№ files_lp_4_process_3_138934
File format: docx Character count: 33480 File size: 46 KB
Year: 2023
Region / city: Edinburgh, United Kingdom
Topic: HPV, Oropharyngeal Cancer, Liquid Biopsy, Droplet Digital PCR
Document Type: Research Article
Organization / institution: University of Edinburgh, NHS Lothian
Author: Sophie J. Warlow, Martyna Adamowicz, John P. Thomson, Robert A. Wescott, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Lucy Q. Lib, Brendan Conn, Ashley Hay, Iain J. Nixon, Timothy J. Aitman
Target Audience: Researchers, Oncologists, Medical Professionals
Period of Action: Not specified
Date of Approval: Not specified
Date of Changes: Not specified
Description: A research article investigating the use of droplet digital PCR for longitudinal monitoring of HPV copy number in plasma cfDNA for patients with HPV-positive oropharyngeal cancer.
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Performance of ASLC1/LHX8 DNA methylation and extended HPV genotyping in first-void urine for high-grade cervical intraepithelial neoplasia detection in an HPV-positive referral population - a cross-sectional study
Year: 2023
Region / City: Denmark
Theme: Cervical Cancer Screening, HPV Testing, DNA Methylation
Document Type: Research Article
Organization / Institution: University Research Clinic for Cancer Screening, Aarhus University
Authors: Mette Tranberg, Severien Van Keer, Albertus T Hesselink, Pia Nørgaard, Rikke Brøndum, Chunsen WU, Line Winther Gustafson, Anne Hammer, Pinar Bor, Karen Omann Binderup, Christina Blach, Alex Vorsters, Renske Steenbergen
Target Audience: Researchers, Healthcare Professionals, Medical Community
Period of Application: Not specified
Approval Date: Not specified
Date of Changes: Not specified
Study Registration: Clinicaltrials.gov: NCT05065853
Keywords: DNA methylation, cervical cancer screening, HPV DNA testing, urinary HPV testing, early detection of cancer/methods
Abstract: The study evaluates the performance of ASCL1/LHX8 DNA methylation markers and HPV genotyping in first-void urine samples for detecting high-grade cervical intraepithelial neoplasia (CIN2+) and cervical cancer in HPV-positive women, comparing it with clinician-collected cervical samples.
Dysphagia, trismus and speech impairment following radiation-based treatment for advanced stage oropharyngeal carcinoma: a one-year prospective evaluation
Year: 2021
Region / city: Amsterdam, The Netherlands
Topic: Oropharyngeal carcinoma, radiation therapy
Document type: Research article
Institution: Netherlands Cancer Institute, UMC Utrecht Cancer Center
Author: Rebecca T. Karsten, Najiba Chargi, Lisette van der Molen, Rob J.J.H. van Son, Remco de Bree, Abrahim Al-Mamgani, Jan P. de Boer, Frans J.M. Hilgers, Michiel W.M. van den Brekel, Ludi E. Smeele, Martijn M. Stuiver
Target audience: Researchers, medical professionals in oncology and rehabilitation
Period of validity: N/A
Approval date: N/A
Date of changes: N/A
Case Scenario of Two Patients with Oropharyngeal and Pyriform Sinus Squamous Cell Carcinoma
Year: 2026
Patient Demographics: 70-year-old white male; 68-year-old black male
Primary Site: Left pyriform sinus; Right lateral wall of oropharynx
Histology: Squamous cell carcinoma, invasive
Grade/Differentiation: Moderately to poorly differentiated
Clinical Stage: cT2 cN2b cM0 Stage IVA; cT2 N2b M0 Stage IVA
Treatment: Chemoradiation with cisplatin, 70 Gy in 35 fractions for pyriform sinus; 60 Gy in 30 fractions for oropharynx
Imaging: CT Neck, PET/CT, CT Larynx/Neck
Surgical Procedures: Fine needle aspiration, transoral resection, selective neck dissection
Lymph Node Status: Metastatic involvement in cervical and retropharyngeal nodes
Perineural and Lymphovascular Invasion: Present in oropharyngeal tumor
Smoking Status: Current smoker (first patient), smoker (second patient)
Alcohol Use: Current user (first patient), history of alcohol use (second patient)
HPV Status: Positive (first patient)
Topics: HPV-positive cell-free oropharyngeal