№ lp_2_3_19202
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The document contains detailed clinical data from a cohort of patients treated for organ-specific conditions and monitors survival and response outcomes over specified time periods.
Year:
2023
Region / City:
Global
Subject:
Clinical Trial / Treatment Response
Document Type:
Clinical Data Report
Organization / Institution:
[Not specified in the document]
Author:
[Not specified in the document]
Target Audience:
Medical professionals, researchers, healthcare providers
Effective Period:
[Not specified in the document]
Approval Date:
[Not specified in the document]
Amendment Date:
[Not specified in the document]
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2019
Region / City:
Wellington, New Zealand
Topic:
Colorectal cancer, chemotherapy regimens
Document type:
Draft definitions
Organization / Institution:
Ministry of Health, New Zealand
Author:
Ministry of Health
Target audience:
Medical oncologists, pharmacists, nurse specialists, other DHB staff
Period of validity:
Not specified
Approval date:
Not specified
Date of last modification:
Not specified
Title:
Table 3: Adverse events necessitating treatment modification and steps taken to manage the adverse events in patients of all oral regimens of drug-resistant tuberculosis
Disease:
Drug-resistant tuberculosis
Regimens:
Longer oral regimen; Shorter oral regimen
Sub-regimens:
BQLCC; BDLCC; BELCC
Assessment time points:
1 month; 3 month; 6 month
Total patients with adverse events:
33
Total patients with Linezolid dose reduction:
13
Adverse events reported:
Peripheral neuropathy; Optic neuritis; Hepatotoxicity; Anemia; Tendinitis; Agitation and anxiety; Thrombocytopenia; Joint pain
Drugs mentioned:
Linezolid; Delamanid; Bedaquiline; Isoniazid; Levofloxacin; Moxifloxacin; Cycloserine; Ethambutol; Pyrazinamide
Dose modifications:
Linezolid reduced to 300 mg; Isoniazid reduced to 600 mg and 300 mg
Treatment modifications:
Drug discontinuation; Drug substitution; Temporary interruption of all drugs; Extension of Bedaquiline
Journal Name:
Asian Hematology Research Journal
Manuscript Number:
Ms_AHRJ_137435
Article Title:
Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria
Article Type:
Peer Review Report
Reviewer:
Ashfaque Hossain
Reviewer Affiliation:
USA
Subject Area:
Hematology; HIV Research; Antiretroviral Therapy
Geographic Focus of Study:
Port Harcourt, Nigeria
Key Topics:
Hematologic abnormalities; Haemostatic parameters; D-Dimer levels; Ethical approval; Informed consent; Reference accuracy
Review Outcome:
Major correction necessary
Language Assessment:
Needs English correction
Reference Assessment:
Not sufficient; inconsistent citation formatting; missing and mismatched references
Ethical Concerns Raised:
Lack of statement on ethical approval; absence of informed consent declaration; no disclosure of competing interests
Document Section:
PART 1 and PART 2 Review Comments
Year:
2008–2022
Country:
Italy
Disease:
Waldenström Macroglobulinaemia
Field:
Hematology / Oncology
Study Type:
Retrospective real-life study
Patient Population:
447 treatment-naive WM patients
Treatment Regimens:
Bendamustine-Rituximab (BR); Dexamethasone-Rituximab-Cyclophosphamide (DRC); Other chemo-immunotherapies (R-chemo)
Primary Endpoint:
Progression-Free Survival (PFS)
Secondary Endpoint:
Overall Survival (OS)
Key Variables:
Relative Dose Intensity (RDI); Bendamustine starting dose; Age; Creatinine Clearance
Follow-up:
Long-term follow-up
Statistical Analysis:
Comparative survival analysis with significance testing
Country:
Nigeria
City / Region:
Port Harcourt, Rivers State
Research Location:
Rivers State University Teaching Hospital (RSUTH); University of Port Harcourt Teaching Hospital (UPTH)
Subject Area:
Hematology; Hemostasis; HIV/AIDS Research
Type of Document:
Scientific Research Article
Study Population:
Human Immunodeficiency Virus-Positive subjects aged 20–79 years
Sample Size:
