№ lp_2_1_12476
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Supplementary scientific table presenting demographic and epidemiological context alongside sex, age, tumor type, and geographic distribution of participants enrolled in a multi-country study of HER2-positive solid tumors.
Document type:
Supplementary table
Study focus:
Representativeness of participants with HER2-positive solid tumors
Cancer type:
HER2-Positive Solid Tumors
Countries involved:
Spain, United Kingdom, Germany
Sample size:
18 participants
Sex distribution:
4 male (22 %), 14 female (78 %)
Median age:
63 years
Age range:
46–77 years
Tumor types represented:
Breast cancer, Uterus cancer, Stomach cancer, Colorectal cancer, Paget’s disease extramammary, Gastroesophageal cancer
HER2 positivity definition:
IHC 3+
Geographical scope of epidemiological context:
Worldwide, United States, Europe
Data sources cited:
Global Cancer Observatory; SEER Program; National Cancer Institute; Eurostat; National Center for Health Statistics; JAMA Oncology
Access date of cited online sources:
3rd September 2025
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2022
Region / city:
Brno
Topic:
Cancer research, cell culture, immunotherapy
Document type:
Research article
Institution:
University Hospital Brno
Author:
Not specified
Target audience:
Researchers, medical professionals
Period of validity:
Not specified
Approval date:
2022/1680/MOU
Date of amendments:
Not specified
Year:
2022
Region / City:
Bethesda, Maryland, USA; Atlanta, Georgia, USA
Subject:
Genetic Ancestry, Cohort Study, Genome-wide Association Study (GWAS)
Document Type:
Research Article
Organization / Institution:
National Institutes of Health, Georgia Institute of Technology, National Library of Medicine
Author:
Manoj S. Kambara, Shivam Sharma, John L. Spouge, I. King Jordan, Leonardo Mariño-Ramírez
Target Audience:
Researchers in genomics, public health, and related fields
Period of Action:
2018-2022
Approval Date:
7/1/2022
Date of Changes:
Not specified
Year:
2021
Region / City:
United States
Topic:
Glioma Studies, Cancer Epidemiology
Document Type:
Supplementary Table
Organization / Institution:
Not specified
Author:
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D
Target Audience:
Researchers, Oncologists
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Version:
1.5.0.0
Protocol Posting Date:
June 2024
CAP Laboratory Accreditation Program Protocol Required Use Date:
March 2025
Authors:
Gulisa Turashvili, MD, PhD; Uma G. Krishnamurti, MD, PhD; Barbara A. Crothers, DO; Giovanna A. Giannico, MD; Krisztina Hanley, MD; Anna Plotkin, MD; Anthony N. Karnezis, MD, PhD.
Note:
Accreditation Requirements
Date of Protocol Posting:
June 2024
Date of Required Use:
March 2025
Version:
4.2.0.0
Protocol Posting Date:
June 2024
Year:
2024
Region / city:
Not specified
Topic:
Bone tumor biopsy protocols
Document type:
Protocol
Organization / institution:
Not specified
Author:
Paari Murugan, MD, FCAP; Julie C. Fanburg-Smith, MD, FCAP; Andrew Horvai, MD, PhD; Fernanda Amary, MD, PhD; Meera Hameed, MD, FCAP; Michael J. Klein, MD
Target audience:
Clinicians and pathologists involved in biopsy procedures for bone tumors
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Version:
5.0.0.0
Protocol Posting Date:
December 2023
CAP Laboratory Accreditation Program Protocol Required Use Date:
September 2024
Authors:
Dhanpat Jain, MD; William V. Chopp, MD; Rondell P. Graham, MBBS
Accreditation Requirements:
Core data elements required for clinical care and accreditation purposes. Optional data elements for reporting as determined by local standards.
Procedure:
Resection, biopsy, excision biopsy
Tumor Type:
Well-differentiated neuroendocrine tumor
Year:
2017
Region / City:
N/A
Topic:
Retinoblastoma, Germ Cell Tumors, Hepatoblastoma
Document Type:
Medical Case Study
Organization / Institution:
N/A
Author:
Carlos Rodriguez-Galindo, MDA
Target Audience:
Medical Professionals
Period of Action:
N/A
Approval Date:
N/A
Modification Date:
N/A
Year:
2024
Region / City:
N/A
Topic:
Medical protocol
Document Type:
Protocol
Organization / Institution:
CAP Laboratory Accreditation Program
Authors:
Julie C. Fanburg-Smith, MD, FCAP; Paari Murugan, MD, FCAP; Andrew Horvai, MD, PhD; Fernanda Amary, MD, PhD; Meera Hameed, MD, FCAP; Michael J. Klein, MD.
