
Year:
2020
Region / City:
UTM Zone 11, California, USA
Subject:
Air quality modeling and emissions data
Document type:
Technical input files
Organization / Agency:
MMIF / AERMOD project
Author:
Unspecified / Project team
Target audience:
Environmental engineers, air quality modelers
Source coverage:
Heavy-duty onroad, nonroad, and point sources
Receptor type:
Gridded 1-km receptors, census block receptors, monitors
Temporal resolution:
Hourly emissions, monthly outputs, annual concentrations
Input data:
Meteorological data from MMIF_AERMET_2020
Processing software:
AERMOD, AERMET, MMIF pre-processor
File formats:
.inp, .dat, .txt
Year:
2017–2018
Region / City:
Ilorin, Kwara State, Nigeria
Topic:
Hematology / Iron Status
Document Type:
Original Research Article
Institution:
University of Ilorin Teaching Hospital
Author:
Not specified
Target Population:
Healthy Nigerian adults aged 18–70
Sample Size:
112 participants
Methods:
Cross-sectional study, full blood count, ELISA for serum ferritin and soluble transferrin receptor, TSAT calculation
Inclusion Criteria:
Adults aged 18–70 with consent
Exclusion Criteria:
Hematinics use, blood donors, recent transfusion, febrile illness
Statistical Analysis:
SPSS version 22.0, p-value < 0.05
Reference Ranges Established:
Serum ferritin 20.0–218.4 ng/ml, TSAT 21.5–47.4%, sTfR 8.8–26.9 nmol/L
Year:
2018
Region / City:
Greater London
Topic:
Environmental noise pollution
Document Type:
Research Supplementary Figure
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, Environmental Scientists
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2011
Study Type:
Estrogen Receptor Transcriptional Activation (Human cell Line, HeLa-9903)
Test Material:
[chemical name not specified]
CAS Number:
[#]
Purity:
[#]%
Sponsor:
[Name of Study Sponsor]
Laboratory:
[lab], location not specified
PC Code:
(if applicable)
DP Barcode:
(if applicable)
TXR Number:
(if applicable)
Cytotoxicity Method:
Not specified
Vehicle:
Solvent with final concentration [%]
Reference Substances:
17β-estradiol, 17α-estradiol, Corticosterone, 17α-methyltestosterone
Compliance:
GLP, Quality Assurance and Data Confidentiality statements [provided/not provided]
Exposure Duration:
23 ±1 hours
Cell Line:
hERα-HeLa-9903
Plate Type:
96-well plate
Incubation Conditions:
37°C, 5% CO₂
Replication:
Triplicate wells per concentration
Assay System:
Steady-Glo® Luciferase Assay System (Promega)
Year:
2026
Region / City:
Kolkata, Serampore, Shantiniketan, West Bengal, India
Field:
Pharmacology, Biochemistry, Molecular Biology
Document Type:
Research Article
Institution:
Techno India University, Serampore College, Seacom Skills University
Authors:
Debojyoti Roychowdhury, Partha Talukdar, Soumendra Nath Talapatra
Target Audience:
Researchers in pharmacology, biochemistry, molecular biology, and related fields
Keywords:
Andrographis paniculata, flavonoids, antibacterial properties, molecular docking, bacterial DNA gyrase, phytochemicals, receptor-ligand binding, in silico
Period of Study:
2026
Date of Approval:
2026
Date of Last Revision:
2026
Context:
This research focuses on the molecular docking analysis of flavonoid compounds from Andrographis paniculata to evaluate their antibacterial properties against bacterial DNA gyrase B, suggesting potential alternatives to synthetic antibiotics.
Note:
Year Group
Year:
N/A
Region / City:
N/A
Theme:
Occupational Safety and Health
Document Type:
Procedure
Organization / Institution:
N/A
Author:
N/A
Target Audience:
N/A
Period of Validity:
N/A
Approval Date:
DD.MM.YYYY
Date of Changes:
N/A