150 participants
Study Groups:
First-line regimen (Abacavir Lamivudine Dolutegravir); Second-line regimen (Tenofovir Lamivudine Dolutegravir); Naïve HIV-positive control group
Medical Conditions Studied:
Human Immunodeficiency Virus (HIV); hematologic abnormalities; haemostatic abnormalities
Laboratory Methods:
Sysmex XP-300 Automated Haematology Analyzer; Enzyme Linked Immunosorbent Assay (ELISA); Prothrombin Time (PT); Activated Partial Thromboplastin Time (APTT)
Statistical Analysis:
Student’s independent t-test; Analysis of Variance (ANOVA); Microsoft Office Excel 2007; GraphPad Prism 6.2
Measured Parameters:
White blood cell count; lymphocyte count; haemoglobin; neutrophil-to-lymphocyte ratio; prothrombin time; activated partial thromboplastin time; D-dimer levels
Study Objective:
Assessment of hematologic and haemostatic profiles in HIV-positive subjects receiving different antiretroviral regimens
Keywords:
Hematologic; Haemostatic; Human Immunodeficiency Virus-Positive Subjects; Antiretroviral regimen; First-line; Second-line; Naïve
Year:
2023
Region / city:
Port Harcourt, Nigeria
Topic:
HIV, Antiretroviral Therapy, Hematologic and Haemostatic Abnormalities
Document Type:
Research Study
Institution:
Rivers State University Teaching Hospital, University of Port Harcourt Teaching Hospital
Author:
Not specified
Target Audience:
Researchers, Healthcare Professionals
Period of Action:
2023
Date of Approval:
Not specified
Date of Changes:
Not specified
Year:
2026
Region / City:
Not specified
Subject:
Pediatric liver transplantation and immune suppression
Document Type:
Clinical study supplement
Institution:
Not specified
Patient Groups:
Cholestatic liver disease (CLD), Acute liver failure (ALF), SLD group
Treatment Details:
Calcineurin inhibitors, Prednisolone, Azathioprine, Tacrolimus, MMF, Basiliximab
Follow-up Period:
Up to 5 years post-transplant
Outcomes:
Re-grafting due to chronic rejection, mortality related to non-adherence
Year:
2023
Region / City:
Soshanguve
Topic:
Tender Procedure for Construction of Pavement at NHBRC Eric Molobi Offices
Document Type:
Tender Invitation
Organ / Institution:
National Home Builders’ Registration Council (NHBRC)
Author:
Not specified
Target Audience:
Contractors registered with CIDB
Period of Validity:
June 2023
Approval Date:
09 June 2023
Date of Amendments:
Not specified
Closing Date:
23 June 2023
Closing Time:
11:00 AM
Year:
2022
Region / city:
Glasgow, United Kingdom
Topic:
Gynaecological oncology, surgery
Document type:
Research article
Organization / institution:
Glasgow Royal Infirmary
Author:
Mr. Chia Yew Kong, Mr. Norman Galbraith, Mr. John Telfer, Prof Steven Lo, Mr. Neil Fairbairn, Mr. Michael Palmer, Mr. Seamus Teahan, Dr. Rhona Lindsay, Dr. Kevin Burton, Professor Campbell Roxburgh, Mr. Peter Chong, Mr. Colin Steele, Dr. Aiste McCormick, Miss Martha Quinn
Target audience:
Medical professionals, researchers in oncology
Period of action:
2018-2022
Approval date:
Not specified
Modification date:
Not specified
Document Number:
7272
Title:
Reading Guide (Organ Systems Part 2)
Subject:
Biology
Topic:
Human Organ Systems
Systems Covered:
Muscular System; Integumentary System; Nervous System; Circulatory System
Type of Document:
Educational worksheet
Intended Audience:
Students
Educational Level:
Secondary education
Content Format:
Fill-in-the-blank questions; Short answer questions; Diagram labeling tasks
Year:
2025-2026
Region / City:
Swansea Bay
Theme:
Organ Donation
Document Type:
Report
Organization / Institution:
NHS Blood and Transplant
Author:
Liz Wonnacott, Head of Service – Medical Director
Target Audience:
Quality and Safety Committee, Health Board Members, Organ Donation Committee
Period of Activity:
2025-2026
Approval Date:
February 2026
Date of Revisions:
December 2025
Context:
Report detailing organ donation activity in Swansea Bay, with updates on donor statistics, committee activities, and planning for Organ Donation Week 2026.
