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The document provides detailed supplementary data for a study on the solubility of KME in various excipients, including particle size, loading efficiency, and modeling results for in vitro release and transport studies.
Year: 2026
Region / city: N/A
Subject: Solubility and microemulsion properties of KME
Document type: Research Supplementary Material
Institution: N/A
Author: N/A
Target audience: Researchers in pharmaceutical sciences
Period of validity: N/A
Approval date: N/A
Date of changes: N/A
Price: 8 / 10 USD
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Preparation and Evaluation of Erythromycin Microemulsion for Ophthalmic Drug Delivery
Type of document: Research study abstract and introduction
Field: Pharmaceutics
Topic: Ocular drug delivery
Drug studied: Erythromycin
Drug class: Macrolide antibiotic
Dosage form: Microemulsion
Oil phase: Oleic acid
Surfactant: Tween 80
Co-surfactant: Ethanol
Aqueous phase: 0.5 N NaOH
Experimental design: 2³ factorial design
Evaluated parameters: Particle size, viscosity, pH, drug content
Particle size range: 12.11–650.6 nm
Drug content range: 79.55%–95.56%
Optimized formulation: F1
Keywords: Microemulsion, Ocular delivery, Surfactant, Amphiphile, Conjunctivitis, Evaluation
Solubility Equilibria and Solubility Product Calculation
Year: Not specified
Region / city: Not specified
Subject: Chemistry, Solubility Equilibria
Document type: Educational text
Author: Not specified
Target audience: Students of chemistry, possibly in higher education
Effective period: Not specified
Approval date: Not specified
Modification date: Not specified
Acid Titration and Solubility Quiz
Year: 2026
Subject: Chemistry
Type of Document: Quiz
Author: Unknown
Target Audience: Students studying chemistry
Relevant Chapter: 17
Topics: Acid-Base Titration, Solubility, Ka, pH, pOH
Institution: Educational/Academic
Date of Approval: N/A
Date of Revision: N/A
Exam 2 Practice Problems on Chemical Equilibrium, Acid–Base Chemistry, Buffers, Titrations, and Solubility
Year: Not specified
Subject: General Chemistry
Topic: Chemical equilibrium, equilibrium constants, reaction direction, acid–base theory, pH calculations, buffers, titrations, solubility equilibria
Document Type: Practice problem set
Intended Audience: Students preparing for Exam 2
Chemical Systems Covered: Gas-phase equilibria, weak acids and bases, buffer systems, acid–base titrations, sparingly soluble salts
Temperature Conditions Mentioned: 25°C; 30.0°C; 1500 K
Physical Quantities Included: Kc, Ka, Kb, Kw, Ksp, pH, pKa, equilibrium concentrations, molar solubility
Lesson Plan for Unit 3: Solutions and Solubility - Review
Grade: 11 University
Course: SCH 3U
Unit: Solutions and Solubility
Topic: Review
Date: Not provided
Learning Expectations: Overall and Specific Expectations
Teacher Resources: Laptop, LCD Projector, Chalk, Chalkboard
Student Resources: Pen, Pencil, Calculator, Textbook
Teaching/Learning Strategies: Note taking, Problem solving
Accommodations/Modifications: Assisted note, PowerPoint presentation, Note posted online
Assessment & Evaluation: Student questions checked for completion
Key Ideas: Polar and non-polar molecules, Electronegativity, Hydrogen bonds, Ionic and molecular compounds in water, Solution concentrations, Molar concentrations, Solubility of solids, liquids, and gases, Temperature, Pressure, Double displacement reactions, Acids and bases, Ionization, pH and ion concentration, Neutralization reactions, Titrations
Context: A lesson plan focusing on a review of the topics covered in a chemistry unit about solutions and solubility for grade 11 students.
Chemistry Practice Review: Naming and Writing Formulas, Solubility, Reactions, and Balancing Equations
Subject: Chemistry
Topic: Chemical nomenclature, formula writing, solubility rules, reaction prediction, equation balancing, reaction classification
Document Type: Educational worksheet
Educational Level: Secondary education
Number of Questions: 70
Skills Assessed: Compound naming, formula writing, solubility determination, precipitate identification, balancing equations, reaction classification, product prediction
Language: English
Supplemental Data Tables on R406 Solubility in Buffers and In Vitro Pharmacological Profile
Document type: Supplemental data tables
Subject: R406 solubility and in vitro pharmacological profiling
Compound: R406
Experimental context: Pharmacological profiling experiments
Assay types: Radioligand binding assays; isolated enzyme activity assays
Measured parameters: Solubility (µM); pIC50; pKi
Timepoints: 3 hour; 24 hour
Solvent conditions: 0.1%, 0.3%, and 1% DMSO
Buffer systems: Non-kinase buffers; kinase binding buffer; isolated kinase buffers; phosphate-buffered saline
Target scope: Non-kinase targets across enzyme, receptor, ion channel, and transporter classes
Definitions provided: Inactivity threshold defined as pIC50 of 3.5 (<50% inhibition at 10 µM or non-reproducible activity)
Exploiting hybrid modelling strategies for predicting intestinal solubility
Year: 2023
Region / City: Padova, Italy
Topic: Pharmaceutical Development, Drug Solubility
Document Type: Research Study
Organization / Institution: University of Padova, GlaxoSmithKline
Author: Marco Brendolan, Francesca Cenci, Konstantinos Stamatopoulos, Fabrizio Bezzo, Pierantonio Facco
Target Audience: Pharmaceutical Researchers, Bioengineers
Period of Validity: N/A
Approval Date: N/A
Date of Changes: N/A
Factors affecting solubility and solution calculations
Year: 2026
Region / City: Not specified
Subject: Chemistry
Document Type: Educational worksheet
Institution / Organization: Not specified
Author: Not specified
Target Audience: Students
Topics Covered: Solubility, gas laws, molarity, molality, solution preparation, dilution
Formulas Included: Henry’s Law, Molarity, Molality, Dilution calculations
Exercises: Quantitative problems on solubility and solution concentrations
Supporting Information for Influence of changes in pH and temperature on the distribution of apparent iron solubility in the ocean
Year: 2021
Region / City: Global
Topic: Ocean biogeochemistry, Iron solubility
Document type: Research Supplement
Organization / Institution: GEOMAR Helmholtz Center for Ocean Research Kiel, Bermuda Institute of Ocean Science, University of Southampton, NIOZ, Southern University of Science and Technology
Authors: Kechen Zhu, Eric P. Achterberg, Nicholas R. Bates, Loes J. A. Gerringa, Rob Middag, Mark J. Hopwood, Martha Gledhill
Target audience: Researchers, oceanographers
Period of validity: 2021
Approval date: Not specified
Date of changes: Not specified
Note: Context
Topics: KME Microemulsion Solubility