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Scientific research article presenting population-based genetic and lipid data from the UK Biobank to examine the prevalence of pathogenic familial hypercholesterolaemia variants and their association with LDL-C concentrations across European, South Asian, and African ancestry groups.
Authors: Jasmine Gratton; Steve E Humphries; Marta Futema
Institutions: Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom; Cardiology Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London, United Kingdom
Country: United Kingdom
Data source: UK Biobank
Study design: Population-based cohort study
Subject: Prevalence of FH-causing genetic variants and association with LDL-C levels across ancestry groups
Population: European, South Asian, and African ancestry participants
Sample size: 140,439 European; 4,067 South Asian; 3,906 African participants with lipid and whole exome sequencing data
Genes analysed: LDLR; APOB; PCSK9
Methods: Principal component analysis; whole exome sequencing; variant classification using ACMG guidelines
Outcome measures: Prevalence of pathogenic and likely pathogenic FH variants; LDL-C concentration adjusted for statin use; prevalence and incidence of coronary heart disease
Period of data collection: 2006–2010
Ethical approval: Conducted under approved UK Biobank application 40721
Type of document: Scientific research article
Price: 8 / 10 USD
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Kaplan-Meier Curves for MACCEs Based on High-Risk Threshold Values of hs-CRP and LDL-C
Year: 2023
Region / City: N/A
Subject: Medical Research
Document Type: Research Supplementary Figures
Institution: N/A
Author: N/A
Target Audience: Medical Professionals
Action Period: N/A
Approval Date: N/A
Date of Changes: N/A
Context: A set of supplementary figures for a study on the risk of Major Adverse Cardiovascular and Cerebrovascular Events (MACCEs) based on high-risk threshold values of hs-CRP and LDL-C, categorizing patients by these values and analyzing survival outcomes.
Shared Ancestry of Jews and Palestinians: A Genetic and Historical Analysis
Year: 2020
Region / city: Levant
Topic: Genetics, History
Document type: Academic paper
Organization / institution: Various genetic studies, Biblical Archaeology Review
Author: Multiple authors
Target audience: Scholars, researchers, students
Period of validity: Not specified
Date of approval: Not specified
Date of changes: Not specified
Note: Contextual description
Mixed ancestry of Europeans who settled Iceland and Greenland: 3D geometric-morphometric analyses of cranial base shape
Section: Research
Field: Archaeology
Subfield: Geometric morphometrics
Topic: Cranial base shape and population ancestry
Authors: Kimberly A. Plomp; Keith Dobney; Hildur Gestsdóttir; Mark Collard
Corresponding authors: Kimberly A. Plomp; Mark Collard
Institutions: University of the Philippines Diliman; Simon Fraser University; University of Sydney; University of Aberdeen; Institute of Archaeology, Reykjavik
Geographical focus: Iceland; Greenland; Scandinavia; British Isles
Sample groups: Greenlandic; Scandinavian; southern British; Scottish and Irish
Methods: Photogrammetry; 3D modelling; landmark-based geometric morphometrics; Generalised Procrustes Analysis; Principal Components Analysis; Canonical Variates Analysis; Linear Discriminant Analysis; MANOVA
Software: Agisoft Metashape (2019 edition); MorphoDig; Morphologika; MorphoJ; R
Landmarks recorded: 34 cranial base and temporal bone landmarks
Data collection: XYZ coordinates recorded from 3D cranial models
Intra-observer error assessment: Repeated digitisation and Procrustes distance comparison
Analytical framework: Operational Taxonomic Units (OTUs) and comparative shape analysis
References cited: Evin et al. (2013, 2015, 2016); Harvati & Weaver (2006); Bookstein (1991); Neubauer et al. (2009, 2010); Klingenberg (2011); Slice (2007); O’Higgins & Jones (2006); Plomp et al. (2021)
Supplementary Table 1. Rare germline pathogenic, likely pathogenic, or deleterious (P/LP/D) variants (n=51) in BRCA2, ATM, NBN, and PALB2 identified among men of African ancestry.
Note: Gene
Year: 2020
Region / city: Not specified
Topic: Genetic variants, Germline mutations
Document type: Supplementary Table
Author: Matejcic et al
Target audience: Researchers in genetics, oncology
Period of validity: Not specified
Approval date: Not specified
Modification date: Not specified
Robert HYDE of Hyde’s Coffee Shop and the Ancestry of Rev. William JACKSON
Year: 1795
Location: Dublin, Ireland
Subject: History of Hyde’s Coffee Shop and the Jackson Family
Document Type: Historical account / genealogical notes
Author: Richard Jackson
Related Individuals: Rev. William JACKSON, Robert HYDE, Luke NAYLOR, Anne FARRELL, Dr. Richard JACKSON
Historical Events: Arrest of Rev. William JACKSON for treason, establishment of Hyde’s Coffee Shop
Primary Sources: Newspaper advertisements, leases, historical records
Publication Year: 2019–2023
Period Covered: 1749–1795
Purpose: Documenting family connections and the establishment of Hyde’s Coffee Shop
Topics: Hypercholesterolaemia-Causing LDL-C Ancestry