№ files_lp_4_process_3_126919
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Evaluation of cytotoxicity of 16 selected compounds in cryopreserved human hepatocytes using different culture formats to compare their predictive value for drug-induced liver injury.
Year: 2026
Region / City: International (France, Belgium, UK, Germany, Finland)
Topic: Drug-induced liver injury (DILI) assessment
Document Type: Research article
Institution / Organization: KaLy-Cell, UCB BioPharma, MRC Centre for Drug Safety Science, Sanofi-Aventis, GlaxoSmithKline, Orion Corporation, AstraZeneca, Université de Franche-Comté
Authors: Lysiane Richert, Audrey Baze, Céline Parmentier, Helga Gerets, Rowena Sison-Young, Martina Dorau, Cerys Lovatt, Andreas Czich, Christopher Goldring, Kevin Park, Satu Juhila, Alison J. Foster, Dominic Williams
Funding: IMI MIP-DILI project (Grant Agreement number 115336)
Target Audience: Researchers in pharmacology and toxicology
Methodology: Comparative in vitro cytotoxicity assays using 2D and 3D human hepatocyte cultures
Compounds Tested: 16 training compounds (12 DILI-positive, 4 non-DILI)
Exposure Periods: 2 hours (suspension), 3 days (2D-sw), 14 days (3D-MT co-culture)
Endpoints: DILI prediction accuracy, sensitivity, and specificity
Abbreviations: DILI, NPC, 2D-sw, SM, MT, TC
Price: 8 / 10 USD
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QUALITY TECHNICAL AGREEMENT FOR THE RECEIPT, STORAGE, AND ONWARD SUPPLY OF CRYOPRESERVED ADVANCED THERAPY MEDICINAL PRODUCTS (ATMPs) which hold a marketing authorisation (MA)
Note: Year
Document Type: Quality Technical Agreement
Supplementary figures for macrophage viability and cytotoxicity in response to crystalline silica exposure and immune stimulation
Year: 2023
Region / City: Not specified
Topic: Immunology, Cytotoxicity, Flow Cytometry
Document Type: Research Supplementary Figures
Author: Not specified
Target Audience: Researchers, Immunologists
Period of Validity: Not specified
Approval Date: Not specified
Modification Date: Not specified
Supplementary Data on the Effects of CA9 and NHE1 on NK-92 Cell Cytotoxicity and Gene Expression
Year: 2026
Research Institution: Unspecified biomedical research laboratory
Type of Document: Supplementary data for a scientific study
Subject: NK-92 cell cytotoxicity, CA9, NHE1, gene expression profiling
Organism / Cell Line: Human melanoma cell lines WM3629, WM1727A, WM4237; NK-92 and NK-92MI cells
Methods: In vitro cytotoxicity assays, immunoblotting, confocal microscopy, mRNA sequencing
Key Genes / Proteins: CA9, NHE1, c-Myc, SCO2, ITGB1P1, TRIM9, SVIL, KDM5B, S100A8, NTRK2, SMAD3, MYO1E, FMNL2, GABRB3, RBM41, P2RX5, PDGFRL
Experimental Conditions: pH-controlled media, empty vector controls, constitutively active NHE1, NHE1-E262I mutant
Data Type: Figures S1–S5, Tables S1–S2
Statistical Analysis: Two-way ANOVA, unpaired t-test
FTO attenuates the cytotoxicity of cisplatin on KGN cells by regulating the Hippo/YAP1 signaling pathway
Year: 2026
Topic: Cellular biology, cancer research, ovarian failure
Document Type: Research article
Author: Rongli Wang, Xinyuan Yang
Target Audience: Researchers, medical professionals
Period of Action: N/A
Approval Date: N/A
Modification Date: N/A
Topics: hepatocytes CRYOPRESERVED cytotoxicity