№ files_lp_4_process_3_067271
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Record of a laboratory study detailing estrogen receptor transcriptional activation in human HeLa-9903 cells exposed to a test chemical, including methodology, reference compounds, exposure conditions, and assay results under GLP standards.
Year: 2011
Study Type: Estrogen Receptor Transcriptional Activation (Human cell Line, HeLa-9903)
Test Material: [chemical name not specified]
CAS Number: [#]
Purity: [#]%
Sponsor: [Name of Study Sponsor]
Laboratory: [lab], location not specified
PC Code: (if applicable)
DP Barcode: (if applicable)
TXR Number: (if applicable)
Cytotoxicity Method: Not specified
Vehicle: Solvent with final concentration [%]
Reference Substances: 17β-estradiol, 17α-estradiol, Corticosterone, 17α-methyltestosterone
Compliance: GLP, Quality Assurance and Data Confidentiality statements [provided/not provided]
Exposure Duration: 23 ±1 hours
Cell Line: hERα-HeLa-9903
Plate Type: 96-well plate
Incubation Conditions: 37°C, 5% CO₂
Replication: Triplicate wells per concentration
Assay System: Steady-Glo® Luciferase Assay System (Promega)
Price: 8 / 10 USD
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SNMMI Procedure Standard/EANM Practice Guideline for Estrogen Receptor Imaging in Breast Cancer Using [18F]FES PET
Year: 2024
Region / City: International
Subject: Nuclear medicine, breast cancer, estrogen receptor imaging
Document type: Procedure standard / Practice guideline
Organization: SNMMI, EANM
Authors: David Mankoff, Sona Balogova, Lisa Dunnwald, Farrokh Dehdashti, Erik DeVries, Laura Evangelista, Michel Van Krutchen, Sofia Carriho Vaz, Amy Fowler, Hannah Linden, Gary Ulaner
Target audience: Nuclear medicine practitioners, oncologists
Scope period: Current clinical practice
Approval date: 2024
Revision cycle: Every 5 years or sooner if indicated
Description: Clinical guideline detailing standardized procedures for [18F]FES PET imaging of estrogen receptor expression in breast cancer patients, including methodology, interpretation, and quality assurance for diagnostic nuclear medicine.
Supplemental Figure 1. Differential immune cell score analysis by TP53 and HRD status, stratified by estrogen receptor status
Year: 2026
Region / City: N/A
Topic: Immune cell score analysis, TP53 mutation, HRD status, estrogen receptor status
Document type: Figure
Organization / Institution: N/A
Author: N/A
Target audience: Researchers, medical professionals
Period of validity: N/A
Approval date: N/A
Date of modifications: N/A
Supplementary Information TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapy
Year: 2023
Region / City: Not specified
Topic: Mycobacterium tuberculosis, transcriptional regulators, TB therapy
Document type: Research article
Institution: Not specified
Author: Miljan Stupar, Lendl Tan, Edward D. Kerr, Christopher J. De Voss, Brian M. Forde, Benjamin L. Schulz, Nicholas P. West
Target audience: Researchers in microbiology and tuberculosis therapy
Period of action: Not specified
Approval date: Not specified
Date of amendments: Not specified
Methodology: qRT-PCR, PCR screening, CRISPRi, drug susceptibility profiling
Context: A scientific research article detailing the role of the TcrXY transcriptional regulator in Mycobacterium tuberculosis and its potential as a target for improved tuberculosis therapy.
Supplemental Figure Legends: Transcriptional and Epigenetic Analyses of CDX2 and HNF4A in Human and Mouse Gastrointestinal Tissues
Document Type: Supplemental figure legends
Field: Molecular biology
Research Area: Gastrointestinal epithelium and intestinal metaplasia
Subjects: CDX2, HNF4A, SOX2, gastric organoids, Barrett’s esophagus, gastric intestinal metaplasia
Biological Material: Human gastrointestinal tissues and mouse stomach organoids
Methods: Single-cell RNA-seq, bulk RNA-seq, ATAC-seq, CUT&RUN, ChIP-seq, GSEA, enhancer analysis, immunohistochemistry, qRT-PCR
Referenced Studies: Busslinger et al. 2021b; Nowicki-Osuch et al. 2021; Owen et al. 2018; Companioni et al. 2017; Singh et al. 2021; Gao and Kaestner 2010; Wang et al. 2013
Key Topics: Transcriptional profiling, chromatin accessibility, enhancer activity, transcription factor binding, intestinalization of gastric epithelium
Species: Homo sapiens; Mus musculus
Pathological Context: Barrett’s esophagus; gastric intestinal metaplasia
Topics: HeLa-9903 Estrogen transcriptional