№ lp_2_3_36371
File format: docx
Character count: 60299
File size: 4239 KB
Year:
Not specified
Region / City:
Not specified
Theme:
Genetics, Heredity
Document Type:
Educational Unit Plan
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Students of genetics
Period of Action:
Not specified
Approval Date:
Not specified
Date of Modifications:
Not specified
Contextual Description:
Educational unit plan covering Mendelian genetics, its principles, and applications through lessons on heredity, Punnett squares, and genetic disorders.
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Subject:
Genetics
Topic:
Mendelian inheritance
Type of document:
Educational instructional text with worked examples and problem sets
Key concepts:
Monohybrid cross; Dihybrid cross; Sex-linked inheritance; Punnett Square; Genotype and phenotype probabilities
Organisms referenced:
Humans; Guinea pigs; Fruit flies
Genetic traits discussed:
Eye color; Coat texture; Hemophilia; Colorblindness; Distichiasis; Near sightedness
Chromosomes referenced:
X chromosome; Y chromosome
Generations referenced:
Parent generation; F1 generation; F2 generation
Notation conventions:
Dominant and recessive alleles; Haploid and diploid conditions; Probability calculation
Document type:
Reporting guideline checklist
Title:
STROBE-MR checklist of recommended items to address in reports of Mendelian randomization studies
Subject:
Mendelian randomization studies reporting standards
Thematic area:
Epidemiology and genetic epidemiology
Methodological focus:
Instrumental variable assumptions and causal inference
Scope:
Title, abstract, introduction, methods, results, and statistical reporting
Study design context:
Mendelian randomization analysis using GWAS summary statistics
Population described:
European adults with periodontitis and control participants
Data sources:
OpenGWAS database and GWAS Catalog
Statistical software:
R (version 4.3.2), MRPRESSO (1.0), Two Sample MR (0.5.8)
Core assumptions:
Relevance, independence, exclusion restriction
Pre-registration status:
Not reported
Subject:
Genetics
Scientific field:
Mendelian genetics
Document type:
Educational worksheet
Key principles:
Principle of Segregation; Principle of Independent Assortment
Topics:
Monohybrid crosses; Dihybrid crosses; Punnett squares
Genetic traits used in examples:
Freckles (F/f); Color trait green (G) and white (g)
Example parental genotypes:
Ff × Ff; FfGg × FfGg
Genetic concepts referenced:
Alleles; Gametes; Trait inheritance; Heterozygous parents
Educational context:
Classroom genetics exercises
Language:
English
Year:
2023
Country:
China
Ethics Approval Number:
2023KYLL014
Scientific Field:
Genetic epidemiology
Research Topic:
Causal relationship between chronic obstructive pulmonary disease and lung adenocarcinoma
Study Design:
Two-sample Mendelian randomization study
Document Type:
Reporting checklist
Exposure:
Chronic obstructive pulmonary disease (COPD)
Outcome:
Lung adenocarcinoma (LUAD)
Data Sources:
GWAS dataset ebi-a-GCST90018807; GWAS dataset ebi-a-GCST004744; TCGA; GEO datasets GSE116959 and GSE76925
Sample Size:
57 LUAD patients, 11 healthy controls, 111 COPD cases, 40 smoking controls
Key Biomarkers:
FCRLA, GREM1, MMP9
Statistical Methods:
Inverse variance weighting (IVW), MR Egger, MR-PRESSO, LASSO regression, false discovery rate correction
Software:
R version 4.2.1; TwoSampleMR package; ggplot2
Diagnostic Criteria:
COPD defined by spirometry (FEV1/FVC < 0.7); LUAD confirmed by histopathology
Genetic Variant Selection Criteria:
Genome-wide significance threshold p < 5 × 10⁻⁸; LD pruning r² < 0.01
Core Mendelian Randomization Assumptions:
Relevance, independence, exclusion restriction
Document type:
Supplementary material
Scientific field:
Genetic epidemiology
Research topic:
Mendelian randomization analysis of smoking initiation, body mass index, lymphocyte count, and osteomyelitis
Content type:
Statistical tables and figures
Statistical methods:
IVW, MR Egger, Simple mode, Weighted median, Weighted mode, Lasso, Median
Data elements:
SNPs, beta coefficients, standard errors, confidence intervals, odds ratios, P values
Exposure variables:
Smoking initiation; Body mass index; Lymphocyte count
Outcome variables:
Lymphocyte count; Osteomyelitis; Body mass index; Smoking initiation
Mediator variable:
Lymphocyte count
Analysis types:
Mendelian randomization; Reverse MR analysis; Multivariable MR analysis; Mediation analysis; Sensitivity analysis
Genetic instruments:
Single nucleotide polymorphisms (SNPs)
Tables included:
Supplementary Tables 1–5
Figures included:
Supplementary Figures 1–2
Year:
2021
Type of document:
Reporting guideline
Topic:
Mendelian randomization, epidemiology
Organization:
Equator Network
Authors:
Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, et al.
