№ files_lp_4_process_1_42034
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Experimental biomedical research article presenting a cross-sectional study measuring circulating endothelial microparticles in women with SLE, correlating particle levels with disease activity and age.
Year: 2013–2016
Region / City: Belo Horizonte, Brazil
Topic: Systemic Lupus Erythematosus, Endothelial Microparticles
Document Type: Research Article
Institution: Federal University of Minas Gerais, Santa Casa Hospital
Authors: Walter B. Cicarini, Karine S. Ferreira, Cristina M.G. Loures, Renato V. Consoli, Cláudia L.S. Neiva, Paulo M. Pádua, Fernanda F.C. Nunes, Luan C.V. Alves, Edna A. Reis, Vicente P.C.P Toledo, Bashir A. Lwaleed, Maria G. Carvalho
Funding: CNPq, CAPES, FAPEMIG
Study Design: Cross-sectional
Participants: 90 women, including healthy volunteers and SLE patients with low and moderate/high disease activity
Methods: Blood collection, ultracentrifugation, flow cytometry
Outcome Measures: Endothelial microparticles levels, correlation with SLEDAI-2K Score and age
Ethical Approval: Research Ethics Committee of the Federal University of Minas Gerais, Reference 01928412.8.0000.5149
Inclusion Criteria: Women aged-matched, SLE diagnosis per ACR criteria 1997
Exclusion Criteria: Other autoimmune diseases, anticoagulant use, pregnancy, immunosuppressive diseases
Treatment: Azathioprine, Prednisone, Hydroxychloroquine
Corresponding Author: Bashir A. Lwaleed, University of Southampton, UK
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Supplementary Table 1: Full Ovid MEDLINE Search Strategy for Cutaneous Lupus Erythematosus and Plant-Derived Interventions
Document Type: Supplementary table
Database: Ovid MEDLINE
Subject: Cutaneous Lupus Erythematosus and plant-derived or antimalarial interventions
Content Type: Search strategy
Medical Subject Headings (MeSH): Lupus Erythematosus, Cutaneous; Plants; Plant Structures; Fungi; Bacteria; Herbal Medicine; Antimalarials; Artemisinins; Chloroquine; Quinidine; Quinine
Keywords Included: botanical terms, herbal medicine, traditional Chinese medicine, Janus kinase inhibitors, antimalarial agents, specific plant genera and compounds
Search Fields: Title and abstract (ti,ab)
Boolean Logic: Combination of controlled vocabulary and keyword terms using AND/OR operators
Purpose: Identification of relevant biomedical literature
Systemic Lupus Erythematosus: From Mouse Models to Human Disease and Treatment, September 2–3, 2010, National Institutes of Health, Bethesda, Maryland
Year: 2010
Location: Bethesda, Maryland, USA
Subject: Systemic Lupus Erythematosus, Autoimmune Disease, Translational Research
Document type: Conference Report
Organizers: National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Allergy and Infectious Diseases, Office of Research on Women’s Health, NIH
Collaborators: Lupus Foundation of America, Inc.
Authors/Speakers: Dr. Betty Diamond, Dr. Timothy Behrens, Dr. Howard Young, Dr. Silvia Bolland, Dr. Juan Rivera, Dr. Joe Craft, Dr. Mary Crow, Dr. David Close, Dr. Virginia Pascual, Dr. Mariana Kaplan
Conference dates: September 2–3, 2010
Topics covered: Interferon and innate responses, autoantibodies, lymphocyte activation, clinical challenges, genetic analysis of lupus, translational research from mouse models to human disease
Target audience: Basic and clinical scientists, researchers in academia, industry, and government
Type of sessions: Lectures, panel discussions, and research presentations
Research focus: Mechanisms of lupus pathogenesis, type I interferon signature, B cell and T cell involvement, translational insights from mouse models, therapeutic development, clinical trials
Summary: Conference proceedings detailing presentations and discussions on systemic lupus erythematosus, including translational studies from mouse models to human disease, mechanisms of immune dysregulation, and emerging therapies.
On the stability of spray freeze-dried microparticles for pulmonary drug delivery
Year: 2026
Region / city: Torino, Italy; Parma, Italy
Subject: Pharmaceutical formulation stability; pulmonary drug delivery
Document type: Research article
Institution: Politecnico di Torino; Chiesi Farmaceutici S.p.A.
Authors: Lorena Pasero, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano
Target audience: Pharmaceutical scientists, formulation researchers
Study period: 2026
Methods: Spray freeze-drying, scanning electron microscopy, X-ray diffraction
Active substances: Salbutamol sulphate, mannitol
Excipients: L-leucine, dextran, polysorbate 80
Storage conditions tested: Room temperature, 5°C, -20°C
Intermediate freezing step: 1 h, 5 h
Key findings: Dextran stabilizes δ-mannitol, prevents recrystallization and morphological changes
Context: Experimental study on the stability and morphological changes of spray freeze-dried mannitol microparticles for inhalation delivery under different storage and formulation conditions
Medical Necessity Denial Appeal – DMEK (Descemet’s Membrane Endothelial Keratoplasty) & Coverage of Donor Corneal Tissue
Year: [Today’s Date]
Region / City: [City, State]
Topic: Medical Appeal, Medicare Reimbursement, Corneal Transplantation
Document Type: Appeal Letter
Organization: [Medicare Contractor Name]
Author: [Physician Name]
Target Audience: Medicare Appeals Analyst
Effective Period: [Date of Surgery]
Approval Date: [Today’s Date]
Modification Date: [Date of Surgery]
Medical Necessity Denial Appeal – DSAEK (Descemet’s Stripping Automated Endothelial Keratoplasty) & Coverage of Donor Corneal Tissue
Year: 2023
Region / City: United States
Topic: Medical Necessity, Insurance Reimbursement
Document Type: Appeal Letter
Organization: [Insurance Provider]
Author: [Physician Name]
Target Audience: Appeals Department, Insurance Provider
Period of Effect: N/A
Approval Date: N/A
Date of Changes: N/A
Topics: Erythematosus Microparticles Endothelial