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Conference abstract and biographical note presenting a literature-based review of XPO1 inhibition in solid malignant tumors, summarizing preclinical and clinical evidence, mechanisms of action, therapeutic potential, adverse effects, and biomarker research within contemporary oncology studies.
Document type:
Conference abstract and author biography
Presentation type:
Oral presentation
Research field:
Oncology
Topic:
XPO1 inhibition in solid malignant tumors
Author:
Chuanxi Lai
Affiliation:
Zhejiang University, School of Medicine
Academic status:
PhD candidate
Degree:
Bachelor of Medicine (2021)
Country:
China
Contact email:
[email protected]
Phone number:
86-18868117165
Journal mentioned:
Clinical and Translational Medicine
Keywords:
Exportin-1, XPO1, SINE inhibitors, selinexor, eltanexor, solid tumors, clinical trials, drug resistance
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2016
Region / city:
Oxford, Bristol, Nottingham, York
Theme:
Medical, Oncology
Document Type:
Guideline
Organization / institution:
John Radcliffe Hospital, Bristol Children’s Hospital, University of York
Author:
Rebecca Proudfoot, John Radcliffe Hospital, Rachel Cox, Bristol Children’s Hospital, Bob Phillips, University of York, Sophie Wilne, University Hospitals Nottingham NHS Trust
Target audience:
Healthcare professionals involved in pediatric oncology
Period of validity:
Ongoing recommendations
Approval Date:
July 2016
Date of revisions:
Not mentioned
Context:
Clinical guideline for the prevention of Pneumocystis Jirovecii Pneumonia in children with solid tumors undergoing oncological treatments.
Year:
2017
Region / city:
Oxford, UK
Topic:
Cancer staging
Document type:
Classification guide
Organization / institution:
UICC
Author:
Brierley JD, Gospodarowicz MK, Wittekind C
Target audience:
Medical professionals, oncologists
Period of validity:
From 1 January 2018
Date of approval:
2017
Date of changes:
N/A
Year:
2018
Region / City:
Global
Topic:
Cancer Staging
Document Type:
Medical Classification
Organization / Institution:
UICC
Author:
Brierley JD, Gospodarowicz MK, Wittekind C
Target Audience:
Healthcare professionals, oncologists, pathologists
Period of Validity:
Ongoing
Date of Approval:
2017
Date of Changes:
Not specified
Year:
2014
Region / city:
Not specified
Subject:
Mortality following palliative chemotherapy
Document type:
Audit report
Institution:
Not specified
Author:
Rafael Silverman
Target audience:
Clinical departments and healthcare professionals involved in palliative care and chemotherapy
Period of validity:
Not specified
Approval date:
Not specified
Last reviewed:
2 May 2024
Contextual description:
A departmental audit assessing short-term mortality rates following palliative chemotherapy for solid tumours in a specific time period.
Year:
2023
Region / City:
United Kingdom
Topic:
Ovarian Tumours in Children
Document Type:
Survey Report
Organization / Institution:
British Association of Paediatric Surgeons (BAPS), Children’s Cancer and Leukaemia Group (CCLG)
Author:
Not specified
Target Audience:
Paediatric Surgeons, Paediatric Oncology Specialists
Period of Validity:
Not specified
Date of Approval:
Not specified
Date of Changes:
Not specified
Contextual Description:
A national survey report detailing varying approaches among paediatric surgeons in the UK regarding the management of ovarian tumours in prepubertal children, focusing on diagnostic procedures, surgery, and follow-up practices.
