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Scientific research article reporting comparative laboratory analysis of hematologic and haemostatic parameters among HIV-positive individuals receiving two antiretroviral therapy regimens and untreated subjects in Port Harcourt, Nigeria.
Country: Nigeria
City / Region: Port Harcourt, Rivers State
Research Location: Rivers State University Teaching Hospital (RSUTH); University of Port Harcourt Teaching Hospital (UPTH)
Subject Area: Hematology; Hemostasis; HIV/AIDS Research
Type of Document: Scientific Research Article
Study Population: Human Immunodeficiency Virus-Positive subjects aged 20–79 years
Sample Size: 150 participants
Study Groups: First-line regimen (Abacavir Lamivudine Dolutegravir); Second-line regimen (Tenofovir Lamivudine Dolutegravir); Naïve HIV-positive control group
Medical Conditions Studied: Human Immunodeficiency Virus (HIV); hematologic abnormalities; haemostatic abnormalities
Laboratory Methods: Sysmex XP-300 Automated Haematology Analyzer; Enzyme Linked Immunosorbent Assay (ELISA); Prothrombin Time (PT); Activated Partial Thromboplastin Time (APTT)
Statistical Analysis: Student’s independent t-test; Analysis of Variance (ANOVA); Microsoft Office Excel 2007; GraphPad Prism 6.2
Measured Parameters: White blood cell count; lymphocyte count; haemoglobin; neutrophil-to-lymphocyte ratio; prothrombin time; activated partial thromboplastin time; D-dimer levels
Study Objective: Assessment of hematologic and haemostatic profiles in HIV-positive subjects receiving different antiretroviral regimens
Keywords: Hematologic; Haemostatic; Human Immunodeficiency Virus-Positive Subjects; Antiretroviral regimen; First-line; Second-line; Naïve
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Why Won’t It Clot? – Haemostatic Disorders in Dogs
Year: 2023
Region / City: Newmarket, Suffolk, United Kingdom
Topic: Haemostatic Disorders in Dogs
Document Type: Webinar
Organization / Institution: Animal Health Trust
Author: James Warland
Target Audience: Veterinarians and Veterinary Students
Period of Action: Not specified
Date of Approval: Not specified
Date of Changes: Not specified
Context Description: Overview of the most common causes of haemostatic disorders in dogs, discussing clinical signs, diagnosis, and treatment approaches.
Peer Review Comments on “Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria”
Journal Name: Asian Hematology Research Journal
Manuscript Number: Ms_AHRJ_137435
Article Title: Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria
Article Type: Peer Review Report
Reviewer: Ashfaque Hossain
Reviewer Affiliation: USA
Subject Area: Hematology; HIV Research; Antiretroviral Therapy
Geographic Focus of Study: Port Harcourt, Nigeria
Key Topics: Hematologic abnormalities; Haemostatic parameters; D-Dimer levels; Ethical approval; Informed consent; Reference accuracy
Review Outcome: Major correction necessary
Language Assessment: Needs English correction
Reference Assessment: Not sufficient; inconsistent citation formatting; missing and mismatched references
Ethical Concerns Raised: Lack of statement on ethical approval; absence of informed consent declaration; no disclosure of competing interests
Document Section: PART 1 and PART 2 Review Comments
Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria
Year: 2023
Region / city: Port Harcourt, Nigeria
Topic: HIV, Antiretroviral Therapy, Hematologic and Haemostatic Abnormalities
Document Type: Research Study
Institution: Rivers State University Teaching Hospital, University of Port Harcourt Teaching Hospital
Author: Not specified
Target Audience: Researchers, Healthcare Professionals
Period of Action: 2023
Date of Approval: Not specified
Date of Changes: Not specified
Directory for trans* individuals undergoing Hormone Replacement Therapy (HRT) and HIV-positive refugees Access to medical support
Year: 2023
Region / City: Austria
Theme: Healthcare support for trans* individuals and HIV-positive refugees
Document type: Directory
Organization: Multiple healthcare providers
Author: Not specified
Target audience: Trans* individuals undergoing HRT, HIV-positive refugees
Period of validity: Ongoing
Date of approval: Not specified
Date of changes: Not specified
Supplementary Tables 1–5. Percentages of T Cell and Monocyte Phenotypes and Their Associations with Pulmonary Function Measures in HIV-Positive and HIV-Negative Participants
Document type: Supplementary tables
Study population: HIV-positive (n=142) and HIV-negative (n=73) participants
Subgroup analysis: HIV-negative participants (n=71 with pre-; n=73 with post- measurements)
Measured variables: CD4 T cell phenotypes, CD8 T cell phenotypes, monocyte phenotypes
Phenotype categories: Differentiation, Activation Profiles, Inflammation/Exhaustion Profiles, Senescence Profiles
Monocyte subsets: Classical, Intermediate, Non-Classical
Pulmonary function measures: FEV1, FVC, FEV1/FVC, DLCO
Statistical methods: Two-sample t-test; linear regression models with adjustment for HBV infection, HCV infection, smoking pack-years, body-mass index, marijuana use, crack cocaine use, injection drug use, tuberculosis, pneumonia
Data presentation: Median (IQR); standardized beta coefficients
Reference standards: NHANES III predicted lung function values
Significance thresholds: P < 0.05 with Bonferroni correction (P=0.05/112)
Peer Review Comments on “Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria”
Journal Name: Asian Hematology Research Journal
Manuscript Number: Ms_AHRJ_137435
Article Title: Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria
Article Type: Peer Review Report
Reviewer: Ashfaque Hossain
Reviewer Affiliation: USA
Subject Area: Hematology; HIV Research; Antiretroviral Therapy
Geographic Focus of Study: Port Harcourt, Nigeria
Key Topics: Hematologic abnormalities; Haemostatic parameters; D-Dimer levels; Ethical approval; Informed consent; Reference accuracy
Review Outcome: Major correction necessary
Language Assessment: Needs English correction
Reference Assessment: Not sufficient; inconsistent citation formatting; missing and mismatched references
Ethical Concerns Raised: Lack of statement on ethical approval; absence of informed consent declaration; no disclosure of competing interests
Document Section: PART 1 and PART 2 Review Comments
Haematologic and Haemostatic Profiles of Human Immunodeficiency Virus-Positive Subjects on Two Anti-Retroviral Regimens in Port Harcourt, Nigeria
Year: 2023
Region / city: Port Harcourt, Nigeria
Topic: HIV, Antiretroviral Therapy, Hematologic and Haemostatic Abnormalities
Document Type: Research Study
Institution: Rivers State University Teaching Hospital, University of Port Harcourt Teaching Hospital
Author: Not specified
Target Audience: Researchers, Healthcare Professionals
Period of Action: 2023
Date of Approval: Not specified
Date of Changes: Not specified
Topics: Haemostatic HIV-positive Haematologic