№ files_lp_4_process_3_072565
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This document contains the heterogeneity test results for Mendelian Randomization analyses involving metabolites associated with diabetic foot ulcers (DFUs).
Year:
2023
Region / City:
Not specified
Subject:
Mendelian Randomization analysis of metabolites
Document Type:
Research Data
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers in the field of genetic epidemiology
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Last Update:
Not specified
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2015
Region / City:
N/A
Topic:
Clinical Trials, Randomization, Blinding
Document Type:
Standard Operating Procedure (SOP)
Organization / Institution:
N/A
Author:
N/A
Target Audience:
Clinical Trial Personnel, Investigators
Period of Validity:
Indefinite
Approval Date:
01/01/2015
Effective Date:
01/01/2015
Revision Date:
06/01/2016
Year:
202x
Region / city:
Not specified
Topic:
Ecological study, Edge Influence
Document type:
Program Instructions
Organization / institution:
Not specified
Author:
Harper, Karen A. and Macdonald, S. Ellen
Target audience:
Researchers in ecology, particularly those studying edge influence
Period of validity:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Document type:
Reporting guideline checklist
Title:
STROBE-MR checklist of recommended items to address in reports of Mendelian randomization studies
Subject:
Mendelian randomization studies reporting standards
Thematic area:
Epidemiology and genetic epidemiology
Methodological focus:
Instrumental variable assumptions and causal inference
Scope:
Title, abstract, introduction, methods, results, and statistical reporting
Study design context:
Mendelian randomization analysis using GWAS summary statistics
Population described:
European adults with periodontitis and control participants
Data sources:
OpenGWAS database and GWAS Catalog
Statistical software:
R (version 4.3.2), MRPRESSO (1.0), Two Sample MR (0.5.8)
Core assumptions:
Relevance, independence, exclusion restriction
Pre-registration status:
Not reported
Year:
2023
Country:
China
Ethics Approval Number:
2023KYLL014
Scientific Field:
Genetic epidemiology
Research Topic:
Causal relationship between chronic obstructive pulmonary disease and lung adenocarcinoma
Study Design:
Two-sample Mendelian randomization study
Document Type:
Reporting checklist
Exposure:
Chronic obstructive pulmonary disease (COPD)
Outcome:
Lung adenocarcinoma (LUAD)
Data Sources:
GWAS dataset ebi-a-GCST90018807; GWAS dataset ebi-a-GCST004744; TCGA; GEO datasets GSE116959 and GSE76925
Sample Size:
57 LUAD patients, 11 healthy controls, 111 COPD cases, 40 smoking controls
Key Biomarkers:
FCRLA, GREM1, MMP9
Statistical Methods:
Inverse variance weighting (IVW), MR Egger, MR-PRESSO, LASSO regression, false discovery rate correction
Software:
R version 4.2.1; TwoSampleMR package; ggplot2
Diagnostic Criteria:
COPD defined by spirometry (FEV1/FVC < 0.7); LUAD confirmed by histopathology
Genetic Variant Selection Criteria:
Genome-wide significance threshold p < 5 × 10⁻⁸; LD pruning r² < 0.01
Core Mendelian Randomization Assumptions:
Relevance, independence, exclusion restriction
Year:
2017
Region / city:
Not specified
Field:
Statistical analysis, Experimental methods
Document type:
Research table
Author:
Duma et al., D’León & Izara, Jolii & Bierman, Kittenis, May & Spoottiswoode, McCraty, Mossbridge, Radin et al., Rezaei, Singh, Savva, Siller et al., Silva, Tressoldi
Target audience:
Researchers, scientists in experimental psychology and statistics
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Note:
Summary
Document type:
Supplementary material
Scientific field:
Genetic epidemiology
Research topic:
Mendelian randomization analysis of smoking initiation, body mass index, lymphocyte count, and osteomyelitis
Content type:
Statistical tables and figures
Statistical methods:
IVW, MR Egger, Simple mode, Weighted median, Weighted mode, Lasso, Median
Data elements:
SNPs, beta coefficients, standard errors, confidence intervals, odds ratios, P values
Exposure variables:
Smoking initiation; Body mass index; Lymphocyte count
Outcome variables:
Lymphocyte count; Osteomyelitis; Body mass index; Smoking initiation
Mediator variable:
Lymphocyte count
Analysis types:
Mendelian randomization; Reverse MR analysis; Multivariable MR analysis; Mediation analysis; Sensitivity analysis
Genetic instruments:
Single nucleotide polymorphisms (SNPs)
Tables included:
Supplementary Tables 1–5
Figures included:
Supplementary Figures 1–2
Year:
2021
Type of document:
Reporting guideline
Topic:
Mendelian randomization, epidemiology
Organization:
Equator Network
Authors:
Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, et al.
Target audience:
Researchers conducting Mendelian randomization studies
License:
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
Data availability:
Described in the checklist; code and data sources referenced
Funding:
Detailed in the original checklist publication
Conflicts of interest:
Declared by all authors
Context:
Reporting guideline providing a structured checklist of items to include when publishing Mendelian randomization studies, detailing study design, methods, results, and interpretation.
