№ lp_2_3_62712
File format: docx Character count: 94032 File size: 455 KB
The document is a scientific research article exploring the genetic control of crossover recombination in Arabidopsis thaliana, focusing on the HEI10 meiotic E3 ligase gene and its role in recombination variability.
Year: 2016
Region / city: Not specified
Topic: Genetics, Plant Biology
Document Type: Research Article
Institution: Not specified
Author: Piotr A. Ziolkowski, Charles J. Underwood, Christophe Lambing, Marina Martinez-Garcia, Emma J. Lawrence, Liliana Ziolkowska, Catherine Griffin, Kyuha Choi, F. Chris H. Franklin, Robert A. Martienssen, Ian R. Henderson
Target Audience: Researchers, Academics
Period of Action: Not specified
Approval Date: Not specified
Modification Date: Not specified
Price: 8 / 10 USD
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The E3 ubiquitin ligase NEDD4L targets OGG1 for ubiquitylation and modulates the cellular DNA damage response
Authors: Jonathan R. Hughes; Jason L. Parsons
Affiliations: Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK; Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, UK
Correspondence: Jason L. Parsons ([email protected]
Note: )
Keywords: DNA damage; DNA repair; OGG1; NEDD4L; ubiquitin
Thematic area: Molecular biology; DNA repair; Cancer research
Main proteins studied: OGG1; NEDD4L
Biological pathway: Base excision repair (BER) pathway
Type of document: Scientific research article
Research focus: Regulation of OGG1 by ubiquitylation and its impact on cellular response to oxidative DNA damage
Experimental context: Human cell extracts; U2OS cells; in vitro ubiquitylation assays; ionising radiation-induced oxidative stress
Findings summary: Identification of NEDD4L as a major E3 ubiquitin ligase for OGG1 and analysis of its effect on OGG1 stability, activity, DNA repair capacity, and cell survival
Abstract included: Yes
Sections included: Abstract; Introduction
Topics: HEI10 meiotic ligase