Title:
Activity 4.3.1 Student Resource Sheet
Subject:
Organ transplantation ethics
Topic:
Kidney transplant allocation scenarios
Document Type:
Educational resource sheet
Intended Audience:
Students
Number of Scenarios:
Thirteen
Medical Focus:
Kidney transplantation
Key Themes:
Allocation criteria, medical urgency, waiting time, age, social factors, financial status
Organizations Mentioned:
Organ procurement organization (OPO)
Health Conditions Referenced:
HIV, type 1 diabetes, acute lymphocytic leukemia (ALL), schizophrenia, ovarian cancer
Geographic Scope:
Not specified
Publication Date:
Not specified
Year:
2026
Region / City:
United States
Topic:
Organ procurement and transplantation
Document Type:
Membership application
Organization / Institution:
Organ Procurement and Transplantation Network (OPTN)
Author:
Applicant organization representative
Target Audience:
Organ Procurement Organizations (OPOs)
Effective Period:
Upon submission and approval
Submission Date:
2026-02-28
Required Attachments:
QAPI plan, resumes of administrative and medical directors, agreements with hospitals and laboratories
Legal Compliance:
Adherence to Code of Federal Regulations and OPTN obligations
Insurance Coverage:
Minimum professional liability of $1,000,000
Document Title:
Organ Procurement Facility Emergency Operations Plan
License Year:
Covered license year (not specified)
Type of Document:
Emergency operations plan
Subject:
Emergency preparedness and response for organ procurement organization
Applicable Regulation:
Centers for Medicare and Medicaid Services 486.360
Responsible Authority:
Mississippi State Department of Health, Office of Emergency Planning and Response
Facility Type:
Organ Procurement Organization (OPO)
Scope:
Facility-based and community-based all-hazards emergency preparedness
Key Components:
Risk assessment, incident management, evacuation, recovery, resource management, continuity of operations
Approval:
Signature page with designated officials and regional planners
Review Cycle:
Reviewed and updated at least annually
Attachments and Annexes:
Training plan, mutual aid agreements, communications plan, safety and security, continuity of operations, incident-specific appendices
Year:
2021
Region / City:
Dublin
Topic:
Organ donation and transplantation
Document type:
Job specification
Organization:
Organ Donation Transplant Ireland (ODTI)
Author:
N/A
Target audience:
Healthcare professionals, job seekers in the healthcare sector
Period of validity:
Until position is filled
Approval date:
N/A
Date of changes:
N/A
Year:
2017
Region / city:
Wellington, New Zealand
Theme:
Organ donation and transplantation
Document type:
National strategy report
Organization:
Ministry of Health
Author:
Hon Dr Jonathan Coleman
Target audience:
General public, healthcare professionals, policymakers
Period of validity:
Not specified
Approval date:
June 2017
Amendment date:
Not specified
ISBN:
978-1-98-850267-0 (print), 978-1-98-850268-7 (online)
License:
Creative Commons Attribution 4.0 International
Intended outcome:
Increase deceased organ donation
Context:
Public consultation and sector collaboration
Year:
2022
Region / City:
Chapel Hill, North Carolina
Topic:
Microbial Ecology
Document Type:
Thesis
Organization / Institution:
University of North Carolina at Chapel Hill, Biology Department
Author:
Priya Kosana
Target Audience:
Academic, researchers in microbiology and gastrointestinal studies
Period of Action:
Not specified
Approval Date:
25 March 2022
Date of Changes:
Not specified
Year:
Not specified
Country:
United States
Thematic Focus:
Organ transplantation policy and ethics
Document Type:
Classroom activity and instructional assignment
Governing Framework:
National Organ Transplant Act (1984)
Responsible Organizations:
Organ Procurement and Transplantation Network (OPTN); United Network for Organ Sharing (UNOS)
Setting:
County Hospital Transplant Review Board (simulated scenario)
Target Audience:
Students
Required Materials:
Computer with Internet access; presentation software; Student Resource Sheet; laboratory journal
Subject Matter:
Organ allocation criteria and decision-making process
Legal Context:
Federal regulations prohibiting organ sales and excluding social criteria from allocation decisions
Year:
2004
Region / City:
Nationwide
Topic:
Healthcare, Solid Organ Transplantation
Document Type:
Service Specification
Organization:
Ministry of Health
Author:
Not specified
Target Audience:
Healthcare professionals and service providers
Period of Validity:
Until next review within five years
Approval Date:
April 2004
Amendments Date:
9 April 2014, June 2020
Year:
2026
Type of Document:
Educational Template
Topic:
Organ Donation
Audience:
Students or Public Speaking Participants
Purpose:
To persuade the audience on organ donation
Author:
Not specified
Format:
Outline with Introduction, Body, and Conclusion
Citations:
Works Cited section included