Year:
2020
Region / City:
N/A
Topic:
Mendelian Randomization, Mental Health, Substance Use
Document Type:
Supplementary Material
Organization / Institution:
N/A
Authors:
Jorien L Treur, Marcus R Munafò, Emma Logtenberg, Reinout W Wiers, Karin Verweij
Target Audience:
Researchers, Academics, Healthcare Professionals
Effective Period:
N/A
Date of Approval:
N/A
Date of Changes:
N/A
Note:
Description
Study design:
Experimental in-vitro study
Place and Duration of Study:
Centre for Bioscience and Nanoscience Research; May to July 2025
Organism studied:
Trichoderma viride
Type of document:
Research article
Methodology:
Solvent extraction; Thin Layer Chromatography (TLC); Column Chromatography; UV-Visible Spectroscopy; agar well diffusion assay; MTT assay
Culture media:
MGYP broth; Malt agar (Himedia, India)
Analytical techniques:
Thin Layer Chromatography; Column Chromatography; UV-Visible Spectroscopy
Test organisms:
Staphylococcus aureus; Klebsiella pneumoniae
Cell line:
MCF-7 breast cancer cell line
Keywords:
UV-Visible spectroscopy; antibacterial activity; anticancer activity; Thin layer chromatography; column chromatography
Year:
2023
Region / City:
Jiangsu, China
Topic:
Environmental Science, Agriculture
Document Type:
Research Article
Organization / Institution:
Jiangsu Academy of Agricultural Sciences, Jiangsu University, Jinan University, Yancheng Institute of Technology
Authors:
Pei Chen, Yu Cheng, Ning Wang, Jian-Guang Yu, Zhao Ying, Li-Hong Xue
Target Audience:
Academics, Environmental Scientists, Agricultural Researchers
Period of validity:
N/A
Approval Date:
N/A
Date of changes:
N/A
Year:
2021
Region / city:
Niger Delta, Bayelsa, Nigeria
Subject:
Toxicology, Aquatic Biology
Document Type:
Research Article
Organization / institution:
Bayelsa Medical University, Niger Delta University
Authors:
Patani Dudutari Edmund, Inyang Iniobong Reuben
Target audience:
Researchers, Environmental Scientists, Biologists
Study period:
2021
Approval Date:
Not stated
Date of changes:
Not stated
Year:
Not specified
Document Type:
Supplementary information
Subject:
Quantitative analysis of acetaminophen and metabolites in plasma
Analytes:
APAP, APAP-G, APAP-S, APAP-C, APAP-NAC, APAP-SG
Biological Matrices:
Rat plasma; pig plasma; human plasma
Analytical Method:
U(H)PLC-MS
Institutions:
Imperial College London; GlaxoSmithKline R&D; AstraZeneca; Royal Veterinary College; UCL Institute for Liver and Digestive Health
Geographical Location:
London; Ware; Cambridge; Hertfordshire, United Kingdom
Content Elements:
Calibration curve preparation; quality control samples; stock solution preparation; internal standard preparation; validation data
Validation Scope:
Rat plasma method validation over three days
Tables Included:
S1–S8
Document type:
Supplementary table
Study population:
Virally suppressed women with HIV (VS-WWH) and women without HIV (WWH)
Subject:
Associations between cognitive domains and tryptophan–kynurenine metabolites
Biomarkers:
Kynurenine, Tryptophan, KT Ratio
Statistical method:
Spearman’s partial correlation
Statistical measures:
Correlation coefficient (r), p-value
Controlled variables:
Smoking status, days between neuropsychological testing and metabolite draw, fasting status at metabolite draw, BMI, sCD14
Health condition:
Human immunodeficiency virus (HIV)
Cognitive domains assessed:
Motor, Processing Speed, Attention/Working Memory, Verbal Fluency, Verbal Learning, Verbal Memory, Executive Function
Table designation:
Supplementary Table 2
Year:
2026
Institution:
Singapore Institute of Food and Biotechnology Innovation, A*STAR
Authors:
Pnelope Ng, Leng Wei Khoo, Aaron Thong, Wee Chew
Corresponding author:
Wee Chew, [email protected]
Field:
Metabolomics, Analytical Chemistry, Microbial Biotechnology
Document type:
Research article
Target organism:
Engineered Escherichia coli
Analytical technique:
LC-ToF-MS
Method focus:
Extraction optimization using statistical experimental design (DoE)
Validation standards:
Metabolomics Standards Initiative, ICH Q2 (R1)
Keywords:
Mevalonate pathway, LC-ToF-MS, Extraction, Design of experiment, Engineered E. coli
Publication date:
2026
Year:
2026
Region:
Global
Topic:
Plant disease management
Document type:
Review article
Institution:
Agricultural research and academic publications
Author:
Not specified
Target audience:
Researchers, agronomists, and plant pathologists
Active period:
Current agricultural practices
Keywords:
Mushroom metabolite, Lentinan, Schizophyllan, GL polysaccharides, Pleurotin, Plant immunity, Biopesticides
Field of application:
Sustainable agriculture and biofungicide development
Year:
Not specified
Region / Location:
Machilipatnam, Andhra Pradesh, India
Ecosystem:
Mangrove ecosystem
Scientific Field:
Microbiology; Biotechnology; Natural Products Research
Research Topic:
Optimization of culture conditions for antimicrobial metabolite production
Type of Document:
Scientific research article
Subject Organism:
Streptomyces cinnamonensis VLCH-1
Source of Isolation:
Mangrove sediment samples
Research Methods:
Isolation of actinobacteria, culture media optimization, incubation parameter analysis, antimicrobial activity assays
Test Microorganisms:
Staphylococcus aureus, Bacillus megaterium, Streptococcus mutans, Escherichia coli, Xanthomonas campestris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Penicillium citrinum
Culture Media Examined:
ISP-1, ISP-2, ISP-3, ISP-4, ISP-5, Nutrient broth, Czapek-Dox medium
Optimal Medium Identified:
ISP-2 (yeast extract malt extract dextrose broth)
Incubation Conditions Studied:
Temperature, pH, incubation time
Keywords:
Mangrove ecosystem, Streptomyces cinnamonensis VLCH-1, optimization, bioactive secondary metabolites