Target Audience:
Pathologists, medical professionals in oncology
Effective Period:
March 2025
Approval Date:
June 2024
Date of Changes:
June 2024
Year:
2023
Region / city:
Wuhan, China
Topic:
Medical Imaging, Artificial Intelligence, Gastrointestinal Stromal Tumors
Document Type:
Research Article
Organization / Institution:
Renmin Hospital of Wuhan University
Authors:
Chenxia Zhang, Wei Tan, Xun Li, Xiao Tao, Bing Xiao, Wei Zhou, Honggang Yu
Target Audience:
Medical professionals, researchers in gastroenterology and artificial intelligence
Period of Application:
Not specified
Date of Approval:
Not specified
Date of Changes:
Not specified
Keywords:
Gastrointestinal Stromal Tumors, Endoscopic Ultrasound, Artificial Intelligence, Risk Stratification, Deep Learning
Methodology:
Image Classification, Image Segmentation, Deep Convolutional Neural Network (DCNN), ResNet, Unet++
Evaluation Metrics:
Accuracy, Intersection over Union (IoU), Precision, Recall, F1 score
Conclusion:
The use of AI-based risk stratification and image analysis improves GIST diagnosis accuracy
References:
Li J, Zhu Y, Dong Z, et al., Yao L, Zhang J, Liu J, et al., Zhou Z, Siddiquee MMR, Tajbakhsh N, Liang J
Document type:
Supplementary tables and figures
Subject:
Proton therapy and VMAT treatment planning and dosimetric analysis
Techniques evaluated:
IMPT, VMAT
Clinical indications:
Base of skull tumors, paediatric craniopharyngioma, chordoma, chondrosarcoma
Structures analyzed:
Brain, Brainstem, Optic chiasm, Optic nerves, CTV
Dose metrics:
Mean dose, Maximum dose, EQD2, BED, LETd
Robustness parameters:
Isocenter shifts ±3.0 mm; Proton range uncertainty ±3.5%
Fractionation scheme:
1.67 Gy(RBE) fractions
Constraint source:
EPTN dose constraints
Number of patients:
6 adult cases
Comparative models:
Nominal IMPT, Worst case IMPT uncertainty, VMAT, McNamara variable RBE model (α/β)x = 2–4 Gy
Figures included:
Beam arrangement views, dose distributions, LETd maps, DVHs, robustness analysis
Year:
2026
Region / City:
International / Multiple research institutions
Subject:
Cancer immunotherapy, tumor microenvironment
Document type:
Supplementary scientific data
Institution:
University of Southampton, Genkyotex SA, La Jolla Institute for Allergy & Immunology, University of Toronto, University of Kent
Authors:
Kirsty Ford, Christopher J. Hanley, Massimiliano Mellone, Cedric Szyndralewiez, Freddy Heitz, Philippe Wiesel, Oliver Wood, Maria Machado, Monette Lopez, Anusha-Preethi Ganesan, Chuan Wang, Ankur Chakravarthy, Tim Fenton, Emma V. King, Pandurangan Vijayanand, Christian H. Ottensmeier, Aymen Al-Shamkhani, Natalia Savelyeva, Gareth J. Thomas
Target audience:
Researchers in oncology and immunology
Data type:
Figures, tables, and experimental results
Methods:
Q-PCR, immunofluorescence, IHC, RNA sequencing, gene network analysis
Experimental models:
Murine syngeneic tumors, TC1, MC38, 4T1, BALBneuT breast tumors
Treatment tested:
NOX4 inhibition, TGF-β1 inhibition, αPD-1, αCTLA-4, macrophage depletion
Key focus:
CAF-mediated CD8 T-cell exclusion, tumor growth modulation, immunotherapy response
Supplementary content:
Figures S1–S6, Tables S1–S2
Year:
2023
Region / City:
Not specified
Subject:
Pathology, Neuroendocrine Tumors
Document Type:
Clinical Protocol
Organization / Institution:
College of American Pathologists (CAP)
Authors:
Dhanpat Jain, MD; William V. Chopp, MD; Rondell P. Graham, MBBS
Target Audience:
Pathologists, Laboratory Personnel
Effective Period:
September 2024
Protocol Version:
2.0.0.0
Procedures Covered:
Segmental resection, Ileocolic resection
Tumor Types Covered:
Well-differentiated neuroendocrine tumors of the jejunum and ileum
Accreditation Required:
Yes, for primary resection specimens
Exclusions:
Biopsies, recurrent tumors, metastatic tumors, duodenum/ampulla tumors, poorly differentiated NEC, non-GIST sarcomas, lymphomas, GIST
Synoptic Reporting:
Core and conditional data elements required
Histologic Grades:
G1, G2, G3, GX
Data Elements:
Tumor size, focality, mitotic rate, Ki-67 labeling index, pathologic stage, margins
Summary of Changes:
AJCC 9 pTNM staging, WHO 5th Edition updates, lymphovascular invasion updated
Year:
2021
Study type:
Clinical research
Document type:
Supplementary materials
Authors:
Not specified
Institution:
Not specified
Target audience:
Researchers in oncology and virology
Tumor types:
Glioma, Meningioma, Pituitary adenoma, Craniopharyngioma, Ependymoma, Schwannoma, Haemangioblastoma, Chordoma, Brain metastases from breast, lung, kidney, colon cancer
Methods:
Immunohistochemistry, Immunofluorescence, Gene expression analysis, KEGG enrichment, GSEA
Patient information:
Age, Sex, Preexisting conditions, Preoperative treatment, SARS-CoV-2 PCR status
Figures included:
S1–S6
Tables included:
S1
Key markers analyzed:
ACE2, TMPRSS2, CD147, NRP1, IFN-γ, PD-1, FOXP3, CD8, CD4, C1q, C3, IgG, IgM, CD68, TTF1, MUC1
Year:
Not specified
Region / City:
Not specified
Topic:
Tumor analysis, prostate cancer (PC), ISUP classification
Document Type:
Research table
Institution / Organization:
Not specified
Author:
Not specified
Target Audience:
Researchers, medical professionals
Period of Action:
Not specified
Date of Approval:
Not specified
Date of Modifications:
Not specified
Context:
A research table comparing tumor samples of prostate cancer patients classified by ISUP scores and their chemical shift variables.
Year:
2023
Journal:
World Journal of Gastrointestinal Oncology
Manuscript Number:
86810
Type:
Review
Authors:
Guo-Qing Chen, Yi Nan, Shi-Cong Huang, Na Ning, Yu-Hua Du, Dou-Dou Lu, Ya-Ting Yang, Fan-Di Meng, Ling Yuan
Affiliations:
College of Pharmacy, Ningxia Medical College; Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University; Traditional Chinese Medicine College, Ningxia Medical University; School of Clinical Medicine College, Ningxia Medical University
Funding:
Young Scholars of Western China, West Light Foundation of the Chinese Academy of Sciences (No. XAB2019AW13); Ningxia Natural Science Foundation (No. 2022AAC02039)
Corresponding Author:
Ling Yuan, PhD, College of Pharmacy, Ningxia Medical College, Yinchuan, Ningxia Hui Autonomous Region, China
Received:
July 9, 2023
Revised:
September 15, 2023
Accepted:
Not specified
Published Online:
Not specified
Keywords:
Ginger, Medicine and food homology, Gastrointestinal cancer, Molecular mechanism
Scope:
Review of pharmacological effects and clinical potential of ginger on gastrointestinal tumors
Year:
2024
Region / city:
Seattle, WA, United States
Subject:
Medical Imaging, Radiology, Oncology
Document type:
Journal article
Institution:
University of Washington School of Medicine
Author:
Woongsoon John Choi, Peggy Lee, Penelope C Thomas, Tanya J Rath, Monique A Mogensen, Roberta W Dalley, Pattana Wangaryattawanich
Target audience:
Radiologists, Oral Surgeons, Healthcare professionals
Period of validity:
2024
Date of approval:
August 27, 2024
Date of revisions:
August 22, 2024
Date of publication:
August 28, 2024
Year:
2026
Region / City:
Not specified
Topic:
Small Cell Lung Cancer, Gene Expression
Document Type:
Supplementary Figure / Research Data
Institution:
GTEx, Amgen
Methodology:
RNA-Seq, Immunohistochemistry, Flow Cytometry
Sample Size:
28 SCLC tumor samples, 3,789 GTEx normal tissue samples, 518 Amgen normal tissue samples
Markers:
DLL3
Data Visualization:
Log2 FPKM + 0.1, Photomicrographs
Experimental Details:
Secondary antibody controls included
Year:
2019
Region / City:
Maryland
Subject:
Cancer / Tumor Reporting
Document Type:
Instruction Manual
Organization / Institution:
Maryland Department of Health
Author:
Maryland Cancer Registry
Target Audience:
Health professionals, medical practitioners, cancer registrars
Effective Period:
Ongoing
Approval Date:
April 2019
Date of Last Modification:
Not specified