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Supplementary scientific figure legends describing transcriptomic and epigenetic analyses of human gastrointestinal tissues and mouse stomach organoids, focusing on CDX2- and HNF4A-mediated intestinal gene regulation and enhancer dynamics in metaplastic transformation.
Document Type: Supplemental figure legends
Field: Molecular biology
Research Area: Gastrointestinal epithelium and intestinal metaplasia
Subjects: CDX2, HNF4A, SOX2, gastric organoids, Barrett’s esophagus, gastric intestinal metaplasia
Biological Material: Human gastrointestinal tissues and mouse stomach organoids
Methods: Single-cell RNA-seq, bulk RNA-seq, ATAC-seq, CUT&RUN, ChIP-seq, GSEA, enhancer analysis, immunohistochemistry, qRT-PCR
Referenced Studies: Busslinger et al. 2021b; Nowicki-Osuch et al. 2021; Owen et al. 2018; Companioni et al. 2017; Singh et al. 2021; Gao and Kaestner 2010; Wang et al. 2013
Key Topics: Transcriptional profiling, chromatin accessibility, enhancer activity, transcription factor binding, intestinalization of gastric epithelium
Species: Homo sapiens; Mus musculus
Pathological Context: Barrett’s esophagus; gastric intestinal metaplasia
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Supplementary Information TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapy
Year: 2023
Region / City: Not specified
Topic: Mycobacterium tuberculosis, transcriptional regulators, TB therapy
Document type: Research article
Institution: Not specified
Author: Miljan Stupar, Lendl Tan, Edward D. Kerr, Christopher J. De Voss, Brian M. Forde, Benjamin L. Schulz, Nicholas P. West
Target audience: Researchers in microbiology and tuberculosis therapy
Period of action: Not specified
Approval date: Not specified
Date of amendments: Not specified
Methodology: qRT-PCR, PCR screening, CRISPRi, drug susceptibility profiling
Context: A scientific research article detailing the role of the TcrXY transcriptional regulator in Mycobacterium tuberculosis and its potential as a target for improved tuberculosis therapy.
Data Evaluation Record for Estrogen Receptor Transcriptional Activation Assay (HeLa-9903, 2011)
Year: 2011
Study Type: Estrogen Receptor Transcriptional Activation (Human cell Line, HeLa-9903)
Test Material: [chemical name not specified]
CAS Number: [#]
Purity: [#]%
Sponsor: [Name of Study Sponsor]
Laboratory: [lab], location not specified
PC Code: (if applicable)
DP Barcode: (if applicable)
TXR Number: (if applicable)
Cytotoxicity Method: Not specified
Vehicle: Solvent with final concentration [%]
Reference Substances: 17β-estradiol, 17α-estradiol, Corticosterone, 17α-methyltestosterone
Compliance: GLP, Quality Assurance and Data Confidentiality statements [provided/not provided]
Exposure Duration: 23 ±1 hours
Cell Line: hERα-HeLa-9903
Plate Type: 96-well plate
Incubation Conditions: 37°C, 5% CO₂
Replication: Triplicate wells per concentration
Assay System: Steady-Glo® Luciferase Assay System (Promega)
Topics: CDX2 HNF4A transcriptional