Year:
2020
Institution:
AmSECT
Document Type:
Clinical guideline
Target Population:
Patients with previously diagnosed risk or sudden onset of Malignant Hyperthermia
Purpose:
Guidance for detection, diagnosis, and management of Malignant Hyperthermia
Procedures Included:
Perfusion pump considerations, pharmacologic interventions, cooling strategies, laboratory testing
Approval:
Chief Medical Officer, Chief Nursing Executive
Effective Date:
2020
Version Number:
1.0
Review Period:
As changes occur or per institutional protocol
Year:
2006
Region / city:
United Kingdom
Topic:
Dermatology, Skin Cancer Treatment
Document Type:
Medical Treatment Guidelines
Institution:
National Institute for Health and Care Excellence (NICE)
Author:
Not specified
Target Audience:
Healthcare providers, General Practitioners (GPs), Dermatologists
Period of validity:
Not specified
Approval Date:
Not specified
Date of amendments:
Not specified
Year:
2014
Region / City:
Seattle
Topic:
Medical Genetics
Document Type:
Clinical Guidelines
Organization / Institution:
University of Washington
Author:
Schneiderbanger D, Johannsen S, Roewer N, Schuster F
Target Audience:
Healthcare professionals, Anesthesiologists
Period of Validity:
Not specified
Date of Approval:
2014
Date of Changes:
Not specified
Authors:
Joseph Westaby; Nesreen Magdy; Cyril Fisher; Mona El-Bahrawy
Institutions:
Department of Histopathology, Imperial College London, UK; Department of Histopathology, National Cancer Institute, Egypt; Sarcoma Unit, The Royal Marsden Hospital, UK; Faculty of Medicine, Alexandria University, Egypt
Corresponding author:
Dr Mona El-Bahrawy
Journal type:
Medical case report
Field:
Histopathology; Oncology; Gynaecological pathology
Keywords:
Perivascular Epithelioid Cell Neoplasms; PEComas; ovary; malignant; primary
Patient age:
54 years
Diagnosis:
Malignant primary ovarian PEComa
Clinical outcome:
Recurrence and death five months after surgery
Language:
English
Year:
2023
Region / City:
Srungavarapukota, Vizianagaram, Andhra Pradesh, India
Study Design:
Observational diagnostic study
Subjects:
Adult buffaloes aged 5–6 years
Diseases Investigated:
Border Disease Virus, Malignant Catarrhal Fever, Infectious Bovine Rhinotracheitis, Bovine Viral Diarrhea
Methodology:
Clinical evaluation, PCR, ELISA, sequencing, phylogenetic analysis
Results:
Co-infection with OvHV-2 and Border Disease Virus detected
Key Findings:
Sheep acted as primary reservoir, interspecies transmission risk highlighted
Target Audience:
Veterinary researchers and animal health professionals
Sample Collection Period:
November 2023
Laboratory Tests:
PCR for OvHV-2, Pestivirus, and IBR; ELISA for BVD
Type of document:
Clinical guideline and referral form
Medical condition:
Malignant Spinal Cord Compression (MSCC)
Clinical status:
Oncological emergency
Institutions mentioned:
Southampton, Poole, Bath, SUHT
Responsible teams:
Acute Oncology Team (AOT); Clinical Oncology; Neurosurgery; Hospital Palliative Care Team (HPCT)
Required actions:
Urgent MRI spine; SINS score calculation; flat bed rest for SINS >6; dexamethasone administration; urgent referral to cancer centre
Medication specified:
Dexamethasone 16mg initial dose then 8mg b.d.; Lansoprazole 30mg o.d.; analgesia
Transfer requirement:
Urgent transfer for radiotherapy or neurosurgery
Contact method:
Bleep numbers and hospital telephone contacts
Documentation fields:
Referral times; MRI timing; confirmation of MSCC; signatures; transfer time; rehabilitation referral; audit entry
Target audience:
Referring doctors and Acute Oncology Team staff
Year:
2018
Region / City:
Global
Topic:
Cancer Staging
Document Type:
Medical Classification
Organization / Institution:
UICC
Author:
Brierley JD, Gospodarowicz MK, Wittekind C
Target Audience:
Healthcare professionals, oncologists, pathologists
Period of Validity:
Ongoing
Date of Approval:
2017
Date of Changes:
Not specified
Year:
2020
Region / city:
UK
Subject:
Veterinary Medicine, Disease Outbreaks
Document Type:
Research Article
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Veterinary professionals, researchers
Period of validity:
Not applicable
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2026
Region / city:
Lanzhou, China
Field:
Oncology, Gastric Cancer
Document Type:
Research Article
Institution:
Gansu University of Chinese Medicine, Gansu Provincial Hospital
Author:
Xiao Dong, Yan Zhang, Na Liu, Jinrui Geng, Yu Li, Yonghong Li
Target Audience:
Researchers, Oncologists, Medical Professionals
Period of Study:
N/A
Approval Date:
N/A
Modification Date:
N/A
Keywords:
BMP8A, gastric cancer, malignant progression, MMP2, mechanism
Context:
A research article detailing the role of BMP8A in promoting gastric cancer progression via MMP2 regulation.
