№ files_lp_4_process_1_39508
File format: docx
Character count: 13840
File size: 2183 KB
Year:
2021-2023
Region / City:
Germany, United Kingdom, Canada
Subject:
Immunology, Chronic Lymphocytic Leukemia
Document Type:
Research supplementary materials
Institution / Organization:
Various academic and research institutions
Authors:
Roessner PM, Llao Cid L, Lupar E, Hanna BS, Ozturk S, Chakraborty S, Martines C, Porro F
Target Audience:
Researchers and clinicians in hematology and immunology
Sample Size:
14 CLL patients
Patient Sex Distribution:
28.6% female (4/14)
Patient Age:
mean 63.3 years, median 59 years
Binet Stage Distribution:
A 64.3% (9/14), B 7.1% (1/14), C 28.6% (4/14)
IGHV Mutational Status:
92.9% mutated (13/14)
Chromosomal Aberrations:
del13q 85.7% (12/14), normal karyotype 14.3% (2/14), del14q 7.14% (1/14)
TP53 Mutation:
0.0% (0/14)
Prior Treatment:
0.0% (0/14)
Methodology:
Flow cytometry, T-cell isolation and activation, proliferation assays, cytotoxicity assays
Animal Models:
Eµ-TCL1 mice, P14xCD4-Cre LCMV TCR-transgenic mice
Reagents and Equipment:
Detailed suppliers and catalog numbers for antibodies, cell isolation kits, dyes, and culture materials
Context:
Experimental research data detailing procedures for isolating, stimulating, and analyzing T cells from CLL patients and murine models using flow cytometry and functional assays.
Price: 8 / 10 USD
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Year:
2023
Region / city:
Australia
Topic:
Oncology, Pharmaceuticals
Document Type:
Resubmission
Institution:
Australian Government, Pharmaceutical Benefits Advisory Committee
Author:
AstraZeneca Pty Ltd.
Target Audience:
Healthcare professionals, regulatory bodies
Effective Period:
Ongoing
Approval Date:
November 2021
Date of Changes:
November 2021
Year:
Not provided
Region / city:
Not provided
Theme:
Hematology
Document type:
Research data
Organization / institution:
Not provided
Author:
Not provided
Target audience:
Healthcare professionals
Period of validity:
Not provided
Approval date:
Not provided
Date of changes:
Not provided
Context description:
Research data presenting characteristics of CLL patients including age, sex, and cytogenetic features.
Year:
Not specified
Region / City:
Not specified
Theme:
Genetics, Oncology
Document Type:
Research Article
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, Scientists, Medical Professionals
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2026
Region:
Laboratory mouse model, C57BL6/KaLwRij
Subject:
Multiple myeloma, osteoblast biology, Runx2 gene function
Document type:
Research supplementary methods
Institution:
Academic research laboratory
Authors:
Not specified
Target audience:
Biomedical researchers, immunologists, oncologists
Experimental period:
Mouse model development and analysis up to 3 months of age
Methods:
Bioluminescence imaging, ELISA, cytokine array, osteoblast isolation and culture, ALP staining, Western blot, cell migration assays, flow cytometry
Genes studied:
Runx2, Samsn1
Cell types:
Osteoblasts, 5TGM1 multiple myeloma cells
Research Field:
Immunology
Subfield:
Host Defense and Sepsis
Experimental Model:
C57BL/6 and C57BL/6J mice
Biological Focus:
Macrophage function and bacterial clearance
Bacterial Species:
Pseudomonas aeruginosa
Laboratory Techniques:
CFU determination, ELISA, flow cytometry, Western blot, siRNA interference, fluorescence microscopy
Cell Type:
Mouse peritoneal macrophages (PMφs)
Tissues Examined:
Lung, liver, spleen, kidney
Biochemical Markers:
ALT, AST, LDH, creatinine
Cytokines and Chemokines Measured:
Prokineticin-2, TNF-α, IL-6, IL-10, IL-17A
Experimental Interventions:
rPK2 stimulation, PKR1/PKR2 siRNA transfection, macrophage depletion with clodronate liposomes
Time Points of Analysis:
24 hours and 48 hours after modeling
Detection Methods:
Hematoxylin-eosin staining, fluorescence microscopy, FACScan flow cytometry, ELISA assays
Software for Analysis:
FCM Express
Referenced Studies:
Song et al., 2016; Song et al., 2015
Animal Age:
Six- to eight-week-old mice
Document type:
Supplementary scientific figures
Field:
Immunology
Research topic:
Dendritic cells, antigen uptake, T cell proliferation, and sarcosine effects in tumor models
Experimental model:
Murine bone marrow–derived dendritic cells (BM-DC) and B16F10-OVA tumor-bearing mice
Biological materials:
FITC-OVA antigen, OVA-mRNA electroporated dendritic cells, sarcosine treated dendritic cells
Methods:
Antigen uptake measurement by mean fluorescence intensity (MFI), in vitro T cell proliferation assay, co-culture experiments, tumor implantation and monitoring
Statistical analysis:
Unpaired t test; two-way ANOVA
Sample size:
n=3; n=5; n=10
Measured indicators:
Antigen uptake (MFI), T cell proliferation percentage, body weight, tumor volume
Experimental comparison groups:
Control BM-DC, untreated BM-DC with OVA-mRNA electroporation, sarcosine treated BM-DC with OVA-mRNA electroporation, sarcosine loaded tumor conditions
Organism:
Mouse
Note:
Year
Author:
Martin Cowie, Saba Mian, Jessica Morris, Roger Newson, Michael Soljak, Bowen Su
Contextual description:
Technical document detailing heart failure prevalence modeling using UK primary care and hospital data, focusing on small populations.
Year:
Not provided
Region / City:
Not specified
Topic:
Research ethics, manuscript submission
Document type:
Template
Author:
Not specified
Target audience:
Authors submitting research articles
Period of validity:
Not provided
Approval date:
Not specified
Date of changes:
Not specified
Year:
Not applicable
Region / City:
Not applicable
Subject:
Research ethics and manuscript submission
Document Type:
Submission Template
Organization / Institution:
Not applicable
Author:
Not applicable
Target Audience:
Researchers, Authors submitting manuscripts
Period of validity:
Not applicable
Approval Date:
Not applicable
Date of Changes:
Not applicable
Author:
Simon Tam
Date:
6th June 2017
Note:
Region
Type of Document:
Workshop Presentation
Institution:
Actuaries Institute
Target Audience:
Actuaries, Data Scientists, Statisticians
Period of Application:
2017
Date of Approval:
6th June 2017
Year:
2026
Region / City:
Global
Topic:
Transboundary river research, Natural Language Processing, Named Entity Recognition, Python
Document type:
Research methodology
Organization / Institution:
None mentioned
Author:
Sahana et al.
Target audience:
Researchers in the field of natural language processing and transboundary river studies
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Year:
2026
Region / City:
Unknown
Theme:
Kinship encoding, Natural Language Processing
Document Type:
Evaluation Report
Organization / Institution:
Unknown
Author:
Unknown
Target Audience:
Researchers in NLP and kinship encoding
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2026
Location:
Cleveland, Ohio
Subject:
Ice Accretion Testing
Document Type:
Research Report
Organization:
NASA Glenn Research Center
Author:
Not specified
Target Audience:
Engineers, researchers in aerospace, and professionals in aviation safety
Effective Period:
Not specified
Approval Date:
Not specified
Date of Modifications:
Not specified
This document describes ice-accretion testing conducted in the NASA Glenn Icing Research Tunnel for three different model configurations:
Inboard, Midspan, and Outboard, with detailed measurements and methods for evaluating ice buildup on aerodynamic surfaces.
Year:
2023
Region / City:
Japan
Topic:
Pulmonary disease, stem cells, regenerative medicine
Document Type:
Research article
Organization / Institution:
Nagasaki University, Tokyo University
Author:
Mayumi Iwatake, Tokiko Nagamura-Inoue, Ryoichiro Doi, Yukinori Tanoue, Mitsutoshi Ishii, Hiroshi Yukawa, Tomoshi Tsuchiya
Target Audience:
Researchers, clinicians in regenerative medicine
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Cell culture:
Human umbilical cord mesenchymal stem cells (UC-MSCs)
Animal model:
C57BL/6 mice
Ethical compliance:
Nagasaki University Institutional Animal Care and Use Committee
Note:
Approval No. 1807101460-2
Year:
2023
Region / City:
United Kingdom
Topic:
Course Assessment Procedures
Document Type:
Policy Guide
Institution:
University
Target Audience:
Academic Staff, Course Administrators, Data Returns Managers
Period of Validity:
Academic Year 2023/2024
Approval Date:
N/A
Date of Changes:
N/A
Year:
2026
Target audience:
Young women and girls
Type of document:
Educational session plan
Theme:
Female role models, empowerment, personal development
Activities:
Group discussions, paired exercises, reflection tasks
Resources:
Articles, videos, podcasts, websites
Duration:
65–75 minutes
Learning objectives:
Explore qualities of good role models, identify relevant role models, reflect on personal potential to inspire others
Organization:
Asia-Pacific Telecommunity
Meeting:
29th Meeting of the APT Wireless Group (AWG-29)
Meeting dates:
21–29 March 2022
Meeting format:
Virtual/Online
Document type:
Draft recommendation
Source reference:
AWG-29/OUT-25
Technical scope:
Fixed Wireless Service link performance under wind conditions
Frequency range discussed:
Millimetre-wave band
Related document:
APT Report No. APT/AWG/REP-81
Annexes:
Attenuation model under wind condition; compensation techniques; link budget evaluation
Date:
29 March 2022
Organization:
Asia-Pacific Telecommunity
Meeting:
29th Meeting of the APT Wireless Group (AWG-29)
Document number:
AWG-29/INP-58
Meeting date:
21–29 March 2022
Document date:
14 March 2022
Meeting format:
Virtual/Online
Submitting organization:
Huawei Technologies Co., Ltd.
Document type:
Working document / proposal
Subject:
Fixed wireless system link performance under wind conditions
Related document:
APT Report No. APT/AWG/REP-81
Frequency range:
Millimetre-wave (85.5 GHz)
Geographical scope:
Asia-Pacific region
Technical focus:
Antenna vibration, wind-induced attenuation models
Context:
Technical working document of a regional telecommunication standardization body outlining proposed models, measurements, and analytical approaches for assessing wind-induced degradation of fixed wireless system link performance.
Year:
2013
Region / City:
Florida
Topic:
Data Administration
Document Type:
Guidelines
Organization / Institution:
Florida Department of Transportation
Author:
Florida Department of Transportation
Target Audience:
FDOT Data Analysts, Developers
Period of Validity:
Not specified
Approval Date:
2/1/2013
Date of Changes:
Not specified
Year:
2016
Organization:
MassHealth
Document type:
Questions and Answers
Topic:
Accountable Care Organization (ACO) program
Audience:
Public, potential bidders
Region:
Massachusetts, USA
Date of release:
September 30, 2016
Related period:
FY17–FY21