№ files_lp_4_process_3_120580
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Clinical case reports describing presentation, imaging, histopathology, surgical findings, and chemoradiation treatment of two male patients with squamous cell carcinoma affecting the oropharyngeal region and pyriform sinus.
Year: 2026
Patient Demographics: 70-year-old white male; 68-year-old black male
Primary Site: Left pyriform sinus; Right lateral wall of oropharynx
Histology: Squamous cell carcinoma, invasive
Grade/Differentiation: Moderately to poorly differentiated
Clinical Stage: cT2 cN2b cM0 Stage IVA; cT2 N2b M0 Stage IVA
Treatment: Chemoradiation with cisplatin, 70 Gy in 35 fractions for pyriform sinus; 60 Gy in 30 fractions for oropharynx
Imaging: CT Neck, PET/CT, CT Larynx/Neck
Surgical Procedures: Fine needle aspiration, transoral resection, selective neck dissection
Lymph Node Status: Metastatic involvement in cervical and retropharyngeal nodes
Perineural and Lymphovascular Invasion: Present in oropharyngeal tumor
Smoking Status: Current smoker (first patient), smoker (second patient)
Alcohol Use: Current user (first patient), history of alcohol use (second patient)
HPV Status: Positive (first patient)
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Dysphagia, trismus and speech impairment following radiation-based treatment for advanced stage oropharyngeal carcinoma: a one-year prospective evaluation
Year: 2021
Region / city: Amsterdam, The Netherlands
Topic: Oropharyngeal carcinoma, radiation therapy
Document type: Research article
Institution: Netherlands Cancer Institute, UMC Utrecht Cancer Center
Author: Rebecca T. Karsten, Najiba Chargi, Lisette van der Molen, Rob J.J.H. van Son, Remco de Bree, Abrahim Al-Mamgani, Jan P. de Boer, Frans J.M. Hilgers, Michiel W.M. van den Brekel, Ludi E. Smeele, Martijn M. Stuiver
Target audience: Researchers, medical professionals in oncology and rehabilitation
Period of validity: N/A
Approval date: N/A
Date of changes: N/A
Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer
Year: 2023
Region / city: Edinburgh, United Kingdom
Topic: HPV, Oropharyngeal Cancer, Liquid Biopsy, Droplet Digital PCR
Document Type: Research Article
Organization / institution: University of Edinburgh, NHS Lothian
Author: Sophie J. Warlow, Martyna Adamowicz, John P. Thomson, Robert A. Wescott, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Lucy Q. Lib, Brendan Conn, Ashley Hay, Iain J. Nixon, Timothy J. Aitman
Target Audience: Researchers, Oncologists, Medical Professionals
Period of Action: Not specified
Date of Approval: Not specified
Date of Changes: Not specified
Description: A research article investigating the use of droplet digital PCR for longitudinal monitoring of HPV copy number in plasma cfDNA for patients with HPV-positive oropharyngeal cancer.
Oral Squamous Cell Carcinoma in Elderly vs Young Patients: Comparative Analysis Using STNMP Staging System (1997–2005)
Year: 2014
Region / city: India
Type of document: Original research article
Field: Oral and maxillofacial pathology
Authors: R Syedmukith, BR Ahmedmujib, TS Bastian
Study period: 1997–2005
Sample size: 75 patients
Age groups: ≤40 years and >40 years
Follow-up duration: 5 years
Staging system: STNMP (site, tumor, node, metastasis, pathology)
Conflict of interest: None
Funding: Nil
Protocol for the Examination of Specimens from Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck
Year: 2022
Region / City: N/A
Topic: Oncology, Pathology
Document Type: Protocol
Organization: CAP (College of American Pathologists)
Authors: Raja R. Seethala, MD; Wonwoo Shon, DO; Bonnie L. Balzer, MD, PhD; Umamaheswar Duvvuri, MD, PhD; Nima M. Gharavi, MD, PhD; William Lydiatt, MD
Intended Audience: Pathologists, Clinical Laboratories, Medical Institutions
Effective Period: From March 2023
Approval Date: September 2022
Amendment Date: N/A
Appendix III: Cancer Immunotherapy Guidelines – Head & Neck Squamous Cell Carcinoma Bibliography (December 17, 2018)
Organization: Society for Immunotherapy of Cancer
Document Type: Bibliography
Subject: Cancer Immunotherapy
Focus: Head and Neck Squamous Cell Carcinoma
Publication Date: December 17, 2018
Date Range of Literature Search: December 1, 2013 – December 17, 2018
Search Limits: Humans, Clinical Trial, Meta-Analysis, Practice Guideline, Randomized Controlled Trial, Review
Therapeutic Agents Covered: Pembrolizumab, Nivolumab, Cemiplimab, Durvalumab
Biomarkers and Targets: PD-1, PD-L1, HPV
Total References Identified: 199
Total Duplicates Removed: 42
Total Records in Bibliography: 157
Topics Included: Immune checkpoint inhibitors, biomarkers, combination immunotherapy, adverse events, toxicity, vaccine, adjuvant and neoadjuvant immunotherapy, rare head and neck cancers
Surgical quality determines the long-term survival superiority of right over left thoracic esophagectomy for localized esophageal squamous cell carcinoma patients: a real-world multicenter study
Year: 2023
Region / City: Not specified
Topic: Thoracic esophagectomy, survival outcomes, esophageal cancer
Document Type: Research article
Institution: Not specified
Author: Not specified
Target Audience: Medical professionals, researchers in oncology
Period of Validity: Not specified
Approval Date: Not specified
Date of Changes: Not specified
Survival Analysis of Esophageal Squamous Cell Carcinoma Patients Using Cox Regression and Kaplan–Meier Curves
Year: 2026
Region: Not specified
Research Field: Oncology
Document Type: Clinical study report
Institution: Not specified
Author: Not specified
Target Population: ESCC patients
Study Period: Not specified
Data Analysis Methods: Univariate and multivariate Cox regression, Kaplan–Meier survival curves, Chi-square test
Variables Analyzed: Age, sex, tumor location, grade, T stage, stage, primary tumor length, tumor types, lymphatic invasion, perineural invasion, lymphangio vascular invasion, postoperative chemotherapy
Survival Outcomes: Overall survival, stratified survival by stage, lymph node status, T stage, and chemotherapy
Statistical Significance Threshold: p < 0.05
Sample Size: 195 patients
Follow-up: Postoperative
Topics: Pyriform oropharyngeal Squamous