№ files_lp_4_process_3_104978
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Methodological supporting appendix presenting mathematical formulations, R functions, Bayesian model structures, and simulation results used to estimate no-effect toxicity concentrations and ECx metrics in ecotoxicological concentration–response analyses.
Field:
Ecotoxicology
Document type:
Supporting information file
Content type:
Methodological appendix with model formulations and simulation data
Subject:
Estimation of no-effect toxicity concentrations (NEC) and ECx metrics
Models described:
NEC3param, NEC4param, ECxLinear, ECxExp, ECxSigmoidal, ECx4param, ECxWeibull1, ECxWeibull2
Software / framework:
jagsNEC (Bayesian modelling approach)
Key parameters:
τ (upper plateau / intercept), η (NEC), β (decay rate), δ (lower plateau), ω (EC50)
Methods included:
Threshold models, sigmoidal decay models, Weibull models
Data type:
Simulated toxicity and concentration–response data
Simulation design:
Multiple sampling schemes with varying treatment levels, replicates, and binomial trials
Measured variable:
Concentration–response relationships for toxicity effects
Chemical context:
Weathered Ichthys condensate WAF expressed as Total Aromatic Hydrocarbons (µg/L TAH)
Biological context:
Tropical marine species responses including A. millepora, S. variolaris, N. dorsatus, and A. amphitrite
Statistical approach:
Bayesian model fitting with MCMC and DIC-based model weighting
Included materials:
R functions for simulation data generation, model equations, simulation study tables, and figure of fitted concentration–response curves
Tables:
Model weight comparison (Table S1); toxicity estimates and effects across simulation designs (Table S2)
Figure:
Concentration–response relationships with Bayesian NEC-sigmoidal model fits (Figure S1)
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2026
Region / City:
Ternopil, Ukraine
Topic:
Environmental science, Toxicology, Biochemistry
Document type:
Research article
Institution:
Ternopil Volodymyr Hnatiuk National Pedagogical University, I. Horbachevsky Ternopil National Medical University, Nature Research Centre
Authors:
Vira Khoma, Viktoria Martinyuk, Tetyana Matskiv, Lesya Gnatyshyna, Vitaliy Baranovsky, Mykola Gladiuk, Brigita Gylytė, Levonas Manusadžianas, Oksana Stoliar
Target audience:
Researchers in environmental science, toxicology, biochemistry
Period of validity:
N/A
Approval date:
N/A
Date of changes:
N/A
Year:
2019
Region / City:
European Union
Topic:
Ecotoxicology, Pesticides
Document Type:
Technical Report
Author:
European Food Safety Authority (EFSA)
Target Audience:
Scientists, Regulatory Bodies, Pesticide Manufacturers
Validity Period:
Not specified
Approval Date:
2019
Amendment Date:
Not specified
Year:
2017
Region / Country:
Netherlands, Portugal, Slovenia
Subject:
Soil ecotoxicology, terrestrial isopods, chemical toxicity
Document type:
Supplementary information
Institution:
Vrije Universiteit Amsterdam; University of Aveiro; University of Ljubljana
Authors:
Cornelis A.M. van Gestel, Susana Loureiro, Primoz Zidar
Target audience:
Environmental scientists, ecotoxicologists
Data type:
Literature review, experimental data summary
Chemicals studied:
Cadmium, zinc, imidacloprid, thiacloprid, dimethoate, abamectin, doramectin, chlorantraniliprole, bisphenol A, vinclozolin, endosulfan, parathion
Isopod species:
Porcellio scaber, Porcellio dilatatus, Porcellionides pruinosus, Armadillidium vulgare
Exposure types:
Soil, food
Endpoints measured:
Survival, reproduction, energy reserves, enzyme activity, protein expression, locomotor function, sublethal effects
Contextual description:
Supplementary data compiling experimental results and literature references on the effects of various chemicals on terrestrial isopods, including toxicity endpoints and exposure conditions.
