№ files_lp_3_process_7_062231
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Scientific research article reporting the identification of NEDD4L as an E3 ubiquitin ligase targeting OGG1 and examining its role in regulating base excision repair and cellular responses to oxidative DNA damage.
Authors: Jonathan R. Hughes; Jason L. Parsons
Affiliations: Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK; Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, UK
Correspondence: Jason L. Parsons ([email protected]
Note: )
Keywords: DNA damage; DNA repair; OGG1; NEDD4L; ubiquitin
Thematic area: Molecular biology; DNA repair; Cancer research
Main proteins studied: OGG1; NEDD4L
Biological pathway: Base excision repair (BER) pathway
Type of document: Scientific research article
Research focus: Regulation of OGG1 by ubiquitylation and its impact on cellular response to oxidative DNA damage
Experimental context: Human cell extracts; U2OS cells; in vitro ubiquitylation assays; ionising radiation-induced oxidative stress
Findings summary: Identification of NEDD4L as a major E3 ubiquitin ligase for OGG1 and analysis of its effect on OGG1 stability, activity, DNA repair capacity, and cell survival
Abstract included: Yes
Sections included: Abstract; Introduction
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