Year:
2026
Location:
United States
Subject:
Immunology, Monoclonal Antibodies, Mast Cell Biology
Document Type:
Research Supplement / Methods Section
Institution:
Kolltan Pharmaceuticals
Authors:
London et al.
Target Audience:
Scientific researchers in immunology and pharmacology
Experimental Period:
2026
Cell Types:
Human CD34+ progenitor cells, PBMCs, mast cells
Key Techniques:
Flow cytometry, antibody assays, cell differentiation, KIT phosphorylation
Reagents:
KTN0158, KTN0062C, KTN0209, KTN0235, Imatinib, Nilotinib, IL-3, IL-6, SCF, LDL
Year:
2021
Protocol Posting Date:
June 2021
Version:
4.1.0.0
Field:
Pathology
Medical Specialty:
Oncologic Pathology
Topic:
Pathologic evaluation of retroperitoneal lymphadenectomy specimens in testicular tumors
Document Type:
Clinical pathology reporting protocol and case summary template
Procedure:
Lymphadenectomy including retroperitoneal lymphadenectomy
Tumor Types Covered:
Germ cell tumors and sex cord-stromal tumors of the testis
Exclusions:
Radical orchiectomy, paratesticular malignancies, extragonadal germ cell tumors, lymphoma, sarcoma
Standard Referenced:
AJCC-UICC 8th Edition staging system
Organization:
College of American Pathologists
Committees:
CAP Cancer Committee; CAP Pathology Electronic Reporting Committee
Primary Authors:
Satish K. Tickoo; Gladell P. Paner; Ming Zhou
Additional Authors:
Lara R. Harik; Robert Allan; Mahul B. Amin; Sam S. Chang; Peter A. Humphrey; James M. McKiernan; Jason Pettus; Victor E. Reuter; John R. Srigley; Thomas M. Ulbright
Intended Users:
Pathologists reporting lymphadenectomy specimens in patients with testicular tumors
Data Structure:
Core, conditional, and non-core data elements for pathology reporting
Clinical Context:
Assessment of lymph node involvement and metastatic tumor characteristics in testicular cancer
Staging System:
Pathologic N classification (pN) according to AJCC 8th Edition
Organization:
MedWaves, Inc.
Headquarters:
San Diego, California, United States
Medical Field:
Neurosurgery
Topic:
Microwave ablation treatment for recurrent brain tumor
Type of Document:
Medical case report and product information statement
Medical Technology:
MedWaves AveCure® Microwave Ablation System
Location of Clinical Use:
Guadalajara, Mexico
Lead Physician:
Doctor Santana
Institution:
Major hospital in Guadalajara, Mexico
Condition Treated:
Recurrent malignant meningioma
Prior Treatments:
Five microsurgeries and full radiation therapy regimen
Procedure Type:
Microwave ablation used as an adjuvant tool in neuromicrosurgery
Patient Outcome Indicator:
Karnofsky Performance Score 90 at discharge
Imaging Method:
Magnetic resonance imaging (MRI)
Hospital Discharge:
8 days after microwave ablation procedure
Regulatory Status:
FDA 510(K), CE Mark, COFEPRIS registered
Manufacturer:
MedWaves, Inc.
Intended Medical Use:
Percutaneous, laparoscopic, and intraoperative coagulation-ablation of soft tissue
Contraindicated Use:
Cardiac procedures
Contact Information:
[email protected]
Note:
, Mobile 760-807-1000
Website:
www.medwaves.com
Year:
2017–2022
Region / City:
Kota Kinabalu, Sabah, Malaysia
Topic:
Neurology, Stroke, Neurosurgery
Document Type:
Retrospective observational cohort study
Institution:
Two tertiary referral centers
Authors:
Not specified
Target Audience:
Medical professionals, neurosurgeons
Patient Population:
Adult MMCAI patients undergoing decompressive craniectomy
Methodology:
CT imaging analysis, volumetric thalamic assessment, multivariable regression
Outcome Measures:
Mortality, NIHSS, mRS, BI, DRS, FOUR score, postoperative complications, hospital stay
Key Findings:
Ipsilateral thalamic volume reduction >14% associated with increased 90-day mortality and worse functional outcomes
Year:
2024
Region / City:
Not specified
Topic:
Neurofibromatosis type 1, Plexiform neurofibromas, Malignant peripheral nerve sheath tumor
Document Type:
Research article
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, medical professionals
Period of Action:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified