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Supplementary scientific data tables presenting measured solubility values of R406 in multiple buffer systems and its in vitro pharmacological activity profile across diverse non-kinase molecular targets using binding and enzyme assays.
Document type: Supplemental data tables
Subject: R406 solubility and in vitro pharmacological profiling
Compound: R406
Experimental context: Pharmacological profiling experiments
Assay types: Radioligand binding assays; isolated enzyme activity assays
Measured parameters: Solubility (µM); pIC50; pKi
Timepoints: 3 hour; 24 hour
Solvent conditions: 0.1%, 0.3%, and 1% DMSO
Buffer systems: Non-kinase buffers; kinase binding buffer; isolated kinase buffers; phosphate-buffered saline
Target scope: Non-kinase targets across enzyme, receptor, ion channel, and transporter classes
Definitions provided: Inactivity threshold defined as pIC50 of 3.5 (<50% inhibition at 10 µM or non-reproducible activity)
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Exam 2 Practice Problems on Chemical Equilibrium, Acid–Base Chemistry, Buffers, Titrations, and Solubility
Year: Not specified
Subject: General Chemistry
Topic: Chemical equilibrium, equilibrium constants, reaction direction, acid–base theory, pH calculations, buffers, titrations, solubility equilibria
Document Type: Practice problem set
Intended Audience: Students preparing for Exam 2
Chemical Systems Covered: Gas-phase equilibria, weak acids and bases, buffer systems, acid–base titrations, sparingly soluble salts
Temperature Conditions Mentioned: 25°C; 30.0°C; 1500 K
Physical Quantities Included: Kc, Ka, Kb, Kw, Ksp, pH, pKa, equilibrium concentrations, molar solubility
Effect of non-linear temperature on the determination of the precise pH of buffers
Year: 2023
Region / city: N/A
Subject: Non-linear temperature effect on buffer solutions
Document type: Research article
Organization / institution: N/A
Author: N/A
Target audience: Researchers in chemistry or related fields
Period of validity: N/A
Approval date: N/A
Date of changes: N/A
Context: A research article exploring how non-linear temperature variations influence the determination of pH in buffer solutions, focusing on thermodynamic and equilibrium considerations.
Supplementary Materials for a Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine
Year: 2021
Region / City: China and Southeast Asia
Subject: Pharmacology, Ethnobotany, Phytochemistry
Document Type: Supplementary material / Scientific review data
Institution: Chengdu University of Traditional Chinese Medicine
Authors: Qinyun Du, Xianli Meng, Shaohui Wang
Target Audience: Researchers and professionals in pharmacology and traditional medicine
Data Coverage: Plant species, pharmacological activities, extraction methods, and chemical properties
Date of Publication: 2021
References Included: Yes, multiple sources cited for plant species and pharmacological effects
Language: English
Document Structure: Tables with plant sources, pharmacological actions, and extraction methods
Kasni (Cichorium intybus Linn.): A Scientific Overview of Traditional and Pharmacological Uses
Year: 2026
Region / city: Global
Subject: Medicinal plants, Traditional medicine, Pharmacology
Document type: Review article
Institution / organization: Unani medicine research institutions
Author: Not specified
Target audience: Researchers, healthcare professionals, students of traditional medicine
Plant profile: Cichorium intybus Linn., including leaves, roots, flowers, and seeds
Pharmacological properties: Hypoglycemic, hypolipidemic, hepatoprotective, gastroprotective, anti-inflammatory, analgesic, antioxidant, antiallergic, antimicrobial
Traditional uses: Liver tonic, digestive aid, deobstruent, blood purifier, mild laxative
Geographical distribution: India, Europe, West Asia, South Africa
Varieties: Bustani (cultivated), Dashti (wild)
Botanical classification: Kingdom Plantae, Family Asteraceae, Genus Cichorium
Keywords: Kasni, Chicory, Coffee substitute, Unani, Therapeutic action, Traditional use
Supplementary Table 1. Search Strategy for Crohn Disease and Pharmacological Interventions (2020–Current)
Document type: Supplementary table
Subject: Crohn disease pharmacological treatment search strategy
Topic: Literature search methodology for inflammatory bowel disease therapies
Disease focus: Crohn disease
Interventions: Tumor necrosis factor inhibitors, monoclonal antibodies, JAK inhibitors, cytokine inhibitors, immunomodulators, aminosalicylates, methotrexate, azathioprine, mercaptopurine
Data sources: MEDLINE, Cochrane Central Register of Controlled Trials (CCTR), Embase
Search fields: Title, abstract, keywords, registry numbers
Search period: 2020–Current
Methodology: Structured database search strategy using controlled vocabulary and keyword combinations
Research context: Identification of studies on pharmacological treatments for Crohn disease
Cardiac resynchronization therapy for enabling guideline-directed pharmacological therapy optimization in heart failure
Year: 2008-2021
Region: Sweden
Topic: Heart failure management and cardiac resynchronization therapy
Document type: Supplemental material / Research tables
Organization: European Society of Cardiology, SwedeHF, NPR, NPDR
Authors: Not specified
Target audience: Cardiologists, researchers, clinicians in cardiology
Data sources: SwedeHF, National Patient Register (NPR), National Prescribed Drug Registry (NPDR), ICD & PM Registry, LISA, RTP
Variables: Demographics, clinical parameters, comorbidities, treatment, socioeconomics
Methodology: Data extraction from registries, calculation of target doses, follow-up analysis
Limitations: Missing data in some variables, assumptions for combination drug dosing
Guideline period: 2008-2021 ESC HF guidelines
Postdoctoral Fellowship Competition in Chemical, Pharmacological, and Bioengineering Fields
Year: 2017
Region / City: New Jersey
Topic: Postdoctoral Fellowship
Document Type: Announcement
Organization: New Jersey Institute of Technology
Author: Not specified
Target Audience: Young scientists with a PhD
Effective Period: N/A
Approval Date: N/A
Amendment Date: N/A
Topics: R406 Buffers Pharmacological