Target audience:
Researchers conducting Mendelian randomization studies
License:
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
Data availability:
Described in the checklist; code and data sources referenced
Funding:
Detailed in the original checklist publication
Conflicts of interest:
Declared by all authors
Context:
Reporting guideline providing a structured checklist of items to include when publishing Mendelian randomization studies, detailing study design, methods, results, and interpretation.
Year:
2023
Region / City:
Not specified
Subject:
Mendelian Randomization analysis of metabolites
Document Type:
Research Data
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers in the field of genetic epidemiology
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Last Update:
Not specified
Note:
Year
Topic:
Genetics, Mendelian Inheritance
Document Type:
Procedure
Target Audience:
Students
Related Terms:
Mendel’s Laws, Segregation, Independent Assortment, Inheritance
Procedure:
Experiment, Genetic Analysis
Experiment Type:
Hands-on, Genetics Education
Subject:
Genetics and heredity
Academic field:
Biology
Topic:
Mendelian genetics and inheritance patterns
Type of document:
Educational text with explanations and practice exercises
Educational level:
Introductory biology / basic genetics
Key concepts:
heredity, genes, alleles, genotype, phenotype, dominant and recessive traits
Scientific figure discussed:
Johann Gregor Mendel
Biological organisms mentioned:
pea plants, beetles, coniferous trees, mushrooms, butterflies, bacteria
Historical period referenced:
mid-19th century research on inheritance
Educational purpose:
explanation of genetic inheritance and practice with genotype–phenotype relationships
Examples and exercises:
pea plant inheritance experiment and genotype tables
Year:
2020
Region / City:
N/A
Topic:
Mendelian Randomization, Mental Health, Substance Use
Document Type:
Supplementary Material
Organization / Institution:
N/A
Authors:
Jorien L Treur, Marcus R Munafò, Emma Logtenberg, Reinout W Wiers, Karin Verweij
Target Audience:
Researchers, Academics, Healthcare Professionals
Effective Period:
N/A
Date of Approval:
N/A
Date of Changes:
N/A
Note:
Description
Year:
2003
Region / City:
-
Topic:
Genetics
Document Type:
Worksheet
Author:
T. Trimpe
Target Audience:
Students
Period of Validity:
-
Approval Date:
-
Date of Changes:
-
Year:
2020
Region / city:
South East Scotland
Field:
Genetics
Document type:
Job Description
Organization:
NHS Lothian
Author:
Not specified
Target audience:
Healthcare professionals
Effective period:
Not specified
Approval date:
January 2020
Date of changes:
Not specified
Year:
2024
Region / City:
United States
Topic:
Medical Education, Training Programs
Document Type:
Guidelines
Institution:
The American Board of Obstetrics and Gynecology, The American Board of Medical Genetics and Genomics
Author:
N/A
Target Audience:
Program Directors, Medical Institutions, Trainees
Effective Period:
Ongoing
Approval Date:
February 2024
Modification Date:
N/A
Year:
2026
Region / City:
Not specified
Topic:
Research Funding, Academic Support
Document Type:
Application Guidelines
Organization:
Division of Diagnostics Genetics & Genomics (DGG)
Author:
Not specified
Target Audience:
Faculty members in the field of Diagnostic Genetics & Genomics
Period of Activity:
Ongoing
Approval Date:
Not specified
Amendment Date:
Not specified
Year:
2023
Region / city:
Northern Arizona
Subject:
Genetics, Microbial Research
Document Type:
Protocol
Institution:
Northern Arizona University, College of Engineering, Forestry and Natural Sciences, School of Forestry and Center for Microbial Genetics and Genomics
Author:
Northern Arizona University
Target Audience:
Researchers in microbial genetics, field biologists
Period of validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Context:
Protocol for collecting guano samples for genetic analysis, detailing materials and procedures for field sampling and preservation.
Year:
2023
Region / City:
Muncie, IN
Topic:
Genetics of Communication Disorders
Document Type:
Course Syllabus
Institution:
Ball State University
Author:
Lauren A. Shaffer, Ph.D., CCC-A
Target Audience:
Graduate students in audiology or speech-language pathology
Period of Validity:
Fall 2023
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2021
Region / city:
Coimbatore
Subject:
Tender notice
Document Type:
Tender
Organization / institution:
Bharathiar University
Author:
Registrar
Target audience:
Firms specializing in scientific equipment
Period of validity:
180 days from tender opening
Approval date:
30.11.2021
Modification date:
N/A
Year:
2014
Region / City:
N/A
Topic:
Genetics and Traits
Document Type:
Lesson Plan
Organization / Institution:
N/A
Author:
Mrs. Gilley
Target Audience:
Students
Period of Effectiveness:
October 6-7, 2014
Approval Date:
N/A
Revision Date:
N/A