Year:
2024
Place:
Brussels
Document reference:
Doc. CA/12/2023 rev. 2
Meeting:
52nd Meeting of Competent Authorities for REACH and CLP (CARACAL)
Session:
Open session
Meeting dates:
1–2 July 2024
Meeting format:
Hybrid
Concern:
CLP classification and labelling of formulations containing micro-encapsulated chemicals
Agenda point:
CLP Open session, AP 7
Action requested:
Discussion and comments
Deadline for written comments:
4 September 2024
Issuing bodies:
European Commission Directorate-General for Environment; Directorate-General for Internal Market, Industry, Entrepreneurship and SMEs
Regulatory framework:
CLP Regulation; REACH Regulation
Document status:
Revision 2
Revision history:
Simplification following comments from AT, NL, SE and CropLife Europe
Purpose:
Collection of CARACAL views on classification and labelling approaches
Target group:
Competent authorities under REACH and CLP
Year:
19xx
Note:
Region / City
Subject:
Chemical testing methods for AI formulations
Document Type:
Technical specification
Target Audience:
Technical specialists in chemical analysis and formulation
Year:
Not specified
Region / City:
Taiyuan, Shanxi, China
Theme:
Surfactant properties, metal cleaning
Document Type:
Research article
Organization / Institution:
College of Chemistry and Chemical Engineering, Shanxi Key Laboratory of Chemical Product Engineering, Taiyuan University of Technology
Author:
Jing Huang, Qingwen Dong, Xu Li, Lei Liu, Jinxiang Dong
Target Audience:
Researchers, chemical engineers, surfactant formulators
Effective Period:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2026
Region / city:
Taipei City, Helsinki, Malmö
Topic:
Pharmaceutical formulation, Inhalation therapy
Document type:
Research article
Institution:
HCmed Innovations Co. Ltd., Nanoform Finland Oyj, Inhaled Delivery Consulting AB
Author:
Edgar H. Cuevas Brun, Barry Derham, Yulia Degtyareva, Pablo Luis Gutierrez Carvalho, Gunilla Petersson, Sarah Byrne, Lucy Hardaker, Jesse Heikkilä, Elisabetta Micelotta
Target audience:
Researchers, pharmaceutical professionals, healthcare practitioners
Period of validity:
N/A
Date of approval:
N/A
Date of changes:
N/A
Year:
2026
Region / City:
In-house
Subject:
Cannabinoid Assay in MCT Oil
Document Type:
Method Validation Report
Organization / Institution:
Pharmalytics
Author:
In-house
Target Audience:
Analysts and Supervisors
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2026
Region / City:
Not specified
Subject:
Lipid nanoparticles, gene delivery, T cell transfection
Document type:
Research supplementary material
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers in molecular biology and gene therapy
Experimental system:
Jurkat cells
Analyzed molecules:
DOPE, Cholesterol, C12-200, C14-PEG 2000, CAR-CD19BBz, ZsGreen pDNA
Methods:
Microfluidic mixing, electroporation, Lipofectamine comparison
Measured parameters:
Hydrodynamic diameter, polydispersity index, zeta potential, cell viability, transfection efficiency
Figures included:
S1–S5
Statistical analysis:
One-way ANOVA, unpaired t test
Year:
2026
Region / city:
Not specified
Theme:
Physicochemical properties of liquid soap
Document type:
Research study
Author:
Not specified
Target audience:
Researchers, chemists, professionals in the cosmetics industry
Period of validity:
Not applicable
Approval date:
Not specified
Modification date:
Not specified
Year:
Not specified
Region / Organization:
FAO/WHO
Subject:
Agrochemical formulation standards
Document type:
Technical guideline
Active ingredient:
Defined per ISO common name
Form:
Homogeneous liquid
Storage conditions:
0 ± 2 °C for 7 days, 54 ± 2 °C for 14 days
Viscosity:
As specified in MT 22.1
Impurities:
By-products of manufacture or storage, water content limits
Testing methods:
CIPAC, AOAC or equivalent
Purpose:
Establish parameters for UL formulation stability, identity, and drift potential
Publication reference:
CIPAC number / UL (month & year of publication)