M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition

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Year: 2021

Region / City: Rome, Italy

Field: Cancer Research

Document Type: Article

Organization / Institution: Sapienza University of Rome, University of Milan, Consiglio Nazionale delle Ricerche (CNR), University of Trento, University of Ferrara

Authors: Guerriero, Claudia; Manfredelli, Marianna; Matera, Carlo; Iuzzolino, Angela; Conti, Luciano; Dallanoce, Clelia; De Amici, Marco; Trisciuoglio, Daniela; Tata, Ada Maria

Target Audience: Researchers in Cancer Biology

Period of Validity: N/A

Approval Date: N/A

Modification Date: N/A

Keywords: glioblastoma; cancer stem cells; M2 muscarinic receptor; orthosteric and dualsteric muscarinic agonism; autophagy; apoptosis; mTORC1

Funding: Ateneo Sapienza Funds

References: Aoki H, 2008, Autophagy, V4, P467, DOI 10.4161/auto.5668

Context: Scientific article exploring the role of M2 muscarinic receptor stimulation in inducing autophagy and apoptosis in glioblastoma cancer stem cells, and the differential effects of orthosteric and dualsteric agonists.

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mTOR inhibition enhances the antitumor efficacy of RAF dimer-MEK blockade by inhibiting the ATF4-MTHFD2 pathway

Note: Year

Topics: Muscarinic Complex-1 mTOR

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